Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

Stine  B. Nymand; Jacob Peter Hartmann; Helene Louise Hartmeyer; Iben E. Rasmussen; Amalie Bach Andersen; Milan Mohammad; Susan Al-Atabi; Birgitte Hanel; Ulrik Winning Iepsen; Jann Mortensen; Ronan M. G. Berg

doi:10.3791/65871

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JoVE Journal Medicine

Dual Test Gas Pulmonary Diffusing Capacity Measurement During Exercise in Humans Using the Single-Breath Method

使用单次呼吸法测量人体运动期间的双重测试气体肺弥散能力

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08:44 min

February 2, 2024

DOI: 10.3791/65871-v

Stine B. Nymand¹, Jacob Peter Hartmann^1,2,3, Helene Louise Hartmeyer¹, Iben E. Rasmussen¹, Amalie Bach Andersen¹, Milan Mohammad¹, Susan Al-Atabi³, Birgitte Hanel³, Ulrik Winning Iepsen^1,4, Jann Mortensen^3,5, Ronan M. G. Berg^1,2,3,6

¹Centre for Physical Activity Research,Copenhagen University Hospital - Rigshospitalet, ²Department of Biomedical Sciences, Faculty of Health and Medical Sciences,University of Copenhagen, ³Department of Clinical Physiology and Nuclear Medicine,Copenhagen University Hospital - Rigshospitalet, ⁴Department of Anesthesiology and Intensive Care,Hvidovre Hospital, ⁵Department of Clinical Medicine, Faculty of Health and Medical Sciences,University of Copenhagen, ⁶Neurovascular Research Laboratory, Faculty of Life Sciences and Education,University of South Wales

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该方案提出了一种评估肺泡毛细血管储备的方法，该方法通过联合单次呼吸测量运动期间对一氧化碳（D_L，CO）和一氧化氮（D_L，NO）的扩散能力进行测量。在锻炼过程中使用该技术的假设和建议构成了本文的基础。

我们的研究重点是各种疾病状态下肺气体交换受损的机制，以及如何将这些知识用于诊断和靶向治疗。我们的目标是通过运动期间的弥散能力测量来评估肺泡毛细血管储备，从而完善对急性运动适应的理解。常规肺功能测试（如动态肺活量测定）和休息期间的弥散量测量，只能提供有关肺功能限制和对急性运动的适应的有限信息。

我们的方案通过引入一种更全面且与生理相关的测量方法来评估肺泡毛细血管储备，从而解决了这一差距。通过对运动过程中的肺功能进行更详细的分析，本研究有助于开发肺部疾病的靶向诊断和治疗策略，提高临床管理和治疗效果。通过这种技术，我们的研究将具体阐明肺气体交换限制如何导致慢性肺病的病理生理学，以及运动训练如何影响慢性肺病。

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