Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

Yunyuan Shao; Shuxuan Ye; Jiayin Feng; Fangyan Wang; Anqi Jin; Lanjie Lei; Wenjie Pan

doi:10.3791/66871

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Preparation of Cross-Linked Sodium Alginate Microspheres with Different Metal Ions Using the Microfluidic Electrospray Technology

利用微流控电喷雾技术制备具有不同金属离子的交联海藻酸钠微球

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07:24 min

June 7, 2024

DOI: 10.3791/66871-v

Yunyuan Shao*¹, Shuxuan Ye*¹, Jiayin Feng¹, Fangyan Wang¹, Anqi Jin¹, Lanjie Lei¹, Wenjie Pan²

¹Key Laboratory of Artificial Organs and Computational Medicine in Zhejiang Province, Institute of Translational Medicine,Zhejiang Shuren University, ²The Third Affiliated Hospital of Wenzhou Medical University

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该方案描述了使用用于药物载体设计的微流体装置制备与不同金属离子交联的海藻酸钠微球。还研究了这些微球的抗菌特性和缓慢的药物释放。

氢微球的特点是相容性好、设计灵活性高、定制化程度高。它们在生物医学领域具有广泛的应用保护器，例如治疗药物递送和 TC 修复发现的构建。在这项研究中，我们使用简单的微流控装置制备了氢微球。

最近，我们一直在尝试使用载有一些中医小分子的氢微球来促进所有愈合。在这项研究中，我们发现锌和铜离子交联海藻酸钠微球具有良好的抗菌性能，因此铜 ARGMS 和锌 ARGMS 适用于治疗细菌感染性疾病。

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生物工程第 208 期水凝胶微流体电喷雾金属离子交联药物递送抗菌特性生物相容性