Ekaterina Rogaeva Tanz Centre for Research in Neurodegenerative Diseases University of Toronto Biography Publications Institution JoVE Articles Ekaterina Rogaeva has not added a biography. If you are Ekaterina Rogaeva and would like to personalize this page please email our Author Liaison for assistance. Publications Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 Clinical Reasoning: A 42-year-old Man with Unilateral Leg Weakness Neurology. Mar, 2018 | Pubmed ID: 29555890 Mutation Analysis of CHCHD2 and CHCHD10 in Italian Patients with Mitochondrial Myopathy Neurobiology of Aging. Feb, 2018 | Pubmed ID: 29519717 Actigraphy Detects Greater Intra-Individual Variability During Gait in Non-Manifesting LRRK2 Mutation Carriers Journal of Parkinson's Disease. 2018 | Pubmed ID: 29480219 An APOE-independent Cis-eSNP on Chromosome 19q13.32 Influences Tau Levels and Late-onset Alzheimer's Disease Risk Neurobiology of Aging. Jan, 2018 | Pubmed ID: 29395286 Unaffected Mosaiccase: RNA Foci, Dipeptide Proteins, but Upregulated C9orf72 Expression Neurology. Jan, 2018 | Pubmed ID: 29282338 Investigating the Genetic Architecture of Dementia with Lewy Bodies: a Two-stage Genome-wide Association Study The Lancet. Neurology. Jan, 2018 | Pubmed ID: 29263008 Loss of CHCHD10-CHCHD2 Complexes Required for Respiration Underlies the Pathogenicity of a CHCHD10 Mutation in ALS Human Molecular Genetics. Jan, 2018 | Pubmed ID: 29121267 Clinical and Neuropathological Features of ALS/FTD with TIA1 Mutations Acta Neuropathologica Communications. Dec, 2017 | Pubmed ID: 29216908 Dysregulation of Chromatin Remodelling Complexes in Amyotrophic Lateral Sclerosis Human Molecular Genetics. Nov, 2017 | Pubmed ID: 28973294 Sex Differences in the Prevalence of Genetic Mutations in FTD and ALS: A Meta-analysis Neurology. Oct, 2017 | Pubmed ID: 28916533 Ultra-rare Mutations Insegregate in Caribbean Hispanic Families with Alzheimer Disease Neurology. Genetics. Oct, 2017 | Pubmed ID: 28852706 Time-course Global Proteome Analyses Reveal an Inverse Correlation Between Aβ Burden and Immunoglobulin M Levels in the APPNL-F Mouse Model of Alzheimer Disease PloS One. 2017 | Pubmed ID: 28832675 TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics Neuron. Aug, 2017 | Pubmed ID: 28817800 Rare Coding Variants in PLCG2, ABI3, and TREM2 Implicate Microglial-mediated Innate Immunity in Alzheimer's Disease Nature Genetics. 09, 2017 | Pubmed ID: 28714976 NeuroChip, an Updated Version of the NeuroX Genotyping Platform to Rapidly Screen for Variants Associated with Neurological Diseases Neurobiology of Aging. Sep, 2017 | Pubmed ID: 28602509 DNA Methylation Age-acceleration is Associated with Disease Duration and Age at Onset in C9orf72 Patients Acta Neuropathologica. Aug, 2017 | Pubmed ID: 28439722 Collagenosis of the Deep Medullary Veins: An Underrecognized Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction? Journal of Neuropathology and Experimental Neurology. 04, 2017 | Pubmed ID: 28431180 C9orf72 and ATXN2 Repeat Expansions Coexist in a Family with Ataxia, Dementia, and Parkinsonism Movement Disorders : Official Journal of the Movement Disorder Society. Jan, 2017 | Pubmed ID: 28124431 Genetic Analysis of CHCHD2 and CHCHD10 in Italian Patients with Parkinson's Disease Neurobiology of Aging. 05, 2017 | Pubmed ID: 28108040 A ZIP6-ZIP10 Heteromer Controls NCAM1 Phosphorylation and Integration into Focal Adhesion Complexes During Epithelial-to-mesenchymal Transition Scientific Reports. Jan, 2017 | Pubmed ID: 28098160 Heart Rate Variability in Leucine-rich Repeat Kinase 2-associated Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Jan, 2017 | Pubmed ID: 28071824 Characterizing Familial Corticobasal Syndrome Due to Alzheimer's Disease Pathology and PSEN1 Mutations Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2017 | Pubmed ID: 27743520 The ONDRISeq Panel: Custom-designed Next-generation Sequencing of Genes Related to Neurodegeneration NPJ Genomic Medicine. 2016 | Pubmed ID: 29263818 Drug Repositioning for Alzheimer's Disease Based on Systematic 'omics' Data Mining PloS One. 2016 | Pubmed ID: 28005991 Marked Differences in C9orf72 Methylation Status and Isoform Expression Between C9/ALS Human Embryonic and Induced Pluripotent Stem Cells Stem Cell Reports. 11, 2016 | Pubmed ID: 27773700 Does BDNF Val66Met Contribute to Preclinical Alzheimer's Disease? Brain : a Journal of Neurology. Oct, 2016 | Pubmed ID: 27671028 Analysis of C9orf72 Repeat Expansions in a Large International Cohort of Dementia with Lewy Bodies Neurobiology of Aging. Sep, 2016 | Pubmed ID: 27666590 Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-β40 and Amyloid-β42 Peptides and ABCA7 Transcription in Cell Culture Models Journal of Alzheimer's Disease : JAD. 06, 2016 | Pubmed ID: 27314524 Genetic and Epigenetic Study of ALS-discordant Identical Twins with Double Mutations in SOD1 and ARHGEF28 Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2016 | Pubmed ID: 27154192 C9orf72 Isoforms in Amyotrophic Lateral Sclerosis and Frontotemporal Lobar Degeneration Brain Research. 09, 2016 | Pubmed ID: 27134035 Mutation Analysis of the MS4A and TREM Gene Clusters In a case-control Alzheimer's Disease Data Set Neurobiology of Aging. 06, 2016 | Pubmed ID: 27084067 Novel GRN Mutations in Patients with Corticobasal Syndrome Scientific Reports. Mar, 2016 | Pubmed ID: 26961809 Analysis of C9orf72 in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis from Argentina Neurobiology of Aging. Apr, 2016 | Pubmed ID: 26925510 Genome-wide Analysis of Genetic Correlation in Dementia with Lewy Bodies, Parkinson's and Alzheimer's Diseases Neurobiology of Aging. Feb, 2016 | Pubmed ID: 26643944 Mutation Analysis of CHCHD2 in Canadian Patients with Familial Parkinson's Disease Neurobiology of Aging. Feb, 2016 | Pubmed ID: 26639156 MTHFSD and DDX58 Are Novel RNA-binding Proteins Abnormally Regulated in Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Jan, 2016 | Pubmed ID: 26525917 Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals JAMA Neurology. Nov, 2015 | Pubmed ID: 26366463 F-box/LRR-repeat Protein 7 is Genetically Associated with Alzheimer's Disease Annals of Clinical and Translational Neurology. Aug, 2015 | Pubmed ID: 26339675 The Prion Protein Controls Polysialylation of Neural Cell Adhesion Molecule 1 During Cellular Morphogenesis PloS One. 2015 | Pubmed ID: 26288071 Isoform-specific Antibodies Reveal Distinct Subcellular Localizations of C9orf72 in Amyotrophic Lateral Sclerosis Annals of Neurology. Oct, 2015 | Pubmed ID: 26174152 Mutation Analysis of C9orf72 in Patients with Corticobasal Syndrome Neurobiology of Aging. Oct, 2015 | Pubmed ID: 26166205 Rare Coding Mutations Identified by Sequencing of Alzheimer Disease Genome-wide Association Studies Loci Annals of Neurology. Sep, 2015 | Pubmed ID: 26101835 Jump from Pre-mutation to Pathologic Expansion in C9orf72 American Journal of Human Genetics. Jun, 2015 | Pubmed ID: 26004200 Drug Repositioning for Diabetes Based on 'omics' Data Mining PloS One. 2015 | Pubmed ID: 25946000 Mutation Analysis of CHCHD10 in Different Neurodegenerative Diseases Brain : a Journal of Neurology. Sep, 2015 | Pubmed ID: 25833818 Low Molecular Weight Species of TDP-43 Generated by Abnormal Splicing Form Inclusions in Amyotrophic Lateral Sclerosis and Result in Motor Neuron Death Acta Neuropathologica. Jul, 2015 | Pubmed ID: 25788357 The C9orf72 Repeat Expansion Itself is Methylated in ALS and FTLD Patients Acta Neuropathologica. May, 2015 | Pubmed ID: 25716178 Presymptomatic Cognitive and Neuroanatomical Changes in Genetic Frontotemporal Dementia in the Genetic Frontotemporal Dementia Initiative (GENFI) Study: a Cross-sectional Analysis The Lancet. Neurology. Mar, 2015 | Pubmed ID: 25662776 Convergent Genetic and Expression Data Implicate Immunity in Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jun, 2015 | Pubmed ID: 25533204 Rarity of the Alzheimer Disease-protective APP A673T Variant in the United States JAMA Neurology. Feb, 2015 | Pubmed ID: 25531812 Inbreeding Among Caribbean Hispanics from the Dominican Republic and Its Effects on Risk of Alzheimer Disease Genetics in Medicine : Official Journal of the American College of Medical Genetics. Aug, 2015 | Pubmed ID: 25394174 Coding Mutations in SORL1 and Alzheimer Disease Annals of Neurology. Feb, 2015 | Pubmed ID: 25382023 Mutation Analysis of Patients with Neurodegenerative Disorders Using NeuroX Array Neurobiology of Aging. Jan, 2015 | Pubmed ID: 25174650 Mutations in the CHCHD10 Gene Are a Common Cause of Familial Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Dec, 2014 | Pubmed ID: 25261972 Identical Twins with the C9orf72 Repeat Expansion Are Discordant for ALS Neurology. Oct, 2014 | Pubmed ID: 25209579 Effects of Multiple Genetic Loci on Age at Onset in Late-onset Alzheimer Disease: a Genome-wide Association Study JAMA Neurology. Nov, 2014 | Pubmed ID: 25199842 Genetic Analysis Implicates APOE, SNCA and Suggests Lysosomal Dysfunction in the Etiology of Dementia with Lewy Bodies Human Molecular Genetics. Dec, 2014 | Pubmed ID: 24973356 Frontotemporal Dementia and Its Subtypes: a Genome-wide Association Study The Lancet. Neurology. Jul, 2014 | Pubmed ID: 24943344 Gene-wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease PloS One. 2014 | Pubmed ID: 24922517 Hypermethylation of the CpG-island Near the C9orf72 G₄C₂-repeat Expansion in FTLD Patients Human Molecular Genetics. Nov, 2014 | Pubmed ID: 24908669 Mutations in the Matrin 3 Gene Cause Familial Amyotrophic Lateral Sclerosis Nature Neuroscience. May, 2014 | Pubmed ID: 24686783 Rare Coding Variants in the Phospholipase D3 Gene Confer Risk for Alzheimer's Disease Nature. Jan, 2014 | Pubmed ID: 24336208 Motor Neuron Disease and Frontotemporal Dementia: Sometimes Related, Sometimes Not Experimental Neurology. Dec, 2014 | Pubmed ID: 24246281 Meta-analysis of 74,046 Individuals Identifies 11 New Susceptibility Loci for Alzheimer's Disease Nature Genetics. Oct, 2013 | Pubmed ID: 24162737 Association Between Early-onset Parkinson Disease and 22q11.2 Deletion Syndrome: Identification of a Novel Genetic Form of Parkinson Disease and Its Clinical Implications JAMA Neurology. Nov, 2013 | Pubmed ID: 24018986 Evidence of Recessive Alzheimer Disease Loci in a Caribbean Hispanic Data Set: Genome-wide Survey of Runs of Homozygosity JAMA Neurology. Oct, 2013 | Pubmed ID: 23978990 Hypermethylation of the CpG Island Near the G4C2 Repeat in ALS with a C9orf72 Expansion American Journal of Human Genetics. Jun, 2013 | Pubmed ID: 23731538 A Multicenter Study of Glucocerebrosidase Mutations in Dementia with Lewy Bodies JAMA Neurology. Jun, 2013 | Pubmed ID: 23588557 Role of P73 in Alzheimer Disease: Lack of Association in Mouse Models or in Human Cohorts Molecular Neurodegeneration. Feb, 2013 | Pubmed ID: 23414597 Segmental Duplications in Genome-wide Significant Loci and Housekeeping Genes; Warning for GAPDH and ACTB Neurobiology of Aging. Jun, 2013 | Pubmed ID: 23238109 TREM2 Variants in Alzheimer's Disease The New England Journal of Medicine. Jan, 2013 | Pubmed ID: 23150934 A Multi-centre Clinico-genetic Analysis of the VPS35 Gene in Parkinson Disease Indicates Reduced Penetrance for Disease-associated Variants Journal of Medical Genetics. Nov, 2012 | Pubmed ID: 23125461 SQSTM1 Mutations in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis Neurology. Oct, 2012 | Pubmed ID: 22972638 Investigation of C9orf72 in 4 Neurodegenerative Disorders Archives of Neurology. Sep, 2012 | Pubmed ID: 22964832 Genetic Association of CR1 with Alzheimer's Disease: a Tentative Disease Mechanism Neurobiology of Aging. Dec, 2012 | Pubmed ID: 22819390 Epidemiology and Genetics of Frontotemporal Dementia: a Door-to-door Survey in Southern Italy Neurobiology of Aging. Dec, 2012 | Pubmed ID: 22819134 Large-scale Replication and Heterogeneity in Parkinson Disease Genetic Loci Neurology. Aug, 2012 | Pubmed ID: 22786590 LIV-1 ZIP Ectodomain Shedding in Prion-infected Mice Resembles Cellular Response to Transition Metal Starvation Journal of Molecular Biology. Sep, 2012 | Pubmed ID: 22687393 Genome-wide Survey of Large Rare Copy Number Variants in Alzheimer's Disease Among Caribbean Hispanics G3 (Bethesda, Md.). Jan, 2012 | Pubmed ID: 22384383 Both Common Variations and Rare Non-synonymous Substitutions and Small Insertion/deletions in CLU Are Associated with Increased Alzheimer Risk Molecular Neurodegeneration. 2012 | Pubmed ID: 22248099 Association Between Variants in IDE-KIF11-HHEX and Plasma Amyloid β Levels Neurobiology of Aging. Jan, 2012 | Pubmed ID: 20724036 A Hexanucleotide Repeat Expansion in C9ORF72 is the Cause of Chromosome 9p21-linked ALS-FTD Neuron. Oct, 2011 | Pubmed ID: 21944779 Genetics and Genomics of Late-onset Alzheimer's Disease and Its Endophenotypes International Journal of Alzheimer's Disease. 2011 | Pubmed ID: 21660206 Common Variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 Are Associated with Late-onset Alzheimer's Disease Nature Genetics. May, 2011 | Pubmed ID: 21460841 RNA Targets of TDP-43 Identified by UV-CLIP Are Deregulated in ALS Molecular and Cellular Neurosciences. Jul, 2011 | Pubmed ID: 21421050 SORCS1 Alters Amyloid Precursor Protein Processing and Variants May Increase Alzheimer's Disease Risk Annals of Neurology. Jan, 2011 | Pubmed ID: 21280075 Meta-analysis of the Association Between Variants in SORL1 and Alzheimer Disease Archives of Neurology. Jan, 2011 | Pubmed ID: 21220680 Family Reunion--the ZIP/prion Gene Family Progress in Neurobiology. Mar, 2011 | Pubmed ID: 21163327 Identification of Novel Loci for Alzheimer Disease and Replication of CLU, PICALM, and BIN1 in Caribbean Hispanic Individuals Archives of Neurology. Mar, 2011 | Pubmed ID: 21059989 Prevention of Alzheimer's Disease in High Risk Groups: Statin Therapy in Subjects with PSEN1 Mutations or Heterozygosity for Apolipoprotein E Epsilon 4 Alzheimer's Research & Therapy. 2010 | Pubmed ID: 21062519 Intra-familial Clinical Heterogeneity Due to FTLD-U with TDP-43 Proteinopathy Caused by a Novel Deletion in Progranulin Gene (PGRN) Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20930269 Distinct Biochemical Signatures Characterize Peripherin Isoform Expression in Both Traumatic Neuronal Injury and Motor Neuron Disease Journal of Neurochemistry. Aug, 2010 | Pubmed ID: 20533992 Amyotrophic Lateral Sclerosis is a Non-amyloid Disease in Which Extensive Misfolding of SOD1 is Unique to the Familial Form Acta Neuropathologica. Mar, 2010 | Pubmed ID: 20111867 SPATACSIN Mutations Cause Autosomal Recessive Juvenile Amyotrophic Lateral Sclerosis Brain : a Journal of Neurology. Feb, 2010 | Pubmed ID: 20110243 Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease The New England Journal of Medicine. Oct, 2009 | Pubmed ID: 19846850 Lack of Evidence of Monomer/misfolded Superoxide Dismutase-1 in Sporadic Amyotrophic Lateral Sclerosis Annals of Neurology. Jul, 2009 | Pubmed ID: 19670443 Frequent Missense and Insertion/deletion Polymorphisms in the Ovine Shadoo Gene Parallel Species-specific Variation in PrP PloS One. Aug, 2009 | Pubmed ID: 19657386 Further Examination of the Candidate Genes in Chromosome 12p13 Locus for Late-onset Alzheimer Disease Neurogenetics. May, 2008 | Pubmed ID: 18340469 Age-at-onset Linkage Analysis in Caribbean Hispanics with Familial Late-onset Alzheimer's Disease Neurogenetics. Feb, 2008 | Pubmed ID: 17940814 Genetic Studies of GRN and IFT74 in Amyotrophic Lateral Sclerosis Neurobiology of Aging. Aug, 2008 | Pubmed ID: 17383054 The Neuronal Sortilin-related Receptor SORL1 is Genetically Associated with Alzheimer Disease Nature Genetics. Feb, 2007 | Pubmed ID: 17220890 Association Studies Between the Plasmin Genes and Late-onset Alzheimer's Disease Neurobiology of Aging. Jul, 2007 | Pubmed ID: 16828203 Analysis of IFT74 As a Candidate Gene for Chromosome 9p-linked ALS-FTD BMC Neurology. 2006 | Pubmed ID: 17166276 Genetic Complexity of Alzheimer's Disease: Successes and Challenges Journal of Alzheimer's Disease : JAD. 2006 | Pubmed ID: 16914876 TMP21 is a Presenilin Complex Component That Modulates Gamma-secretase but Not Epsilon-secretase Activity Nature. Apr, 2006 | Pubmed ID: 16641999 Association Studies of Cholesterol Metabolism Genes (CH25H, ABCA1 and CH24H) in Alzheimer's Disease Neuroscience Letters. Jan, 2006 | Pubmed ID: 16157450 Wild-type PINK1 Prevents Basal and Induced Neuronal Apoptosis, a Protective Effect Abrogated by Parkinson Disease-related Mutations The Journal of Biological Chemistry. Oct, 2005 | Pubmed ID: 16079129 Analysis of the Glucocerebrosidase Gene in Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Mar, 2005 | Pubmed ID: 15517592 Analysis of the PINK1 Gene in a Large Cohort of Cases with Parkinson Disease Archives of Neurology. Dec, 2004 | Pubmed ID: 15596610 Genetic Association Study of PINK1 Coding Polymorphisms in Parkinson's Disease Neuroscience Letters. Dec, 2004 | Pubmed ID: 15542245 Clinical Findings in a Large Family with a Parkin Ex3delta40 Mutation Archives of Neurology. May, 2004 | Pubmed ID: 15148147 PS1 Alzheimer's Disease Family with Spastic Paraplegia: the Search for a Gene Modifier Neurology. Oct, 2003 | Pubmed ID: 14557582 Brain Levels of CDK5 Activator P25 Are Not Increased in Alzheimer's or Other Neurodegenerative Diseases with Neurofibrillary Tangles Journal of Neurochemistry. Aug, 2003 | Pubmed ID: 12859671 The Solved and Unsolved Mysteries of the Genetics of Early-onset Alzheimer's Disease Neuromolecular Medicine. 2002 | Pubmed ID: 12230301 Genetic Markers in the Diagnosis of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Jun, 2001 | Pubmed ID: 12214050 Screening for PS1 Mutations in a Referral-based Series of AD Cases: 21 Novel Mutations Neurology. Aug, 2001 | Pubmed ID: 11524469 संवैधानिक रोग के आनुवंशिक निर्धारकों का मूल्यांकन करने के लिए लक्षित अगली पीढ़ी के अनुक्रमण और Bioinformatics पाइपलाइन Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetik
संवैधानिक रोग के आनुवंशिक निर्धारकों का मूल्यांकन करने के लिए लक्षित अगली पीढ़ी के अनुक्रमण और Bioinformatics पाइपलाइन Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetik