外泌体负载胶原贴片联合非体外循环冠状动脉旁路移植术治疗慢性心肌缺血的猪外科模型
1.7K 次观看
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被引用 7 次
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05:25 分钟
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2023年9月15日
DOI :10.3791/65553-v
2023年9月15日
•1.7K 次观看
Rishav Aggarwal1 , Annie Shao1 , Koray N. Potel2 , Laura Hocum Stone1 , Cory Swingen1 , Christin Wright1 , Edward O. McFalls3 , Tammy A. Butterick4,5 , Rosemary F. Kelly1
1Department of Surgery, University of Minnesota, 2School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, 3Cardiology, Richmond VA Medical Center, 4Department of Research Service, Center for Veterans Research and Education, Veterans Affairs Health Care System, 5Department of Neuroscience, University of Minnesota
本研究介绍了一种由于进行性冠状动脉狭窄导致慢性心肌缺血的猪外科模型，该模型在无心肌梗死的情况下引起心脏功能受损。缺血发生后，动物接受非体外循环冠状动脉旁路移植术，并在心外膜放置富含干细胞来源外泌体的胶原贴片作为辅助治疗。该辅助疗法可改善心肌功能和恢复。
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