Mario Masellis Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre University of Toronto Biography Publications Institution JoVE Articles Mario Masellis has not added a biography. If you are Mario Masellis and would like to personalize this page please email our Author Liaison for assistance. Publications Downregulation of Exosomal MiR-204-5p and MiR-632 As a Biomarker for FTD: a GENFI Study Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2018 | Pubmed ID: 29434051 Comment: Unraveling DNA Sequence to Identify Cerebral Indicators of Dementia Risk Neurology. Jan, 2018 | Pubmed ID: 29282334 Patterns of Gray Matter Atrophy in Genetic Frontotemporal Dementia: Results from the GENFI Study Neurobiology of Aging. Feb, 2018 | Pubmed ID: 29172163 Progranulin Plasma Levels Predict the Presence of GRN Mutations in Asymptomatic Subjects and Do Not Correlate with Brain Atrophy: Results from the GENFI Study Neurobiology of Aging. Feb, 2018 | Pubmed ID: 29146050 Enhancement of Automated Blood Flow Estimates (ENABLE) from Arterial Spin-labeled MRI Journal of Magnetic Resonance Imaging : JMRI. Mar, 2018 | Pubmed ID: 28681479 Comparison of Arterial Spin Labeling Registration Strategies in the Multi-center GENetic Frontotemporal Dementia Initiative (GENFI) Journal of Magnetic Resonance Imaging : JMRI. Jan, 2018 | Pubmed ID: 28480617 Disinhibition in Alzheimer's Disease Is Associated with Reduced Right Frontal Pole Cortical Thickness Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28984590 Unraveling PINK1 Regulation: Ubiquitination of Its Mature Form and Insights for Parkinson's Disease Movement Disorders : Official Journal of the Movement Disorder Society. Nov, 2017 | Pubmed ID: 28976028 Sex Differences in the Prevalence of Genetic Mutations in FTD and ALS: A Meta-analysis Neurology. Oct, 2017 | Pubmed ID: 28916533 Deconstructing Normal Pressure Hydrocephalus: Ventriculomegaly As Early Sign of Neurodegeneration Annals of Neurology. Oct, 2017 | Pubmed ID: 28892572 Maternal DRD2, SLC6A3, and OXTR Genotypes As Potential Moderators of the Relation Between Maternal History of Care and Maternal Cortisol Secretion in the Context of Mother-infant Separation Biological Psychology. Oct, 2017 | Pubmed ID: 28890000 Dopamine Receptor D2 (DRD2), Dopamine Transporter Solute Carrier Family C6, Member 4 (SLC6A3), and Catechol-O-methyltransferase (COMT) Genes As Moderators of the Relation Between Maternal History of Maltreatment and Infant Emotion Regulation Development and Psychopathology. Aug, 2017 | Pubmed ID: 28803562 Peripheral Lipid Oxidative Stress Markers Are Related to Vascular Risk Factors and Subcortical Small Vessel Disease Neurobiology of Aging. Nov, 2017 | Pubmed ID: 28756941 Motor Phenotype in Neurodegenerative Disorders: Gait and Balance Platform Study Design Protocol for the Ontario Neurodegenerative Research Initiative (ONDRI) Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28671116 Heritability of Hippocampal Subfield Volumes Using a Twin and Non-twin Siblings Design Human Brain Mapping. Sep, 2017 | Pubmed ID: 28561418 White Matter Hyperintensities Are Seen Only Inmutation Carriers in the GENFI Cohort NeuroImage. Clinical. 2017 | Pubmed ID: 28529873 Collagenosis of the Deep Medullary Veins: An Underrecognized Pathologic Correlate of White Matter Hyperintensities and Periventricular Infarction? Journal of Neuropathology and Experimental Neurology. 04, 2017 | Pubmed ID: 28431180 Development of Cognitive Screening Test for the Severely Hearing Impaired: Hearing-impaired MoCA The Laryngoscope. May, 2017 | Pubmed ID: 28409842 The Role of High-field Magnetic Resonance Imaging in Parkinsonian Disorders: Pushing the Boundaries Forward Movement Disorders : Official Journal of the Movement Disorder Society. 04, 2017 | Pubmed ID: 28370449 Neuroimaging and Clinical Features in Adults with a 22q11.2 Deletion at Risk of Parkinson's Disease Brain : a Journal of Neurology. May, 2017 | Pubmed ID: 28369257 Imaging Biomarkers in Parkinson's Disease and Parkinsonian Syndromes: Current and Emerging Concepts Translational Neurodegeneration. 2017 | Pubmed ID: 28360997 Molecular Imaging to Track Parkinson's Disease and Atypical Parkinsonisms: New Imaging Frontiers Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2017 | Pubmed ID: 28150432 Small Vessel Disease is Linked to Disrupted Structural Network Covariance in Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2017 | Pubmed ID: 28137552 The Spatial Coefficient of Variation in Arterial Spin Labeling Cerebral Blood Flow Images Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Sep, 2017 | Pubmed ID: 28058975 Characterizing Familial Corticobasal Syndrome Due to Alzheimer's Disease Pathology and PSEN1 Mutations Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2017 | Pubmed ID: 27743520 The ONDRISeq Panel: Custom-designed Next-generation Sequencing of Genes Related to Neurodegeneration NPJ Genomic Medicine. 2016 | Pubmed ID: 29263818 Lack of Frank Agrammatism in the Nonfluent Agrammatic Variant of Primary Progressive Aphasia Dementia and Geriatric Cognitive Disorders Extra. Sep-Dec, 2016 | Pubmed ID: 27790240 'Under Pressure': is There a Link Between Orthostatic Hypotension and Cognitive Impairment in α-synucleinopathies? Journal of Neurology, Neurosurgery, and Psychiatry. 12, 2016 | Pubmed ID: 27613160 Neurogenic Orthostatic Hypotension and Supine Hypertension in Parkinson's Disease and Related Synucleinopathies: Prioritisation of Treatment Targets The Lancet. Neurology. Aug, 2016 | Pubmed ID: 27478953 Dopamine D2 Receptor Gene Variants and Response to Rasagiline in Early Parkinson's Disease: a Pharmacogenetic Study Brain : a Journal of Neurology. 07, 2016 | Pubmed ID: 27190009 Characterization of Movement Disorder Phenomenology in Genetically Proven, Familial Frontotemporal Lobar Degeneration: A Systematic Review and Meta-Analysis PloS One. 2016 | Pubmed ID: 27100392 MATERNAL SELF-REPORTED DEPRESSIVE SYMPTOMS AND MATERNAL CORTISOL LEVELS INTERACT TO PREDICT INFANT CORTISOL LEVELS Infant Mental Health Journal. Mar-Apr, 2016 | Pubmed ID: 26939829 Orthostatic Hypotension, Cerebral Hypoperfusion, and Visuospatial Deficits in Lewy Body Disorders Parkinsonism & Related Disorders. Jan, 2016 | Pubmed ID: 26639982 Attenuation of Functional Hyperemia to Visual Stimulation in Mild Alzheimer's Disease and Its Sensitivity to Cholinesterase Inhibition Biochimica Et Biophysica Acta. May, 2016 | Pubmed ID: 26521151 Physiological Fluctuations in White Matter Are Increased in Alzheimer's Disease and Correlate with Neuroimaging and Cognitive Biomarkers Neurobiology of Aging. Jan, 2016 | Pubmed ID: 26476600 White Matter Hyperintensity Burden in Elderly Cohort Studies: The Sunnybrook Dementia Study, Alzheimer's Disease Neuroimaging Initiative, and Three-City Study Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Feb, 2016 | Pubmed ID: 26208292 Summary Cortisol Reactivity Indicators: Interrelations and Meaning Neurobiology of Stress. 2015 | Pubmed ID: 26844238 DRD2 and SLC6A3 Moderate Impact of Maternal Depressive Symptoms on Infant Cortisol Psychoneuroendocrinology. Dec, 2015 | Pubmed ID: 26342565 Presymptomatic Cognitive and Neuroanatomical Changes in Genetic Frontotemporal Dementia in the Genetic Frontotemporal Dementia Initiative (GENFI) Study: a Cross-sectional Analysis The Lancet. Neurology. Mar, 2015 | Pubmed ID: 25662776 Differentiating Between Visual Hallucination-free Dementia with Lewy Bodies and Corticobasal Syndrome on the Basis of Neuropsychology and Perfusion Single-photon Emission Computed Tomography Alzheimer's Research & Therapy. 2014 | Pubmed ID: 25484929 Developing Physician Consensus on the Reporting of Patients with Mild Cognitive Impairment and Mild Dementia to Transportation Authorities in a Region with Mandatory Reporting Legislation The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry. Dec, 2014 | Pubmed ID: 24406250 Taking the Kidney Personally: The Quest for Novel Antigens of Idiopathic Membranous Nephropathy Through Proteomic Approaches -? Current Pharmacogenomics and Personalized Medicine. Mar, 2013 | Pubmed ID: 24795785 Fluid Biomarkers for Diagnosing Dementia: Rationale and the Canadian Consensus on Diagnosis and Treatment of Dementia Recommendations for Canadian Physicians Alzheimer's Research & Therapy. Nov, 2013 | Pubmed ID: 24565514 Early-onset Dementias: Diagnostic and Etiological Considerations Alzheimer's Research & Therapy. Jul, 2013 | Pubmed ID: 24565469 A Multicenter Study of Glucocerebrosidase Mutations in Dementia with Lewy Bodies JAMA Neurology. Jun, 2013 | Pubmed ID: 23588557 Public Health Pharmacogenomics and the Design Principles for Global Public Goods - Moving Genomics to Responsible Innovation Current Pharmacogenomics and Personalized Medicine. Mar, 2013 | Pubmed ID: 23531886 Clinical, Imaging, and Pathological Heterogeneity of the Alzheimer's Disease Syndrome Alzheimer's Research & Therapy. Jan, 2013 | Pubmed ID: 23302773 Modulation of the Default-mode Network Between Rest and Task in Alzheimer's Disease Cerebral Cortex (New York, N.Y. : 1991). Jul, 2013 | Pubmed ID: 22693345 Fluorodeoxyglucose Positron Emission Tomography in Semantic Dementia After 6 months of Memantine: an Open-label Pilot Study International Journal of Geriatric Psychiatry. Mar, 2013 | Pubmed ID: 22674572 Investigation of C9orf72 in 4 Neurodegenerative Disorders Archives of Neurology. Sep, 2012 | Pubmed ID: 22964832 End of the Beginning and Public Health Pharmacogenomics: Knowledge in 'Mode 2' and P5 Medicine Current Pharmacogenomics and Personalized Medicine. Jan, 2012 | Pubmed ID: 22545073 Ethical and Policy Considerations in the Application of Pharmacogenomic Testing for Tardive Dyskinesia: Case Study of the Dopamine D3 Receptor Current Pharmacogenomics and Personalized Medicine. Jun, 2011 | Pubmed ID: 22282718 Forward Look: Tenth Anniversary of the Human Genome Sequence and 21 Century Postgenomics Global Health - A Close Up on Africa and Women's Health Current Pharmacogenomics and Personalized Medicine. Sep, 2011 | Pubmed ID: 22279516 Open-label Study of the Short-term Effects of Memantine on FDG-PET in Frontotemporal Dementia Neuropsychiatric Disease and Treatment. 2011 | Pubmed ID: 21792308 Intra-familial Clinical Heterogeneity Due to FTLD-U with TDP-43 Proteinopathy Caused by a Novel Deletion in Progranulin Gene (PGRN) Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20930269 Cholinesterase Inhibitors in Alzheimer's Disease and Lewy Body Spectrum Disorders: the Emerging Pharmacogenetic Story Human Genomics. Dec, 2009 | Pubmed ID: 20038497 Novel 5-HTTLPR Allele Associates with Higher Serotonin Transporter Binding in Putamen: a [(11)C] DASB Positron Emission Tomography Study Biological Psychiatry. Aug, 2007 | Pubmed ID: 17210141 A Birth-season/DRD4 Gene Interaction Predicts Weight Gain and Obesity in Women with Seasonal Affective Disorder: A Seasonal Thrifty Phenotype Hypothesis Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Nov, 2006 | Pubmed ID: 16760922 The Dopamine-4 Receptor Gene Associated with Binge Eating and Weight Gain in Women with Seasonal Affective Disorder: an Evolutionary Perspective Biological Psychiatry. Nov, 2004 | Pubmed ID: 15522250 Polymorphisms in Glutamate Decarboxylase Genes: Analysis in Schizophrenia Psychiatric Genetics. Mar, 2004 | Pubmed ID: 15091314 Quality of Life in OCD: Differential Impact of Obsessions, Compulsions, and Depression Comorbidity Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie. Mar, 2003 | Pubmed ID: 12655903 Pharmacogenomics in Schizophrenia: the Quest for Individualized Therapy Human Molecular Genetics. Oct, 2002 | Pubmed ID: 12351588 Combining Bupropion SR with Venlafaxine, Paroxetine, or Fluoxetine: a Preliminary Report on Pharmacokinetic, Therapeutic, and Sexual Dysfunction Effects The Journal of Clinical Psychiatry. Mar, 2002 | Pubmed ID: 11926715 Psychiatric Pharmacogenetics: Personalizing Psychostimulant Therapy in Attention-deficit/hyperactivity Disorder Behavioural Brain Research. Mar, 2002 | Pubmed ID: 11864722 Absence of Linkage for Schizophrenia on the Short Arm of Chromosome 5 in Multiplex Canadian Families American Journal of Medical Genetics. Sep, 1997 | Pubmed ID: 9342193 Riktade nästa generations sekvensering och bioinformatik Pipeline för att utvärdera genetiska determinanter av konstitutionella sjukdom Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetik
Riktade nästa generations sekvensering och bioinformatik Pipeline för att utvärdera genetiska determinanter av konstitutionella sjukdom Allison A. Dilliott1,2, Sali M.K. Farhan3, Mahdi Ghani4, Christine Sato4, Eric Liang5, Ming Zhang4, Adam D. McIntyre1, Henian Cao1, Lemuel Racacho6,7, John F. Robinson1, Michael J. Strong1,8, Mario Masellis9,10, Dennis E. Bulman6,7, Ekaterina Rogaeva4, Anthony Lang10,11, Carmela Tartaglia4,10, Elizabeth Finger12,13, Lorne Zinman9, John Turnbull14, Morris Freedman10,15, Rick Swartz9, Sandra E. Black9,16, Robert A. Hegele1,2 1Robarts Research Institute, Schulich School of Medicine and Dentistry, Western University, 2Department of Biochemistry, Schulich School of Medicine and Dentistry, Western University, 3Analytic and Translational Genetics Unit, Center for Genomic Medicine, Harvard Medical School, Massachusetts General Hospital, Stanley Centre for Psychiatric Research, Broad Institute of MIT and Harvard, 4Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 5School of Medicine, Faculty of Health Sciences, Queen's University, 6Faculty of Medicine, Department of Biochemistry, Microbiology and Immunology, University of Ottawa, 7CHEO Research Institute, Faculty of Medicine, University of Ottawa, 8Department of Clinical Neurological Sciences, Western University, 9Division of Neurology, Department of Medicine, Sunnybrook Health Sciences Centre, University of Toronto, 10Division of Neurology, Department of Medicine, University of Toronto, 11Morton and Gloria Shulman Movement Disorders Centre, Toronto Western Hospital, 12Department of Clinical Neurological Sciences, Schulich School of Medicine and Dentistry, Western University, 13Parkwood Institute, St. Joseph's Health Care, 14Department of Medicine, Division of Neurology, McMaster University, 15Division of Neurology, Department of Medicine, Baycrest Health Sciences, 16Canadian Partnership for Stroke Recovery Sunnybrook Site, Sunnybrook Health Science Centre, University of Toronto JoVE 57266 Genetik