Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

Go Oshima; Melinda E. Stack; Sean C. Wightman; Darren Bryan; Elizabeth Poli; Lai Xue; Kinga B. Skowron; Abhineet Uppal; Sean P. Pitroda; Xiaona Huang; Mitchell C. Posner; Samuel Hellman; Ralph R. Weichselbaum; Nikolai N. Khodarev

doi:10.3791/54657

Journal

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癌症研究

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肝大肠癌转移的高级动物模型:成像技术和转移性克隆性质

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

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癌症研究

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JoVE 杂志癌症研究

Advanced Animal Model of Colorectal Metastasis in Liver: Imaging Techniques and Properties of Metastatic Clones

肝大肠癌转移的高级动物模型:成像技术和转移性克隆性质

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12,600 Views

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11:43 min

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November 30, 2016

DOI:

10.3791/54657-v

DOI:

10.3791/54657-v

•

11:43 min

November 30, 2016

•

12586 Views

Go Oshima*^1,2, Melinda E. Stack*¹, Sean C. Wightman¹, Darren Bryan¹, Elizabeth Poli¹, Lai Xue¹, Kinga B. Skowron¹, Abhineet Uppal¹, Sean P. Pitroda², Xiaona Huang², Mitchell C. Posner¹, Samuel Hellman², Ralph R. Weichselbaum², Nikolai N. Khodarev²

¹Department of Surgery,The University of Chicago ²Department of Radiation and Cellular Oncology and Ludwig Center for Metastasis Research,The University of Chicago

Summary

The ability of metastatic clones to colonize distant sites depends on their proliferation capacity and/or their ability to survive in the host microenvironment without significant proliferation. Here, we present an animal model that allows quantitative visualization of both types of liver colonization by metastatic clones.