Network Pharmacology Prediction and Experimental Validation of <em>Trichosanthes</em>-<em>Fritillaria thunbergii</em> Action Mechanism Against Lung Adenocarcinoma

Xu-yi Zhao; Yun-yue Yang; Jing-li Feng; Cui-ling Feng

doi:10.3791/64847

JoVE Journal
Medicine

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JoVE Journal Medicine

Network Pharmacology Prediction and Experimental Validation of Trichosanthes–Fritillaria thunbergii Action Mechanism Against Lung Adenocarcinoma

毛滴虫对肺腺癌作用机制的网络药理学预测及实验验证

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13:18 min

March 3, 2023

DOI: 10.3791/64847-v

Xu-yi Zhao¹, Yun-yue Yang¹, Jing-li Feng¹, Cui-ling Feng²

¹Dongzhimen Hospital affiliated to Beijing University of Chinese Medicine, ²Traditional Chinese Medicine Department,Peking University People's Hospital

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本研究基于网络药理学和实验验证，揭示了毛滴虫治疗肺腺癌的机制 。该研究还表明，PI3K / AKT信号通路在 Trichosanthes-Fritillaria thunbergii 治疗肺腺癌中的作用中起着至关重要的作用。

中药，我们来谈谈靶材多组分的特点。这是网络和生物研究的最基本框。我们演示了将降低阈值的技术。

网络药理学是系统分析技术，构建了多因素相互作用网络工作的工具。它可以有效地预测中医药在网络药理学数据中来自数据库的单一途径，虽然无法预测与药物、蛋白质的关系，这仍需要通过后续实验来验证。开始打开HERB数据库，以瓜刘和哲碧木为关键词，获取两种药物的成分。

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