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JoVE Journal
Behavior
小鼠间歇性暴饮暴食模型
小鼠间歇性暴饮暴食模型
JoVE Journal
Behavior
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JoVE Journal Behavior
Intermittent Binge-Intake Model in Mice

小鼠间歇性暴饮暴食模型

Full Text
1,744 Views
05:15 min
January 10, 2025

DOI: 10.3791/67560-v

Sonia Ortega-Tinoco1, Rodrigo Acosta-Luna1, Leticia Verdugo-Díaz1, Jorge Bravo-Martinez1, Salvador Hernández-López1, Julieta Garduño1

1Department of Physiology, Faculty of Medicine,Universidad Nacional Autónoma de México (UNAM)

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Please note that some of the translations on this page are AI generated. Click here for the English version.

使用间歇性访问 M&M's(一种由脂肪和糖制成的非常可口的食物)在小鼠中建立了暴饮暴食模型。与持续或无法获得这种食物的小鼠相比,间歇性获得这种高脂肪、高糖食物的小鼠表现出类似压力的行为、热量摄入增加,并且更喜欢该食物而不是标准食物。

本研究调查了食物供应模式对暴饮暴食行为和暴饮暴食症 (BED) 中焦虑样行为的影响。利用新颖的 M&M's 小鼠模型,我们比较了连续与间歇性获得可口食物的效果。目标是为基本的暴饮暴食症研究开发可访问的模型。

我们的协议提供了一种快速、简单且可访问的基于 M&M 的模型。它通过开放领域的测试结果进行验证,有效地复制了类似焦虑的行为。此外,它为研究暴饮暴食模型提供了有效且具有成本效益的方法,为进一步研究 BED 等疾病的潜在神经机制铺平了道路。

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间歇性暴饮暴食模型 肥胖 暴食症 (BED) 高热量食物 强迫性饮食行为 C57BL/6 小鼠 喂养时间表 焦虑样行为 高度可口的食物 (HPF) 卡路里消耗 情绪状态 代谢后果 标准化模型 治疗干预

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