Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

Karolina Chwalek; Disha Sood; William L. Cantley; James D. White; Min Tang-Schomer; David L. Kaplan

doi:10.3791/52970

Journal

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生物工程

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极化神经组织工程三维蚕丝胶原蛋白为基础的模式

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

JoVE 杂志
生物工程

This content is Free Access.

JoVE 杂志生物工程

Engineered 3D Silk-collagen-based Model of Polarized Neural Tissue

极化神经组织工程三维蚕丝胶原蛋白为基础的模式

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12,431 Views

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06:17 min

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October 23, 2015

DOI:

10.3791/52970-v

DOI:

10.3791/52970-v

•

06:17 min

October 23, 2015

•

3 Views

Karolina Chwalek¹, Disha Sood¹, William L. Cantley¹, James D. White¹, Min Tang-Schomer², David L. Kaplan¹

¹Department of Biomedical Engineering,Tufts University, ²Department of Pediatrics,University of Connecticut Health Center & Connecticut Children’s Medical Center

Summary

Insight into the complex actions of the brain requires advanced research tools. Here we demonstrate a novel silk-collagen-based 3D engineered model of neural tissue resembling brain-like architecture. The model can be used to study neuronal network assembly, axonal guidance, cell-cell interactions and electrical activity.