小型猪视网膜下植入携带视网膜色素上皮细胞的载体：术前准备、手术技术及术后护理指南
3.1K 次观看
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被引用 1 次
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11:06 分钟
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2022年11月11日
DOI :10.3791/63505-v
2022年11月11日
•3.1K 次观看
Lyubomyr Lytvynchuk*1,2 , Zbynek Stranak*3 , Hana Studenovska4 , David Rais4 , Štěpán Popelka4 , Lucie Tichotová5,6 , Yaroslav Nemesh5,6 , Anastasiia Kolesnikova5,6 , Ruslan Nyshchuk5,6 , Anna Brymová5,6 , Zdeňka Ellederová5 , Jana Čížková5 , Jana Juhásová5 , Štefan Juhás5 , Pavla Jendelová7 , Richárd Nagymihály8 , Igor Kozak9 , Slaven Erceg10 , Susanne Binder11 , Brigitte Müller1 , Knut Stieger1 , Jan Motlik5 , Goran Petrovski*8 , Taras Ardan*5
1Eye Clinic, Department of Ophthalmology, University Hospital Giessen and Marburg GmbH, 2Karl Landsteiner Institute for Retinal Research and Imaging, 3Department of Ophthalmology, University Hospital Kralovske Vinohrady and Third Faculty of Medicine, Charles University in Prague, 4Institute of Macromolecular Chemistry, Czech Academy of Sciences, 5Institute of Animal Physiology and Genetics, Czech Academy of Sciences, 6Department of Cell Biology, Faculty of Science, Charles University, 7Institute of Experimental Medicine, Czech Academy of Sciences, 8Center for Eye Research, Department of Ophthalmology, Oslo University Hospital and Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, 9Moorfields Eye Hospitals UAE, 10Stem Cell Therapies in Neurodegenerative Diseases Lab, Research Center “Principe Felipe”, 11Eye Center Donaustadt, Department of Ophthalmology, Sigmund Freud University
* These authors contributed equally
视网膜色素上皮（RPE）的视网膜下植入是治疗退行性视网膜疾病最有前景的方法之一。然而，在大眼动物模型上开展临床前研究仍具有挑战性。本报告提供了将RPE细胞搭载于细胞载体上进行视网膜下移植至小型猪的实验操作指南。
Chapters in this video
0:00
Introduction
1:53
Surgical Procedure
6:42
Enucleation of the Eye Post Mortem After Euthanasia
8:08
Representative Results
9:53
Conclusions
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