Ernst Lengyel Department of Obstetrics and Gynecology, Section of Gynecologic Oncology University of Chicago Biography Publications Institution JoVE Articles Ernst Lengyel has not added a biography. If you are Ernst Lengyel and would like to personalize this page please email our Author Liaison for assistance. Publications Corrigendum: Whole-genome Characterization of Chemoresistant Ovarian Cancer Nature. Nov, 2015 | Pubmed ID: 26503049 Rethinking Ovarian Cancer II: Reducing Mortality from High-grade Serous Ovarian Cancer Nature Reviews. Cancer. Nov, 2015 | Pubmed ID: 26493647 Hyperglycemia-induced Metabolic Compensation Inhibits Metformin Sensitivity in Ovarian Cancer Oncotarget. Sep, 2015 | Pubmed ID: 26172303 Glucocorticoid Receptor Activation Inhibits Chemotherapy-induced Cell Death in High-grade Serous Ovarian Carcinoma Gynecologic Oncology. Sep, 2015 | Pubmed ID: 26115975 Whole-genome Characterization of Chemoresistant Ovarian Cancer Nature. May, 2015 | Pubmed ID: 26017449 The Hypoxia-related MicroRNA MiR-199a-3p Displays Tumor Suppressor Functions in Ovarian Carcinoma Oncotarget. May, 2015 | Pubmed ID: 25839163 Patterns and Utility of Routine Surveillance in High Grade Endometrial Cancer Gynecologic Oncology. Jun, 2015 | Pubmed ID: 25838164 Molecular Pathways: Trafficking of Metabolic Resources in the Tumor Microenvironment Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2015 | Pubmed ID: 25691772 Quantitative High Throughput Screening Using a Primary Human Three-dimensional Organotypic Culture Predicts in Vivo Efficacy Nature Communications. 2015 | Pubmed ID: 25653139 Metformin Inhibits Ovarian Cancer Growth and Increases Sensitivity to Paclitaxel in Mouse Models American Journal of Obstetrics and Gynecology. Apr, 2015 | Pubmed ID: 25446664 Old Drug, New Trick: Repurposing Metformin for Gynecologic Cancers? Gynecologic Oncology. Dec, 2014 | Pubmed ID: 25455733 Mesothelial Cells Promote Early Ovarian Cancer Metastasis Through Fibronectin Secretion The Journal of Clinical Investigation. Oct, 2014 | Pubmed ID: 25202979 Statin Therapy is Associated with Improved Survival in Patients with Non-serous-papillary Epithelial Ovarian Cancer: a Retrospective Cohort Analysis PloS One. 2014 | Pubmed ID: 25118694 Three-dimensional Modeling of Ovarian Cancer Advanced Drug Delivery Reviews. Dec, 2014 | Pubmed ID: 25034878 Expression of the Homeobox Gene HOXA9 in Ovarian Cancer Induces Peritoneal Macrophages to Acquire an M2 Tumor-promoting Phenotype The American Journal of Pathology. Jan, 2014 | Pubmed ID: 24332016 Urokinase Plasminogen Activator System-targeted Delivery of Nanobins As a Novel Ovarian Cancer Therapy Molecular Cancer Therapeutics. Dec, 2013 | Pubmed ID: 24061648 Summary of the 2013 American Association for Cancer Research (AACR) Annual Meeting Gynecologic Oncology. Jul, 2013 | Pubmed ID: 23926600 Adipose Tissue and Adipocytes Support Tumorigenesis and Metastasis Biochimica Et Biophysica Acta. Oct, 2013 | Pubmed ID: 23500888 MiR-92a Inhibits Peritoneal Dissemination of Ovarian Cancer Cells by Inhibiting Integrin α5 Expression The American Journal of Pathology. May, 2013 | Pubmed ID: 23499550 Serial Sectioning of the Fallopian Tube Allows for Improved Identification of Primary Fallopian Tube Carcinoma Gynecologic Oncology. Apr, 2013 | Pubmed ID: 23237768 MicroRNAs Reprogram Normal Fibroblasts into Cancer-associated Fibroblasts in Ovarian Cancer Cancer Discovery. Dec, 2012 | Pubmed ID: 23171795 HOXA9 Promotes Ovarian Cancer Growth by Stimulating Cancer-associated Fibroblasts The Journal of Clinical Investigation. Oct, 2012 | Pubmed ID: 22945634 Clinico-pathologic Comparison of Type II Endometrial Cancers Based on Tamoxifen Exposure Gynecologic Oncology. Nov, 2012 | Pubmed ID: 22835717 Relationship of Type II Diabetes and Metformin Use to Ovarian Cancer Progression, Survival, and Chemosensitivity Obstetrics and Gynecology. Jan, 2012 | Pubmed ID: 22183212 The Effects of 17β-estradiol and a Selective Estrogen Receptor Modulator, Bazedoxifene, on Ovarian Carcinogenesis Gynecologic Oncology. Jan, 2012 | Pubmed ID: 21996264 Let-7 Modulates Acquired Resistance of Ovarian Cancer to Taxanes Via IMP-1-mediated Stabilization of Multidrug Resistance 1 International Journal of Cancer. Journal International Du Cancer. Apr, 2012 | Pubmed ID: 21618519 Adipocytes Promote Ovarian Cancer Metastasis and Provide Energy for Rapid Tumor Growth Nature Medicine. 2011 | Pubmed ID: 22037646 The First Line of Intra-abdominal Metastatic Attack: Breaching the Mesothelial Cell Layer Cancer Discovery. Jul, 2011 | Pubmed ID: 22013555 Rethinking Ovarian Cancer: Recommendations for Improving Outcomes Nature Reviews. Cancer. Oct, 2011 | Pubmed ID: 21941283 FOXL2 and SOX9 Distinguish the Lineage of the Sex Cord-stromal Cells in Gonadoblastomas Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society. Sep-Oct, 2011 | Pubmed ID: 21682576 Foretinib (GSK1363089), an Orally Available Multikinase Inhibitor of C-Met and VEGFR-2, Blocks Proliferation, Induces Anoikis, and Impairs Ovarian Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2011 | Pubmed ID: 21551255 Acute Inflammatory Reaction Following Placement of Sodium Hyaluronate-carboxymethylcellulose Barrier in a Young Woman Undergoing Gynecologic Surgery: a Case Report The Journal of Reproductive Medicine. Jan-Feb, 2011 | Pubmed ID: 21366131 A Phase II, Single-arm Study of the Anti-α5β1 Integrin Antibody Volociximab As Monotherapy in Patients with Platinum-resistant Advanced Epithelial Ovarian or Primary Peritoneal Cancer Gynecologic Oncology. May, 2011 | Pubmed ID: 21276608 The Expression of Hepatocyte Growth Factor (HGF) and C-Met in Uterine Serous Carcinoma Gynecologic Oncology. Apr, 2011 | Pubmed ID: 21168200 Targeting the Urokinase Plasminogen Activator Receptor Inhibits Ovarian Cancer Metastasis Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Feb, 2011 | Pubmed ID: 21149615 Ovarian Cancer Development and Metastasis The American Journal of Pathology. Sep, 2010 | Pubmed ID: 20651229 CD95 Promotes Tumour Growth Nature. May, 2010 | Pubmed ID: 20505730 An Orally Available Small-molecule Inhibitor of C-Met, PF-2341066, Reduces Tumor Burden and Metastasis in a Preclinical Model of Ovarian Cancer Metastasis Neoplasia (New York, N.Y.). Jan, 2010 | Pubmed ID: 20072648 The Müllerian HOXA10 Gene Promotes Growth of Ovarian Surface Epithelial Cells by Stimulating Epithelial-stromal Interactions Molecular and Cellular Endocrinology. Apr, 2010 | Pubmed ID: 20036708 The Molecular Signature of Endometriosis-associated Endometrioid Ovarian Cancer Differs Significantly from Endometriosis-independent Endometrioid Ovarian Cancer Fertility and Sterility. Sep, 2010 | Pubmed ID: 19643405 {beta}3-integrin Expression on Tumor Cells Inhibits Tumor Progression, Reduces Metastasis, and is Associated with a Favorable Prognosis in Patients with Ovarian Cancer The American Journal of Pathology. Nov, 2009 | Pubmed ID: 19808644 Organotypic Models of Metastasis: A Three-dimensional Culture Mimicking the Human Peritoneum and Omentum for the Study of the Early Steps of Ovarian Cancer Metastasis Cancer Treatment and Research. 2009 | Pubmed ID: 19763444 Effects of Oral Contraceptives or a Gonadotropin-releasing Hormone Agonist on Ovarian Carcinogenesis in Genetically Engineered Mice Cancer Prevention Research (Philadelphia, Pa.). Sep, 2009 | Pubmed ID: 19737983 Rac1 and Rho Contribute to the Migratory and Invasive Phenotype Associated with Somatic E-cadherin Mutation Human Molecular Genetics. Oct, 2009 | Pubmed ID: 19584084 Up-regulation of Alpha5-integrin by E-cadherin Loss in Hypoxia and Its Key Role in the Migration of Extravillous Trophoblast Cells During Early Implantation Endocrinology. Sep, 2009 | Pubmed ID: 19497979 MMP-2 Functions As an Early Response Protein in Ovarian Cancer Metastasis Cell Cycle (Georgetown, Tex.). Mar, 2009 | Pubmed ID: 19221481 A Novel Multipurpose Monoclonal Antibody for Evaluating Human C-Met Expression in Preclinical and Clinical Settings Applied Immunohistochemistry & Molecular Morphology : AIMM / Official Publication of the Society for Applied Immunohistochemistry. Jan, 2009 | Pubmed ID: 18815565 A Special Key for Unlocking the Door to Targeted Therapies of Breast Cancer TheScientificWorldJournal. 2008 | Pubmed ID: 18836657 Does Equal Treatment Yield Equal Outcomes? The Impact of Race on Survival in Epithelial Ovarian Cancer Gynecologic Oncology. Nov, 2008 | Pubmed ID: 18823649 The MiR-200 Family Determines the Epithelial Phenotype of Cancer Cells by Targeting the E-cadherin Repressors ZEB1 and ZEB2 Genes & Development. Apr, 2008 | Pubmed ID: 18381893 Loss of E-cadherin Promotes Ovarian Cancer Metastasis Via Alpha 5-integrin, Which is a Therapeutic Target Cancer Research. Apr, 2008 | Pubmed ID: 18381440 The Initial Steps of Ovarian Cancer Cell Metastasis Are Mediated by MMP-2 Cleavage of Vitronectin and Fibronectin The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18340378 Thrombin Induces Tumor Invasion Through the Induction and Association of Matrix Metalloproteinase-9 and Beta1-integrin on the Cell Surface The Journal of Biological Chemistry. Feb, 2008 | Pubmed ID: 18048360 Let-7 Prevents Early Cancer Progression by Suppressing Expression of the Embryonic Gene HMGA2 Cell Cycle (Georgetown, Tex.). Nov, 2007 | Pubmed ID: 17957144 Let-7 Expression Defines Two Differentiation Stages of Cancer Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17600087 Use of a Novel 3D Culture Model to Elucidate the Role of Mesothelial Cells, Fibroblasts and Extra-cellular Matrices on Adhesion and Invasion of Ovarian Cancer Cells to the Omentum International Journal of Cancer. Journal International Du Cancer. Oct, 2007 | Pubmed ID: 17546601 Src Induces Urokinase Receptor Gene Expression and Invasion/intravasation Via Activator Protein-1/p-c-Jun in Colorectal Cancer Molecular Cancer Research : MCR. May, 2007 | Pubmed ID: 17510314 Tyrosine Kinase Mutations in Human Cancer Current Molecular Medicine. Feb, 2007 | Pubmed ID: 17311534 C-Met Overexpression is a Prognostic Factor in Ovarian Cancer and an Effective Target for Inhibition of Peritoneal Dissemination and Invasion Cancer Research. Feb, 2007 | Pubmed ID: 17308108 Dosimetric Predictors of Acute Hematologic Toxicity in Cervical Cancer Patients Treated with Concurrent Cisplatin and Intensity-modulated Pelvic Radiotherapy International Journal of Radiation Oncology, Biology, Physics. Dec, 2006 | Pubmed ID: 16757127 Combination Analysis of Activator Protein-1 Family Members, Sp1 and an Activator Protein-2alpha-related Factor Binding to Different Regions of the Urokinase Receptor Gene in Resected Colorectal Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2005 | Pubmed ID: 16361535 C-Met Overexpression in Node-positive Breast Cancer Identifies Patients with Poor Clinical Outcome Independent of Her2/neu International Journal of Cancer. Journal International Du Cancer. Feb, 2005 | Pubmed ID: 15455388 Rac1b, a Tumor Associated, Constitutively Active Rac1 Splice Variant, Promotes Cellular Transformation Oncogene. Dec, 2004 | Pubmed ID: 15516977 Isolation and Characterization of Rac1 Pseudogenes (psi1Rac1-psi4Rac1) in the Human Genome Gene. Oct, 2004 | Pubmed ID: 15474301 Single-agent Pulse Dactinomycin Has Only Modest Activity for Methotrexate-resistant Gestational Trophoblastic Neoplasia Gynecologic Oncology. Jul, 2004 | Pubmed ID: 15262143 Tumor-specific Transcription Factor Binding to an Activator Protein-2/Sp1 Element of the Urokinase-type Plasminogen Activator Receptor Promoter in a First Large Series of Resected Gastrointestinal Cancers Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2003 | Pubmed ID: 12796395 Role of Beta(3)-endonexin in the Regulation of NF-kappaB-dependent Expression of Urokinase-type Plasminogen Activator Receptor Journal of Cell Science. Oct, 2002 | Pubmed ID: 12244126 İnsan periton boşluğuna bir Organotipik Kültür Yumurtalık Kanseri Yaygınlaştırılması Erken Adımlar Modelleme Pamela N. Peters1, Elizabeth M. Schryver1, Ernst Lengyel1, Hilary Kenny1 1Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Medizin
İnsan periton boşluğuna bir Organotipik Kültür Yumurtalık Kanseri Yaygınlaştırılması Erken Adımlar Modelleme Pamela N. Peters1, Elizabeth M. Schryver1, Ernst Lengyel1, Hilary Kenny1 1Department of Obstetrics and Gynecology, Section of Gynecologic Oncology, University of Chicago Medizin