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免疫与感染

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HIV逆转录酶和整合酶抑制剂的快速筛选

JoVE 杂志
免疫与感染

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JoVE 杂志免疫与感染

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

HIV逆转录酶和整合酶抑制剂的快速筛选

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17,646 Views

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05:46 min

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April 09, 2014

DOI:

10.3791/51400-v

DOI:

10.3791/51400-v

•

05:46 min

April 09, 2014

•

8 Views

Steven J. Smith¹, Stephen H. Hughes¹

¹HIV Drug Resistance Program,National Cancer Institute

Summary

这里我们描述了细胞的细胞毒性和单轮感染性测定允许对化合物的快速，准确的筛选以确定它们的细胞毒性（CC _50）和IC ₅₀值对WT和耐药性的HIV-1。

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