Philip Van Damme Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute KU Leuven - University of Leuven Biography Publications Institution JoVE Articles Philip Van Damme has not added a biography. If you are Philip Van Damme and would like to personalize this page please email our Author Liaison for assistance. Publications RNF170 Mutation Causes Autosomal Dominant Sensory Ataxia with Variable Pyramidal Involvement European Journal of Neurology. Sep, 2021 | Pubmed ID: 34469621 Tweaking Progranulin Expression: Therapeutic Avenues and Opportunities Frontiers in Molecular Neuroscience. 2021 | Pubmed ID: 34366786 Publisher Correction: Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset Nature Medicine. Jul, 2021 | Pubmed ID: 34079107 Liquid-Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation Biomolecules. 04, 2021 | Pubmed ID: 33917983 Human Motor Units in Microfluidic Devices Are Impaired by FUS Mutations and Improved by HDAC6 Inhibition Stem Cell Reports. Apr, 2021 | Pubmed ID: 33891869 Altered Perivascular Fibroblast Activity Precedes ALS Disease Onset Nature Medicine. 04, 2021 | Pubmed ID: 33859435 -derived Arginine-containing Dipeptide Repeats Associate with Axonal Transport Machinery and Impede Microtubule-based Motility Science Advances. Apr, 2021 | Pubmed ID: 33837088 Prognostic Value of Neurofilament Light Chain in Chronic Inflammatory Demyelinating Polyneuropathy Brain Communications. 2021 | Pubmed ID: 33796853 HDAC6 Inhibition Restores TDP-43 Pathology and Axonal Transport Defects in Human Motor Neurons with TARDBP Mutations The EMBO Journal. Apr, 2021 | Pubmed ID: 33694180 C9orf72 ALS-FTD: Recent Evidence for Dysregulation of the Autophagy-lysosome Pathway at Multiple Levels Autophagy. Feb, 2021 | Pubmed ID: 33632058 STING-Induced Inflammation - A Novel Therapeutic Target in ALS? The New England Journal of Medicine. Feb, 2021 | Pubmed ID: 33626258 AAV9-mediated Gene Delivery of MCT1 to Oligodendrocytes Does Not Provide a Therapeutic Benefit in a Mouse Model of ALS Molecular Therapy. Methods & Clinical Development. Mar, 2021 | Pubmed ID: 33614825 Chitotriosidase As Biomarker for Early Stage Amyotrophic Lateral Sclerosis: a Multicenter Study Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 05, 2021 | Pubmed ID: 33576252 The Effect of SMN Gene Dosage on ALS Risk and Disease Severity Annals of Neurology. 04, 2021 | Pubmed ID: 33389754 PCYT2 Mutations Disrupting Etherlipid Biosynthesis: Phenotypes Converging on the CDP-ethanolamine Pathway Brain : a Journal of Neurology. 03, 2021 | Pubmed ID: 33230519 Brain Metabolic Changes Across King's Stages in Amyotrophic Lateral Sclerosis: a F-2-fluoro-2-deoxy-D-glucose-positron Emission Tomography Study European Journal of Nuclear Medicine and Molecular Imaging. 04, 2021 | Pubmed ID: 33029654 Intracerebroventricular Delivery of Vascular Endothelial Growth Factor in Patients with Amyotrophic Lateral Sclerosis, a Phase I Study Brain Communications. 2020 | Pubmed ID: 33977260 Repeat Expansions Confer Risk for Amyotrophic Lateral Sclerosis and Contribute to TDP-43 Mislocalization Brain Communications. 2020 | Pubmed ID: 32954321 Dipeptide Repeat Protein and TDP-43 Pathology Along the Hypothalamic-pituitary Axis in C9orf72 and Non-C9orf72 ALS and FTLD-TDP Cases Acta Neuropathologica. 11, 2020 | Pubmed ID: 32862270 EphA4 Loss Improves Social Memory Performance and Alters Dendritic Spine Morphology Without Changes in Amyloid Pathology in a Mouse Model of Alzheimer's Disease Alzheimer's Research & Therapy. 12, 2019 | Pubmed ID: 31831046 Circadian Sleep/wake-associated Cells Show Dipeptide Repeat Protein Aggregates in C9orf72-related ALS and FTLD Cases Acta Neuropathologica Communications. 12, 2019 | Pubmed ID: 31791419 C9orf72-generated Poly-GR and Poly-PR Do Not Directly Interfere with Nucleocytoplasmic Transport Scientific Reports. 10, 2019 | Pubmed ID: 31673013 Reducing EphA4 Before Disease Onset Does Not Affect Survival in a Mouse Model of Amyotrophic Lateral Sclerosis Scientific Reports. 10, 2019 | Pubmed ID: 31575928 Reduction of Ephrin-A5 Aggravates Disease Progression in Amyotrophic Lateral Sclerosis Acta Neuropathologica Communications. 07, 2019 | Pubmed ID: 31300041 Restoration of Histone Acetylation Ameliorates Disease and Metabolic Abnormalities in a FUS Mouse Model Acta Neuropathologica Communications. 07, 2019 | Pubmed ID: 31277703 Exome Array Analysis of Rare and Low Frequency Variants in Amyotrophic Lateral Sclerosis Scientific Reports. 04, 2019 | Pubmed ID: 30976013 Microglia Lacking a Peroxisomal β-oxidation Enzyme Chronically Alter Their Inflammatory Profile Without Evoking Neuronal and Behavioral Deficits Journal of Neuroinflammation. Mar, 2019 | Pubmed ID: 30866963 Analytical Performance of a CE-marked Immunoassay to Quantify Phosphorylated Neurofilament Heavy Chains Clinical Chemistry and Laboratory Medicine. 07, 2019 | Pubmed ID: 30710472 Association of NIPA1 Repeat Expansions with Amyotrophic Lateral Sclerosis in a Large International Cohort Neurobiology of Aging. 02, 2019 | Pubmed ID: 30342764 FUS-induced Neurotoxicity in Drosophila is Prevented by Downregulating Nucleocytoplasmic Transport Proteins Human Molecular Genetics. 12, 2018 | Pubmed ID: 30379317 Progranulin Reduces Insoluble TDP-43 Levels, Slows Down Axonal Degeneration and Prolongs Survival in Mutant TDP-43 Mice Molecular Neurodegeneration. 10, 2018 | Pubmed ID: 30326935 Molecular Dissection of FUS Points at Synergistic Effect of Low-Complexity Domains in Toxicity Cell Reports. 07, 2018 | Pubmed ID: 30021151 Astrocyte-derived Jagged-1 Mitigates Deleterious Notch Signaling in Amyotrophic Lateral Sclerosis Neurobiology of Disease. 11, 2018 | Pubmed ID: 30010003 Conditional Deletion of Id2 or Notch1 in Oligodendrocyte Progenitor Cells Does Not Ameliorate Disease Outcome in SOD1 Mice Neurobiology of Aging. Aug, 2018 | Pubmed ID: 29689424 Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 HDAC6 is a Therapeutic Target in Mutant GARS-induced Charcot-Marie-Tooth Disease Brain : a Journal of Neurology. Feb, 2018 | Pubmed ID: 29415205 Elongator Subunit 3 (ELP3) Modifies ALS Through TRNA Modification Human Molecular Genetics. Apr, 2018 | Pubmed ID: 29415125 A Zebrafish Model for C9orf72 ALS Reveals RNA Toxicity As a Pathogenic Mechanism Acta Neuropathologica. Mar, 2018 | Pubmed ID: 29302778 Anterior Interosseous Mononeuropathy Associated with HEV Infection Neurology(R) Neuroimmunology & Neuroinflammation. Mar, 2018 | Pubmed ID: 29296634 Reconsidering the Causality of TIA1 Mutations in ALS Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 02, 2018 | Pubmed ID: 29235362 Inhibition of Histone Deacetylase 6 (HDAC6) Protects Against Vincristine-induced Peripheral Neuropathies and Inhibits Tumor Growth Neurobiology of Disease. Mar, 2018 | Pubmed ID: 29197621 Comparison of Elevated Phosphorylated Neurofilament Heavy Chains in Serum and Cerebrospinal Fluid of Patients with Amyotrophic Lateral Sclerosis Journal of Neurology, Neurosurgery, and Psychiatry. Apr, 2018 | Pubmed ID: 29054919 Defining Y-SNP Variation Among the Flemish Population (Western Europe) by Full Genome Sequencing Forensic Science International. Genetics. 11, 2017 | Pubmed ID: 29089250 Another Piece in the Progranulin Puzzle: Special Binding Between Progranulin and Prosaposin Creates Additional Lysosomal Access: An Editorial Comment for 'The Interaction Between Progranulin and Prosaposin is Mediated by Granulins and the Linker Region Between Saposin B and C' on Page 236 Journal of Neurochemistry. Oct, 2017 | Pubmed ID: 28776681 Prognostic Value of Clinical and Electrodiagnostic Parameters at Time of Diagnosis in Patients with Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Aug, 2017 | Pubmed ID: 28631957 Identification and Characterization of Nanobodies Targeting the EphA4 Receptor The Journal of Biological Chemistry. 07, 2017 | Pubmed ID: 28526745 Screening for Lipoprotein Receptor-related Protein 4-, Agrin-, and Titin-antibodies and Exploring the Autoimmune Spectrum in Myasthenia Gravis Journal of Neurology. Jun, 2017 | Pubmed ID: 28516329 Neurofilament Markers for ALS Correlate with Extent of Upper and Lower Motor Neuron Disease Neurology. Jun, 2017 | Pubmed ID: 28500227 Sporadic Late-onset Nemaline Myopathy: Clinico-pathological Characteristics and Review of 76 Cases Orphanet Journal of Rare Diseases. 05, 2017 | Pubmed ID: 28490364 Progranulin Functions As a Cathepsin D Chaperone to Stimulate Axonal Outgrowth in Vivo Human Molecular Genetics. 08, 2017 | Pubmed ID: 28453791 Randomized Cross-over Trial of Ventilator Modes During Non-invasive Ventilation Titration in Amyotrophic Lateral Sclerosis Respirology (Carlton, Vic.). 08, 2017 | Pubmed ID: 28374969 Phase Separation of C9orf72 Dipeptide Repeats Perturbs Stress Granule Dynamics Molecular Cell. Mar, 2017 | Pubmed ID: 28306503 ATXN2 Trinucleotide Repeat Length Correlates with Risk of ALS Neurobiology of Aging. Mar, 2017 | Pubmed ID: 28017481 Anti-HMGCR Antibodies As a Biomarker for Immune-mediated Necrotizing Myopathies: A History of Statins and Experience from a Large International Multi-center Study Autoimmunity Reviews. Oct, 2016 | Pubmed ID: 27491568 Genome-wide Association Analyses Identify New Risk Variants and the Genetic Architecture of Amyotrophic Lateral Sclerosis Nature Genetics. Sep, 2016 | Pubmed ID: 27455348 Genetic Ablation of IP3 Receptor 2 Increases Cytokines and Decreases Survival of SOD1G93A Mice Human Molecular Genetics. 08, 2016 | Pubmed ID: 27378687 Inside Out: the Role of Nucleocytoplasmic Transport in ALS and FTLD Acta Neuropathologica. Aug, 2016 | Pubmed ID: 27271576 Association of a Locus in the CAMTA1 Gene With Survival in Patients With Sporadic Amyotrophic Lateral Sclerosis JAMA Neurology. Jul, 2016 | Pubmed ID: 27244217 Myasthenia Gravis with Muscle Specific Kinase Antibodies Mimicking Amyotrophic Lateral Sclerosis Neuromuscular Disorders : NMD. 06, 2016 | Pubmed ID: 27133662 Patient-ventilator Asynchrony, Leaks and Sleep in Patients with Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. Jul-Aug, 2016 | Pubmed ID: 27077786 Prospective Validation of 18F-FDG Brain PET Discriminant Analysis Methods in the Diagnosis of Amyotrophic Lateral Sclerosis Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Aug, 2016 | Pubmed ID: 26940764 Drosophila Screen Connects Nuclear Transport Genes to DPR Pathology in C9ALS/FTD Scientific Reports. Feb, 2016 | Pubmed ID: 26869068 Neurological Picture. FDG-PET Findings in Three Cases of Mills' Syndrome Journal of Neurology, Neurosurgery, and Psychiatry. Feb, 2016 | Pubmed ID: 25922081 Prevention of Intestinal Obstruction Reveals Progressive Neurodegeneration in Mutant TDP-43 (A315T) Mice Molecular Neurodegeneration. Jun, 2014 | Pubmed ID: 24938805 Developments in Treatments for Amyotrophic Lateral Sclerosis Via Intracerebroventricular or Intrathecal Delivery Expert Opinion on Investigational Drugs. Jul, 2014 | Pubmed ID: 24816247 Lowering EphA4 Does Not Ameliorate Disease in a Mouse Model for Severe Spinal Muscular Atrophy Frontiers in Neuroscience. | Pubmed ID: 31803009 Differentiation but Not ALS Mutations in FUS Rewires Motor Neuron Metabolism Nature Communications. | Pubmed ID: 31515480 Generazione di unità motorie umane con giunzioni neuromuscolari funzionali in dispositivi microfluidici Katarina Stoklund Dittlau1,2, Emily N. Krasnow1,2, Laura Fumagalli1,2, Tijs Vandoorne1,2, Pieter Baatsen3,4, Axelle Kerstens3,4, Giorgia Giacomazzi5, Benjamin Pavie3,4, Elisabeth Rossaert1,2, Jimmy Beckers1,2, Maurilio Sampaolesi5, Philip Van Damme1,2,6, Ludo Van Den Bosch1,2 1Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven - University of Leuven, 2VIB Center for Brain & Disease Research, Laboratory of Neurobiology, , 3VIB Center for Brain & Disease Research, Research Group Molecular Neurobiology, , 4VIB Bio Imaging Core, KU Leuven - University of Leuven, 5Department of Development and Regeneration, Stem Cell and Developmental Biology, KU Leuven - University of Leuven, 6Department of Neurology, University Hospitals Leuven JoVE 62959 Neurowissenschaften In Vivo Elettrofisiologici misurazione del potenziale di azione muscolare composto da arti anteriori in modelli murini di degenerazione del motoneurone Eveliina Pollari1,2, Robert Prior1,2, Wim Robberecht1,2,3, Philip Van Damme1,2,3, Ludo Van Den Bosch1,2 1Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven, 2Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3Department of Neurology, University Hospitals Leuven JoVE 57741 Neurowissenschaften
Generazione di unità motorie umane con giunzioni neuromuscolari funzionali in dispositivi microfluidici Katarina Stoklund Dittlau1,2, Emily N. Krasnow1,2, Laura Fumagalli1,2, Tijs Vandoorne1,2, Pieter Baatsen3,4, Axelle Kerstens3,4, Giorgia Giacomazzi5, Benjamin Pavie3,4, Elisabeth Rossaert1,2, Jimmy Beckers1,2, Maurilio Sampaolesi5, Philip Van Damme1,2,6, Ludo Van Den Bosch1,2 1Department of Neurosciences, Experimental Neurology, and Leuven Brain Institute, KU Leuven - University of Leuven, 2VIB Center for Brain & Disease Research, Laboratory of Neurobiology, , 3VIB Center for Brain & Disease Research, Research Group Molecular Neurobiology, , 4VIB Bio Imaging Core, KU Leuven - University of Leuven, 5Department of Development and Regeneration, Stem Cell and Developmental Biology, KU Leuven - University of Leuven, 6Department of Neurology, University Hospitals Leuven JoVE 62959 Neurowissenschaften
In Vivo Elettrofisiologici misurazione del potenziale di azione muscolare composto da arti anteriori in modelli murini di degenerazione del motoneurone Eveliina Pollari1,2, Robert Prior1,2, Wim Robberecht1,2,3, Philip Van Damme1,2,3, Ludo Van Den Bosch1,2 1Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven, 2Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, 3Department of Neurology, University Hospitals Leuven JoVE 57741 Neurowissenschaften
