Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

Victoria G. Muir; Margaret E. Prendergast; Jason  A. Burdick

doi:10.3791/63867

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Fragmenting Bulk Hydrogels and Processing into Granular Hydrogels for Biomedical Applications

破碎散装水凝胶并加工成颗粒状水凝胶，用于生物医学应用

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10:18 min

May 17, 2022

DOI: 10.3791/63867-v

Victoria G. Muir¹, Margaret E. Prendergast¹, Jason A. Burdick^1,2,3

¹Department of Bioengineering, School of Engineering and Applied Sciences,University of Pennsylvania, ²BioFrontiers Institute,University of Colorado Boulder, ³Department of Chemical and Biological Engineering, College of Engineering and Applied Science,University of Colorado Boulder

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这项工作描述了通过挤出破碎制造微凝胶，将微凝胶加工成可注射的颗粒水凝胶，并将颗粒水凝胶用作生物医学应用的挤出印刷油墨的简单，适应性强且低成本的方法。

颗粒水凝胶是一类令人兴奋的新型生物材料，具有许多有利的特性。我们希望通过分享这些方法，我们可以增加用于生物医学应用的颗粒水凝胶的获取和创新。这种技术简单，成本低，易于适应许多化学品，几乎可以在任何实验室中实施。

将3毫升注射器与水凝胶前体溶液一起加载。从空的3毫升注射器背面取下柱塞，并在注射器桶的顶部添加一个吸头盖。使用1， 000微升移液器将水凝胶前体溶液转移到带有吸头盖的注射器桶中。

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