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GPC3-targeting 双特异性抗体, GPC3-S-Fab, 具有强大的细胞毒性

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

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癌症研究

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JoVE 杂志癌症研究

A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity

GPC3-targeting 双特异性抗体, GPC3-S-Fab, 具有强大的细胞毒性

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8,526 Views

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11:13 min

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July 12, 2018

DOI:

10.3791/57588-v

DOI:

10.3791/57588-v

•

11:13 min

July 12, 2018

•

3 Views

Yanlan Wang^1,2, Jiayu Liu^1,2, Haitao Pan^1,2, Jieyu Xing^1,2, Xiaoqiong Wu^1,2, Qing Li^1,2, Zhong Wang^1,2

¹School of Pharmaceutical Sciences,Sun Yat-Sen University, ²Center for Cellular & Structural Biology,Sun Yat-Sen University

成績單

Summary

在此, 我们提出了一种在大肠杆菌中产生双特异性抗体 GPC3-S-Fab 的协议.纯化 GPC3-S-Fab 对 GPC3 阳性肝癌细胞具有较强的细胞毒性作用。

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