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The 6-hydroxydopamine Rat Model of Parkinson’s Disease
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神经科学
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JoVE 杂志 神经科学
The 6-hydroxydopamine Rat Model of Parkinson’s Disease

The 6-hydroxydopamine Rat Model of Parkinson’s Disease

DOI:
10.3791/62923-v

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08:10 min

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October 27, 2021

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, , , , ,
1Department of Psychology, Faculty of Philosophy, Sciences and Letters of Ribeirão Preto,University of São Paulo

Chapters

  • 00:04Introduction
  • 01:00Training for Stepping and Test
  • 03:18Surgical Procedure
  • 06:06Results: Results of Stepping Test and Histological Analysis
  • 07:30Conclusion

Summary

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The 6-hydroxydopamine (6-OHDA) model has been used for decades to advance the understanding of Parkinson's Disease. In this protocol, we demonstrate how to perform unilateral nigrostriatal lesions in the rat by injecting 6-OHDA in the medial forebrain bundle, assess motor deficits, and predict lesions using the stepping test.

Tags

6-hydroxydopamineParkinson’s DiseaseRat ModelNigrostriatal LesionsMedial Forebrain BundleStepping TestMotor DeficitsDopaminergic NeuronsSubstantia NigraNeurodegeneration

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