A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

Hui-Chun Ku; Shih-Yi Lee; Yuan-Kun Aden Wu; Kai-Chien Yang; Ming-Jai Su

doi:10.3791/54818

JoVE Journal
Medicine

A subscription to JoVE is required to view this content. Sign in or start your free trial.

JoVE Journal Medicine

A Model of Cardiac Remodeling Through Constriction of the Abdominal Aorta in Rats

心脏重构通过大鼠腹主动脉缩窄的模型

Full Text

10,688 Views

07:31 min

December 2, 2016

DOI: 10.3791/54818-v

Hui-Chun Ku¹, Shih-Yi Lee^2,3, Yuan-Kun Aden Wu⁴, Kai-Chien Yang^1,5, Ming-Jai Su¹

¹Graduate Institute of Pharmacology, College of Medicine,National Taiwan University, ²Division of Pulmonary and Critical Care Medicine,Mackay Memorial Hospital, ³Mackay Medicine,Nursing and Management College, ⁴School of Medicine,National Taiwan University, ⁵Department of Internal Medicine,National Taiwan University Hosptial

Please note that some of the translations on this page are AI generated. Click here for the English version.

描述了诱导心脏肥大和重塑的腹主动脉缩窄大鼠模型。一种高效、高度可重复和微创的方法被用于为心肌肥大和功能障碍的研究提供一个简单而有用的平台。

外科手术的总体目标是为研究心肌肥大、重塑和功能障碍提供一个简单的平台。这种方法可以帮助回答心血管领域的关键问题，例如涉及心脏肥大和重塑的信号传导。以及在高血压心脏病中发现新的治疗靶点。

该技术的主要优点是它是一种微创方法，需要非常简单的手术技术，但结果具有高度可重复性。这些技术的影响延伸到我们对高血压心脏病的治疗。由于腹主动脉收缩会引起压力超负荷，最终导致心脏肥大、重塑和心力衰竭。

View the full transcript and gain access to thousands of scientific videos

Explore More Videos

医药第118 高血压性心脏疾病心脏重塑动物模型腹主动脉缩窄纤维化