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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

Article DOI: 10.3791/53047-v • 07:32 min • August 28th, 2015
August 28th, 2015 •
1, 2, 2, 2, 2
1School of Pharmacy, Pacific University, 2Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University

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The goal of this protocol is to describe the preparation and characterization of physically entrapped, poorly water soluble drugs in micellar drug delivery systems composed of amphiphilic block copolymers.

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Individual Drug Loaded Polymeric Micelles Multi-drug Loaded Polymeric Micelles Physically Entrapped Polymeric Micelles Amphiphilic Block Copolymers PEG-b-PLA Micelle Structure Drug Loading Capabilities In Vitro Studies In Vivo Studies Solvent Casting Aqueous Solubility Drug Stability Dynamic Light Scattering Micelle Size Molecular Weight Of Polymer Drug Release Sink Conditions
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