Chondrogenic Pellet Formation from Cord Blood-derived Induced Pluripotent Stem Cells

Yoojun Nam; Yeri Alice Rim; Ji Hyeon Ju

doi:10.3791/55988

JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology

Chondrogenic Pellet Formation from Cord Blood-derived Induced Pluripotent Stem Cells

脐带血诱导的多能干细胞的软骨形成颗粒形成

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12:10 min

June 19, 2017

DOI: 10.3791/55988-v

Yoojun Nam¹, Yeri Alice Rim¹, Ji Hyeon Ju²

¹CiSTEM Laboratory, Convergent Research Consortium for Immunologic Disease, Division of Rheumatology, Seoul St. Mary's Hospital, College of Medicine,The Catholic University of Korea, ²Division of Rheumatology, Department of Internal Medicine, Seoul St. Mary's Hospital, Institute of Medical Science, College of Medicine,The Catholic University of Korea

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在这里，我们提出了一种软骨细胞分化从脐带血单核细胞衍生的人诱导多能干细胞的方案。

该程序的总体目标是从脐带血来源的诱导多能干细胞中产生软骨形成沉淀。通过这个方案，我们可以产生相对大量的软骨形成颗粒。生成的软骨形成颗粒可用于研究或疾病建模、药物筛选和医学研究人员，以加深我们对软骨性质的理解。

去年，人类的软骨迟迟没有修复。因此，软骨退化必须通过保守治疗来治疗。人类 iPSC 具有无限的自我更新能力和多效性，已被强调为软骨修复的新替代细胞来源。

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发育生物学第124期诱导多能干细胞脐带血软骨细胞软骨细胞谱系软骨形成细胞团沉淀培养