Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish

Junjie Chen; Ren&#233; R. Sevag Packard

doi:10.3791/60547

JoVE Journal
Developmental Biology

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JoVE Journal Developmental Biology

Displacement Analysis of Myocardial Mechanical Deformation (DIAMOND) Reveals Segmental Heterogeneity of Cardiac Function in Embryonic Zebrafish

心肌机械变形（DIAMOND）的位移分析揭示了胚胎斑马鱼心脏功能的分段异质性

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09:15 min

February 6, 2020

DOI: 10.3791/60547-v

Junjie Chen¹, René R. Sevag Packard^1,2,3

¹Division of Cardiology, Department of Medicine,David Geffen School of Medicine at University of California, Los Angeles, ²Ronald Reagan UCLA Medical Center, ³Veterans Affairs West Los Angeles Medical Center

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该协议的目的是详细说明一种在生理和病理条件下评估胚胎斑马鱼分段心脏功能的新方法。

钻石是斑马鱼胚胎四维分段心脏功能定量评估的第一个开源方法。我们的方法具有千分尺分辨率，可以量化 3D 空间中的局部心脏力学。目前没有其他方法允许这样做。

钻石解开了多索鲁比辛引起的心脏毒性中新的损伤模式。因此，我们相信，我们的方法可以用作高通量在体内筛查化疗引起的心脏毒性的平台。我们目前正在努力使钻石适应哺乳动物的心脏。

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发育生物学问题 156 心脏功能位移化疗损伤再生斑马鱼