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Protocol for Studying Extinction of Conditioned Fear in Naturally Cycling Female Rats

Article DOI: 10.3791/52202-v • 10:44 min • February 23rd, 2015
February 23rd, 2015 •
1,2, 1, 1, 1,2, 1,2
1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School

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Gonadal hormones such as estrogen modulate memory formation in a number of experimental paradigms including fear extinction memory. This protocol describes a set of methods for investigating the influence of gonadal hormones specifically during extinction in naturally cycling females, including estrous cycle monitoring and exogenous estrogen administration.

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Protocol Studying Extinction Conditioned Fear Naturally Cycling Female Rats Male Rodents Neural Mechanisms Behavioral Tasks Response Behaviors Females Males Research Studies Gonadal Hormones Estrous Cycle Estrogen Fear Extinction Memory Consolidation Vaginal Swabbing Technique Estrous Phase Identification Naturally Cycling Gonadal Hormones Rodent Model
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