Olfactory Assays for Mouse Models of Neurodegenerative Disease

Andrew M. Lehmkuhl; Emily R. Dirr; Sheila M. Fleming

doi:10.3791/51804

Journal

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神经科学

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嗅觉测定的神经退行性疾病的小鼠模型

JoVE 杂志
神经科学

This content is Free Access.

JoVE 杂志神经科学

Olfactory Assays for Mouse Models of Neurodegenerative Disease

嗅觉测定的神经退行性疾病的小鼠模型

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21,766 Views

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07:27 min

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August 25, 2014

DOI:

10.3791/51804-v

DOI:

10.3791/51804-v

•

07:27 min

August 25, 2014

•

4 Views

Andrew M. Lehmkuhl¹, Emily R. Dirr^2,3, Sheila M. Fleming^1,2

¹Department of Psychology,University of Cincinnati, ²Department of Neurology,University of Cincinnati, ³Department of Neuroscience, Cell Biology, and Physiology,Wright State University

Summary

Impairment in olfactory function is a common feature in many neurodegenerative disorders including Parkinson, Alzheimer, and Huntington diseases. In the present article, we describe a set of tests for assessing olfaction discrimination and detection in mice that can be used to measure olfactory abilities in mouse models of neurodegenerative diseases.