Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues

Xingyuan Sun; Junli Chang; Chujie Zhou; Peng Zhao; Suxia Guo; Junjie Tong; Yongjun Wang; Yanping Yang

doi:10.3791/66491

JoVE Journal
Cancer Research

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JoVE Journal Cancer Research

Establishment of Patient-Derived Xenograft Mouse Model with Human Osteosarcoma Tissues

人骨肉瘤组织患者来源的异种移植小鼠模型的建立

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02:35 min

March 22, 2024

DOI: 10.3791/66491-v

Xingyuan Sun*^1,2, Junli Chang*^1,2, Chujie Zhou^1,2, Peng Zhao^1,2, Suxia Guo^1,2, Junjie Tong^1,2, Yongjun Wang^1,2, Yanping Yang^1,2

¹Longhua Hospital,Shanghai University of Traditional Chinese Medicine, ²Key Laboratory of theory and therapy of muscles and bones,Ministry of Education

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本方案描述了使用人骨肉瘤组织建立患者来源的异种移植物（PDX）小鼠模型的方法。

本研究精心复制了免疫缺陷小鼠人骨肉瘤组织生长的横向进展，为研究骨肉瘤的生长、耐药、复发和转移提供了一个平台。我们实现了使用人骨肉瘤组织建立患者来源的异种移植模型所涉及的程序步骤，从而为骨肉瘤的临床前研究提供建议。这种技术准确性模拟了人类癌症并保持原发肿瘤相似性，有助于探索骨肉瘤生物学和治疗效果。

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关键词:患者来源的异种移植物 PDX 骨肉瘤骨肿瘤小儿癌症临床前模型肿瘤异质性耐药性转移个性化医疗