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Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats
JoVE 杂志
医学
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JoVE 杂志 医学
Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

Transient Middle Cerebral Artery Occlusion Model of Neonatal Stroke in P10 Rats

DOI:
10.3791/54830-v

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07:56 min

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April 21, 2017

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,
1Department of Pediatrics,University of California, San Francisco

Chapters

  • 00:05Title
  • 01:03Middle Cerebral Artery Occlusion
  • 05:15Reperfusion
  • 06:54Results: Unilateral Injury Involving the Striatum and Cortex at 4 Weeks Post-tMCAO
  • 07:27Conclusion

Summary

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Neonatal stroke is a significant cause of early brain injury requiring a translational model with consistent focal injury patterns and high reproducibility in order to enable study. This study describes the detailed surgical procedure for creating a non-hemorrhagic, unilateral focal ischemia-reperfusion injury in full-term-equivalent rodents.

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Transient Middle Cerebral Artery OcclusionNeonatal StrokeP10 RatsIschemic Brain InjuryFocal Arterial Ischemic StrokeReperfusionCommon Carotid ArteryInternal Carotid ArteryExternal Carotid ArterySuture ThreadMicrosurgical Technique

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