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Bioengineering
静电纳米纤维支架与渐变的纤维组织
静电纳米纤维支架与渐变的纤维组织
JoVE Journal
Bioengineering
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JoVE Journal Bioengineering
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

静电纳米纤维支架与渐变的纤维组织

Full Text
10,383 Views
09:32 min
April 19, 2015

DOI: 10.3791/52626-v

Karl Khandalavala1, Jiang Jiang1, Franklin D. Shuler2, Jingwei Xie1

1Department of Pharmaceutical Sciences, Mary & Dick Holland Regenerative Medicine Program,University of Nebraska Medical Center, 2Department of Orthopedic Surgery, Joan C. Edwards School of Medicine,Marshall University

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Please note that some of the translations on this page are AI generated. Click here for the English version.

在这里,我们提出了一个协议,以制造静电纳米纤维支架与纤维的顺层组织,并探索在调节细胞形态/定位他们的应用程序。梯度对于纳米纤维支架的物理和化学性质提供了各种各样的在生物医学领域的应用程序。

这种制造技术允许生产纤维组织呈梯度的纳米纤维支架。分级组织在生物医学领域提供了纳米纤维支架的更多用途。静电纺丝能够生产具有大表面积的纳米级纤维支架。

通过将聚合物与挥发性溶剂混合,然后以恒定速率将溶液移动通过施加高压的注射器,使溶液带电,并在聚合物从针尖释放时伸长聚合物。其结果是干燥的纳米级聚合物纤维,可以通过多种方式收集用于各种应用。在该协议中,我们将聚己内酯聚合物纺丝到间隙收集器上,以形成盟友对齐的纤维基材。

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