An Improved Technique for Trimethylamine Detection in Animal-Derived Medicine by Headspace Gas Chromatography-Tandem Quadrupole Mass Spectrometry

Hui Ye; Xuemei Liu; JiaBao Liao; Haozhou Huang; Lin Huang; Yang Bao; Hongyan Ma; Junzhi Lin; Xiaoming Bao; Dingkun Zhang; Runchun Xu

doi:10.3791/65291

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An Improved Technique for Trimethylamine Detection in Animal-Derived Medicine by Headspace Gas Chromatography-Tandem Quadrupole Mass Spectrometry

一种改进的顶空气相色谱-串联四极杆质谱法检测动物源性药物中三甲胺的技术

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04:19 min

March 10, 2023

DOI: 10.3791/65291-v

Hui Ye¹, Xuemei Liu¹, JiaBao Liao², Haozhou Huang³, Lin Huang¹, Yang Bao¹, Hongyan Ma¹, Junzhi Lin⁴, Xiaoming Bao⁵, Dingkun Zhang¹, Runchun Xu¹

¹State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy School,Chengdu University of Traditional Chinese Medicine, ²China Resources Sanjiu Modern Chinese Medicine Pharmaceutical Co., Ltd, ³Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine, ⁴TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine, ⁵Shimadzu (China) Co., Ltd

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本文描述了一种适用于测定动物源性药物中三甲胺（TMA）的顶空气相色谱-串联四极杆质谱（HS-GC-MS/MS）方法。该方案包括样品预处理、顶空处理、分析条件、方法验证以及动物源性药物中TMA的测定。

我们的研究范围是动物医学中鱼味变化的物质基础。该方案提供了一种简单的预处理方法和动物药物中三甲胺的准确检测。该协议的简单预处理方法和HS-GC质量/质量数的编程参数需要进一步优化，我们还有很多工作要做。

我们的方案采用气相色谱质量/质量数的多方向监测模式，结合独特、简单的预处理，不仅是三甲胺分析的第一个预处理，也是第一个要使用的分析模式。

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化学第193期动物源性药物三甲胺鱼腥味顶空气相色谱-串联四极杆质谱