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JoVE Journal
Medicine
基于GEO数据集和网络药理学的石都高治疗肛门湿疹的疗效及潜在通路机制
基于GEO数据集和网络药理学的石都高治疗肛门湿疹的疗效及潜在通路机制
JoVE Journal
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JoVE Journal Medicine
The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

基于GEO数据集和网络药理学的石都高治疗肛门湿疹的疗效及潜在通路机制

Full Text
1,046 Views
12:34 min
January 12, 2024

DOI: 10.3791/66453-v

Song Wang*1,2,3, Wanyi Xiao*1,2, Anqi He1,2, Jinyan Jia1,2, Gang Liu1,2

1Department of General Surgery,Tianjin Medical University General Hospital, 2Tianjin General Surgery Institute, 3Department of General Surgery,Zibo Municipal Hospital

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Summary

这项调查工作旨在通过网络药理学和基因表达综合 (GEO) 数据集的协同整合来阐明局部给药的机制。本文评价了石度高(SDG)治疗肛门湿疹的可行性、靶点和机制。

Transcript

1 本文评价了十度高治疗肛门湿疹的可行性、靶点 2 和机制。3 网络药理学和 GEO 数据库分析 4 证实了 SDG 5 治疗肛门湿疹的多靶点性质,6 特别是通过调节 TNF 和 APK 14、7 和 CASP3、8 它们是 TNF 9 和 MAPK 信号通路中的关键枢纽靶点。10 这些资金为进一步研究可持续发展目标提供了明确的方向 1112 肛门湿疹的治疗机制,13 同时强调其潜力 14 作为这种使人衰弱的疾病的有效治疗方法 15。

16 机制研究被认为是17 草药处方调查中最复杂的方面 18。19 网络药理学目前允许以药物为中心的不同方面 20,21 从传统 22 到现代生物医学的范式转变,23 并完善中医发展。24 本研究将网络药理学 25 与 GEO 数据集相结合,以辨别局部药物机制。

26 在这项研究中,纯数据生成方法27 通过结合修饰的疾病来最大化数据利用率 28,29 特别是对于一些难以 30 建立动物模型的疾病。31 在线数据主要用于预测 32 并验证疾病和药物靶点 33 ,从而收集研究方向 34 并为后续实验验证奠定良好的基础 35。

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