A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Ping Xue; Zhiqiang Wang; Xiaomin Fu; Junjiang Wang; Gopika Punchhi; Andrew Wolfe; Sheng Wu

doi:10.3791/58379

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Developmental Biology

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JoVE Journal Developmental Biology

A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome

Hyperandrogenic 小鼠模型研究多囊卵巢综合征

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08:20 min

October 2, 2018

DOI: 10.3791/58379-v

Ping Xue¹, Zhiqiang Wang¹, Xiaomin Fu^1,2, Junjiang Wang^1,3, Gopika Punchhi¹, Andrew Wolfe^1,4, Sheng Wu^1,4,5

¹Department of Pediatrics,Johns Hopkins University School of Medicine, ²Department of Health,Beijing Military General Hospital, ³Southern Medical University, ⁴Department of Molecular and Cellular Physiology,Johns Hopkins University School of Medicine, ⁵Department of Gynecology and Obstetrics,Johns Hopkins University School of Medicine

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我们描述了一个瘦的 pcos 样小鼠模型的发展与 dihydrotestosterone 丸研究 pcos 的病理生理学和这些 pcos 样水坝的后代。

这种方法可以帮助回答生殖领域的关键问题。和内分泌学。并适用于多囊卵巢综合征或PCOS和超生激素的研究。

这种技术的优点是，它促进一致，均匀，长期释放激素在昂贵的有效方式。J朱斯治疗这个程序将是平雪，一个技术员，从我的实验室。对于二氢酮或 DHT 颗粒制备，请使用剃刀刀片切割 15 毫米的硅胶管。

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发育生物学 140 期多囊卵巢综合征 Dihydrotestosterone (DHT) 发情周期性雄激素青春期雌性后代