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Immunology and Infection

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JoVE Journal Immunology and Infection
Un modèle de souris transmissible transitoirement IL-8 pour le
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Un modèle de souris transmissible transitoirement IL-8 pour le

Article DOI: 10.3791/55499-v • 08:16 min • July 7th, 2017
July 7th, 2017 •
*1, *2, *3, 3, 4, 5,2, 6, 7, 2, 8, 1
1Department of Medicine, General Pathology Division, Cystic Fibrosis Translational Research Laboratory "D. Lissandrini", University of Verona, 2Corporate Preclinical R&D, Chiesi Farmaceutici S.p.A., 3Department of Diagnostic and Public Health, Microbiology Division, University of Verona, 4Dipartimento di Scienze Medico-Veterinarie, University of Parma, 5Department of Biomedical Biotechnological and Translational Sciences, University of Parma, 6Department of Computer Science, University of Verona, 7Department of Neurological, Biomedical and Movement Sciences, University of Verona, 8Cystic Fibrosis Regional Center (CFC), AOUI Verona
* These authors contributed equally

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La méthode décrite ici permet la visualisation de l'activation de l'inflammation dépendante du promoteur de l'IL-8 dans les poumons de la souris par une imagerie bioluminescente non invasive (BLI). Le même animal peut être soumis à BLI à plusieurs reprises pendant jusqu'à deux mois à partir du moment de la livraison de la construction de journaliste de luciférase.

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Immunologie Numéro 125 Inflammation administration de gènes, imagerie bioluminescente interleukine-8 poumon
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