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化学

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药物药代动力学和毒理学评估的肠道/肝脏微生理系统

An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

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化学

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An Intestine/Liver Microphysiological System for Drug Pharmacokinetic and Toxicological Assessment

药物药代动力学和毒理学评估的肠道/肝脏微生理系统

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7,733 Views

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08:59 min

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December 03, 2020

DOI:

10.3791/60184-v

DOI:

10.3791/60184-v

•

08:59 min

December 03, 2020

•

8 Views

Talita Miguel Marin¹, Nathalia de Carvalho Indolfo⁴, Silvana Aparecida Rocco¹, Murilo de Carvalho^1,2, Marilia Meira Dias¹, Graziele Izalina Vasconcelos Bento¹, Leandro Oliveira Bortot¹, Desirée Cigaran Schuck³, Márcio Lorencini³, Eduardo Pagani¹

¹Brazilian Biosciences National Laboratory (LNBio),Brazilian Center for Research in Energy and Materials (CNPEM), ²Brazilian Synchrotron Light Laboratory (LNLS),Brazilian Center for Research in Energy and Materials (CNPEM), ³Grupo Boticário, ⁴Institute of Biology,University of Campinas

Summary

我们向对乙酰氨基酚（APAP）暴露了含有肠道和肝脏器官的微生理系统（MPS）。本文介绍了MPS中器官生产和APAP药代动力学和毒理学属性评估的方法。它还描述了验证结果所需的组织功能分析。

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