Chuan-ju Liu Department of Orthopaedic Surgery & Department of Cell Biology NYU School of Medicine Biography Publications Institution JoVE Articles Chuan-ju LiuProfessor of Orthopaedic Surgery and Cell Biology Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS. Publications Progranulin Promotes Diabetic Fracture Healing in Mice with Type 1 Diabetes Annals of the New York Academy of Sciences. Aug, 2019 | Pubmed ID: 31423598 Fexofenadine Inhibits TNF Signaling Through Targeting to Cytosolic Phospholipase A2 and is Therapeutic Against Inflammatory Arthritis Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31302596 Progranulin: A Conductor of Receptors Orchestra, a Chaperone of Lysosomal Enzymes and a Therapeutic Target for Multiple Diseases Cytokine & Growth Factor Reviews. 02, 2019 | Pubmed ID: 30733059 Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review JBJS Reviews. Jan, 2019 | Pubmed ID: 30694878 Targeting Tumor Necrosis Factor Receptors in Ankylosing Spondylitis Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30008173 Brain-penetrant Heat Shock Protein Amplifier Arimoclomol Enhances GCase Activity in in Vitro Gaucher Disease Models EBioMedicine. 12, 2018 | Pubmed ID: 30522930 Progranulin Associates with Hexosaminidase A and Ameliorates GM2 Ganglioside Accumulation and Lysosomal Storage in Tay-Sachs Disease Journal of Molecular Medicine (Berlin, Germany). Dec, 2018 | Pubmed ID: 30341570 Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956284 Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor Arthritis & Rheumatology (Hoboken, N.J.). 11, 2018 | Pubmed ID: 29750395 Molecular Regulations and Therapeutic Targets of Gaucher Disease Cytokine & Growth Factor Reviews. 06, 2018 | Pubmed ID: 29699937 P204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice EBioMedicine. Mar, 2018 | Pubmed ID: 29472103 Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease EBioMedicine. Feb, 2018 | Pubmed ID: 29396296 Multifunctional Molecule ERp57: From Cancer to Neurodegenerative Diseases Pharmacology & Therapeutics. 01, 2018 | Pubmed ID: 28723413 Progranulin: A Key Player in Autoimmune Diseases Cytokine. 01, 2018 | Pubmed ID: 27527809 Progranulin Derivative Atsttrin Protects Against Early Osteoarthritis in Mouse and Rat Models Arthritis Research & Therapy. Dec, 2017 | Pubmed ID: 29258611 Progranulin Acts As a Shared Chaperone and Regulates Multiple Lysosomal Enzymes Genes & Diseases. Sep, 2017 | Pubmed ID: 28944282 Foxo4- and Stat3-dependent IL-10 Production by Progranulin in Regulatory T Cells Restrains Inflammatory Arthritis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2017 | Pubmed ID: 28011648 Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease EBioMedicine. Nov, 2016 | Pubmed ID: 27789271 Association Between Progranulin and Gaucher Disease EBioMedicine. Sep, 2016 | Pubmed ID: 27515686 Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling Arthritis & Rheumatology (Hoboken, N.J.). 12, 2016 | Pubmed ID: 27428882 Extracellular Matrix Protein 1, a Direct Targeting Molecule of Parathyroid Hormone-related Peptide, Negatively Regulates Chondrogenesis and Endochondral Ossification Via Associating with Progranulin Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27075243 Progranulin Suppresses Titanium Particle Induced Inflammatory Osteolysis by Targeting TNFα Signaling Scientific Reports. Feb, 2016 | Pubmed ID: 26864916 Does Progranulin Account for the Opposite Effects of Etanercept and Infliximab/adalimumab in Osteoarthritis?: Comment on Olson Et Al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture" Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2016 | Pubmed ID: 26519939 Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice Scientific Reports. Mar, 2015 | Pubmed ID: 25777988 Overexpression of ADAMTS-7 Leads to Accelerated Initiation and Progression of Collagen-induced Arthritis in Mice Molecular and Cellular Biochemistry. Jun, 2015 | Pubmed ID: 25742929 Progranulin Protects Against Osteoarthritis Through Interacting with TNF-α and β-Catenin Signalling Annals of the Rheumatic Diseases. Dec, 2015 | Pubmed ID: 25169730 Progranulin Facilitates Conversion and Function of Regulatory T Cells Under Inflammatory Conditions PloS One. 2014 | Pubmed ID: 25393765 PGRN Protects Against Colitis Progression in Mice in an IL-10 and TNFR2 Dependent Manner Scientific Reports. Nov, 2014 | Pubmed ID: 25387791 ADAMTS-18: a Metalloproteinase with Multiple Functions Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896365 Three TNFR-binding Domains of PGRN Act Independently in Inhibition of TNF-alpha Binding and Activity Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896343 Progranulin Inhibition of TNFα Immunology and Cell Biology. Feb, 2014 | Pubmed ID: 24518982 Progranulin Directly Binds to the CRD2 and CRD3 of TNFR Extracellular Domains FEBS Letters. Nov, 2013 | Pubmed ID: 24070898 ADAMTS-7 Forms a Positive Feedback Loop with TNF-α in the Pathogenesis of Osteoarthritis Annals of the Rheumatic Diseases. Dec, 2013 | Pubmed ID: 23928557 The Promotion of Bone Healing by Progranulin, a Downstream Molecule of BMP-2, Through Interacting with TNF/TNFR Signaling Biomaterials. Sep, 2013 | Pubmed ID: 23746860 Progranulin Deficiency Exaggerates, Whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice FEBS Letters. Jun, 2013 | Pubmed ID: 23669357 Prevention of Atrophic Nonunion by the Systemic Administration of Parathyroid Hormone (PTH 1-34) in an Experimental Animal Model Journal of Orthopaedic Trauma. Dec, 2012 | Pubmed ID: 22932751 Progranulinの:成長因子、小説TNFRリガンドと薬ターゲット Pharmacology & Therapeutics. Jan, 2012 | Pubmed ID: 22008260 GEPは、骨格筋分化を制御するのに新しいメディエーターとしてMyoDはと行為との負のフィードバックループを構成 Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 22179841 Progranulinの:関節リウマチのための有望な治療ターゲット FEBS Letters. Dec, 2011 | Pubmed ID: 21550343 成長因子progranulinのは、TNF受容体に結合するとマウスの炎症性関節炎に対する治療です。 Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393509 軟骨オリゴマーマトリックスタンパク質は、骨形成タンパク質-2と相互作用することにより血管平滑筋石灰化を阻害する Circulation Research. Apr, 2011 | Pubmed ID: 21350216 リウマチにおけるADAMTSsの役割 Protein & Cell. Jan, 2010 | Pubmed ID: 21203996 GEPは、ローカル成長因子は、歯牙形成とエナメル質形成に重要である International Journal of Biological Sciences. 2010 | Pubmed ID: 21152114 に関連付けられ、クリーブ骨形成タンパク質-2はin Vitroで肥大骨折偽関節組織で上昇しているマトリックスメタロプロテアーゼ Journal of Orthopaedic Trauma. Sep, 2010 | Pubmed ID: 20736794 軟骨オリゴマーマトリックスタンパク質と細胞外マトリックスタンパク質1仲介軟骨骨の成長の間の相互作用 Matrix Biology : Journal of the International Society for Matrix Biology. May, 2010 | Pubmed ID: 20138147 グラニュリンEpithelin前駆体:軟骨形成にErk1 / 2のシグナリングとJunBの転写因子をアクティブに骨形態形成タンパク質2 - 誘導成長因子 FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2010 | Pubmed ID: 20124436 軟骨オリゴマーマトリックスタンパク質は、Alpha(7)ベータ(1)インテグリンとの相互作用によって血管平滑筋細胞の収縮表現型を維持 Circulation Research. Feb, 2010 | Pubmed ID: 20019333 パイロット·スタディ:BMP-7の発現と、いくつかのBMPアンタゴニストのレベルは、偽関節破壊に不可欠な役割を果たす可能性があります Clinical Orthopaedics and Related Research. Dec, 2009 | Pubmed ID: 19597895 ADAMTS-7、PTHrPの直接のターゲットに悪影響との関連付けとGEP成長因子を不活性化することによって軟骨内骨の成長を調節する Molecular and Cellular Biology. Aug, 2009 | Pubmed ID: 19487464 骨格形成におけるマイクロRNA Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273234 はmiR-199a、骨形成タンパク質2 - 応答マイクロRNAは、直接あるSmad1をターゲット経由軟骨形成を調節する The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19251704 ADAMTS-7を仲介気球負傷したラットの動脈における血管平滑筋細胞の移動と新生内膜形成 Circulation Research. Mar, 2009 | Pubmed ID: 19168437 関節リウマチの病態におけるADAMTS-7とADAMTS-12の役割 Nature Clinical Practice. Rheumatology. Jan, 2009 | Pubmed ID: 19098927 細胞の増殖と分化の多機能調節因子としてのP204、P200ファミリー蛋白質、 Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027346 Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-macroglobulin Osteoarthritis and Cartilage. Nov, 2008 | Pubmed ID: 18485748 P204タンパク質は、Idヘリックス - ループ - ヘリックス蛋白質によってコア結合因子α-1媒介骨分化の阻害を克服 Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287524 RbAp48は、子宮頸がんでヒトパピローマウイルス·タイプ16の形質転換活性を制御する重要なメディエーターである The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17616526 IFI16は腫瘍形成と骨や軟骨の腫瘍細胞の細胞増殖を抑制 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569615 Sox9をによる軟骨オリゴマーマトリックスタンパク質の転写活性化、Sox5、とSox6転写因子やコアクチベーターCBP/p300 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17485346 網膜芽細胞腫タンパク質は、それによってその活性を増加させる転写因子Cbfa1のP204タンパク質をリンク骨形成の本質的なメディエーターである The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17439944 タンパク質 - タンパク質相互作用と人間の有機溶質トランスポーターの膜局在 American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2007 | Pubmed ID: 17332473 グラニュリン-epithelin前駆体(GEP)と軟骨オリゴマーマトリックスプロテインAssociatesとGEP刺激軟骨細胞増殖を増強する The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17307734 ADAMTS-12と結合し、軟骨オリゴマーマトリックス蛋白質を低下する The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16611630 ADAMTS-7:直接に結合し、軟骨オリゴマーマトリックスタンパク質を低下するメタロプロテアーゼ FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16585064 P204タンパク質は、Idタンパク質による心筋細胞拍動をへP19マウス胚性癌細胞の分化の阻害を克服 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556596 P204は、心筋細胞を打つまでP19マウス胚性癌細胞の分化に必要されています。その発現は心臓GATA4、Nkx2.5、とTBX5タンパク質によって活性化されてい The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556595 股関節と膝関節置換術に続いてステム周囲感染のマーカーとしての血清インターロイキン-6 The Journal of Bone and Joint Surgery. American Volume. Sep, 2005 | Pubmed ID: 16140805 インターフェロン誘導性P204タンパク質はCbfa1の転写コアクチベーターとして作用し、骨芽細胞分化を強化 The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15557274 白血病/リンパ腫関連因子、POZドメインを含む転写抑制因子は、ヒストン脱アセチル-1と相互作用し、軟骨オリゴマーマトリックスタンパク質の遺伝子発現と軟骨形成を阻害する The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15337766 軟骨オリゴマーマトリックスタンパク質遺伝子のサイレンサーエレメントは軟骨細胞特異的発現を調節する Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2004 | Pubmed ID: 15183430 蛋白質 - 蛋白質相互作用と細胞内輸送:回腸Na +依存性胆汁酸輸送と液胞プロトンポンプの16-kDaのサブユニットCの協会 The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14752118 線維芽細胞増殖因子による心臓ナトリウムチャネルNav1.5相同因子1Bの変調 The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12401812 MyoDは誘導性P204タンパク質は、Idタンパク質によって筋芽細胞の分化の阻害を克服 Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940648 ラパマイシン/mTOR相互作用を研究するための半定量薬物アフィニティ応答性標的安定性(DARTS)アッセイ Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemie 変形性関節症におけるプログラの保護的役割を調査するためにマウスの外科的誘発モデルの確立 Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Biotechnik 成長因子Progranulinと相互作用するタンパク質を識別するように変更酵母ツーハイブリッドシステム Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biologie
ラパマイシン/mTOR相互作用を研究するための半定量薬物アフィニティ応答性標的安定性(DARTS)アッセイ Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemie
変形性関節症におけるプログラの保護的役割を調査するためにマウスの外科的誘発モデルの確立 Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Biotechnik
成長因子Progranulinと相互作用するタンパク質を識別するように変更酵母ツーハイブリッドシステム Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biologie