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Terminal H-reflex Measurements in Mice

Article DOI: 10.3791/63304-v • 05:38 min • June 16th, 2022
June 16th, 2022 •
*1, *2, 2, 1,3, 1
1Faculty of Medicine and University Hospital Cologne, Department of Neurology, University of Cologne, 2Department for Animal Physiology, Institute for Zoology, Biocenter Cologne, University of Cologne, 3Cognitive Neuroscience, Institute of Neuroscience and Medicine (INM-3), Research Center Juelich
* These authors contributed equally

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The clinical evaluation of spasticity based on the Hoffmann reflex (H-reflex) and using electrical stimulation of peripheral nerves is an established method. Here, we provide a protocol for a terminal and direct nerve stimulation for H-reflex quantification in the mouse forepaw.

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Terminal H-reflex Measurements Mice Electrophysiological Validation Neuro Circuits Forepaw Protocol Quantification Transcutaneous Recordings Variability Disease Models Spinal Cord Injury Stroke Surgery Equipment Nerves Connective Tissue Blood Vessels Frederique Wieters Ph.D Student C57 Black/6J Mouse Heating Pad Anesthesia Breathing Stability Reflexes Measuring Electrodes Temperature Measurement Rectal Probe Eye Ointment Fur Removal Incision
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