A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion

Rong Ma; Hongyan Yang; Jianlong Liang; Danni Lu; Qian Xie; Xuxin Zeng; Jialiang Guo

doi:10.3791/67060

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A Modified Model Preparation for Middle Cerebral Artery Occlusion Reperfusion

大脑中动脉闭塞再灌注的改良模型制备

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04:18 min

May 31, 2024

DOI: 10.3791/67060-v

Rong Ma¹, Hongyan Yang¹, Jianlong Liang¹, Danni Lu², Qian Xie¹, Xuxin Zeng¹, Jialiang Guo¹

¹School of Medicine,Foshan University, ²School of Medicine,Shaanxi University of International Trade and Commerce

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该协议描述了准备通过颈总动脉进行大脑中动脉闭塞再灌注的过程。

我们的研究范围是脑缺血的建模程序。我们尝试从颈总动脉引入丝线并用细丝线结扎切口，维持颈总动脉和颈外动脉的再灌注。小泉法被认为再灌注不足，但 Longa 法被认为会影响主肌的血液供应。

操作复杂，对初学者不友好。我们的协议解决了上述问题，并提供了一种替代方法。我们的方案使更多从业者更容易掌握脑缺血建模，并快速发现潜在的神经保护药物。

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关键字:MCAO/R 模型大脑中动脉闭塞再灌注中风缺血性神经损伤改良模型制备激光散斑流成像 Longa 量表改良神经严重程度评分 TTC 染色免疫荧光标记