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JoVE Journal
Chemistry
Nanosponge 可调大小和交联密度
Nanosponge 可调大小和交联密度
JoVE Journal
Chemistry
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JoVE Journal Chemistry
Nanosponge Tunability in Size and Crosslinking Density

Nanosponge 可调大小和交联密度

Full Text
8,096 Views
11:15 min
August 4, 2017

DOI: 10.3791/56073-v

Laken L. Kendrick-Williams1, Eva Harth1

1Chemistry Department,Vanderbilt University

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Please note that some of the translations on this page are AI generated. Click here for the English version.

这篇文章描述一个调优共价交联纳米粒子从线性聚酯含吊坠功能的大小和交联密度的过程。由裁缝合成参数 (聚合物的分子量、 吊坠功能纳入和交联剂等价物),所需的纳米颗粒大小和交联密度可以实现对药物释放的应用。

这种纳米海绵合成技术的总体目标是理解和利用重要的合成参数来设计和控制形态学的尺寸。这种方法将帮助您生产具有精确尺寸和交联密度的纳米颗粒,用于药物递送应用。该技术的主要优点是它可以针对这些颗粒的不同交联密度以及这些颗粒的不同尺寸进行定制,这在使用这些颗粒的许多应用中是一个非常重要的因素。

虽然这种方法可以通过利用定制的羊毛合成参数来深入了解纳米颗粒设计,但它也可以应用于其他聚合物网络,例如水凝胶和微粒。按照文本实验步骤中的详细说明,从配备磁力搅拌棒的 25 ml 圆底烧瓶中去除水分。冷却后,迅速从圆底培养瓶中取出隔垫,并使用刮刀向培养瓶的最底部添加 2.5 毫克三氟甲磺酸锡。

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