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En model af omvendt vaskulær ombygning i pulmonal hypertension på grund af venstre hjertesygdom ved aorta debanding hos rotter
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En model af omvendt vaskulær ombygning i pulmonal hypertension på grund af venstre hjertesygdom ved aorta debanding hos rotter

Article DOI: 10.3791/63502-v • 07:41 min • March 1st, 2022
March 1st, 2022 •
1,2,3, 1,2,3, 2, 2, 2,3, *2,3, *1,3,4
1Department of Cardiothoracic and Vascular Surgery, German Heart Center Berlin (DHZB), 2Institute of Physiology, Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 3DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, 4Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health
* These authors contributed equally

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Den nuværende protokol beskriver en kirurgisk procedure for at fjerne stigende aortabånd i en rottemodel af pulmonal hypertension på grund af venstre hjertesygdom. Denne teknik studerer endogene mekanismer for omvendt ombygning i lungecirkulationen og det højre hjerte og informerer således strategier til at vende pulmonal hypertension og / eller højre ventrikulær dysfunktion.

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