High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

Viktoryia Sidarovich; Valentina Adami; Alessandro Quattrone

doi:10.3791/52568

Journal

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生物学

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高通量筛选转录后调控基因的化学调节剂

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High-throughput Screening for Chemical Modulators of Post-transcriptionally Regulated Genes

高通量筛选转录后调控基因的化学调节剂

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9,294 Views

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09:44 min

•

March 03, 2015

DOI:

10.3791/52568-v

DOI:

10.3791/52568-v

•

09:44 min

March 03, 2015

•

5 Views

Viktoryia Sidarovich¹, Valentina Adami², Alessandro Quattrone¹

¹Laboratory of Translational Genomics, Centre for Integrative Biology,University of Trento, ²High Throughput Screening Core Facility, Centre for Integrative Biology,University of Trento

Summary

Here we describe a cell-based reporter gene assay as a valuable tool to screen chemical libraries for compounds modulating post-transcriptional control mechanisms exerted through 3’ UTR.

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High-throughput Screening Chemical Modulators Post-transcriptional Regulation Gene Expression 3′ Untranslated Region Luciferase Reporter Cell-based Assay Primary Screening Counter-screening Post-transcriptional Mechanisms

高通量筛选转录后调控基因的化学调节剂

Summary

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