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Journal / Neuroscience / 使用光遗传学逆转大鼠的神经可塑性并抑制可卡因的寻找…
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使用光遗传学逆转大鼠的神经可塑性并抑制可卡因的寻找
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使用光遗传学逆转大鼠的神经可塑性并抑制可卡因的寻找

Article DOI: 10.3791/63185-v • 09:43 min • October 5th, 2021
October 5th, 2021 •
1,2, 1, 1
1Department of Psychiatry, University of Pittsburgh, 2Department of Psychiatry, Rutgers University

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这里描述的方法概述了用于在大鼠行为相关回路中以光遗传学逆转可卡因诱导的可塑性的程序。丘脑-杏仁核突触的持续低频光刺激可诱发长期抑郁（LTD）。在经历可卡因的大鼠中 体内光遗传 诱导的LTD导致随后的线索动机药物寻求减弱。

Tags

神经科学，第176期，长期抑郁症，恢复，杏仁核，光遗传学，神经调控
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