Robert E. Hawkins Manchester Cancer Research Centre Building, Department Cancer Sciences University of Manchester Biography Publications Institution JoVE Articles Robert E. Hawkins has not added a biography. If you are Robert E. Hawkins and would like to personalize this page please email our Author Liaison for assistance. Publications Ex Vivo Expanded Tumour-infiltrating Lymphocytes from Ovarian Cancer Patients Release Anti-tumour Cytokines in Response to Autologous Primary Ovarian Cancer Cells Cancer Immunology, Immunotherapy : CII. Oct, 2018 | Pubmed ID: 30039427 The Clinical Efficacy of First-generation Carcinoembryonic Antigen (CEACAM5)-specific CAR T Cells is Limited by Poor Persistence and Transient Pre-conditioning-dependent Respiratory Toxicity Cancer Immunology, Immunotherapy : CII. Nov, 2017 | Pubmed ID: 28660319 Adjuvant Weekly Girentuximab Following Nephrectomy for High-Risk Renal Cell Carcinoma: The ARISER Randomized Clinical Trial JAMA Oncology. Jul, 2017 | Pubmed ID: 27787547 Randomized Open-Label Phase II Trial of Apitolisib (GDC-0980), a Novel Inhibitor of the PI3K/Mammalian Target of Rapamycin Pathway, Versus Everolimus in Patients With Metastatic Renal Cell Carcinoma Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 05, 2016 | Pubmed ID: 26951309 Integrating Radiation Therapy with Emerging Systemic Therapies: Lessons from a Patient with Cerebral Radionecrosis, Spinal Cord Myelopathy, and Radiation Pneumonitis Practical Radiation Oncology. Mar-Apr, 2016 | Pubmed ID: 26723549 Immunological Response and Overall Survival in a Subset of Advanced Renal Cell Carcinoma Patients from a Randomized Phase 2/3 Study of Naptumomab Estafenatox Plus IFN-α Versus IFN-α Oncotarget. Feb, 2015 | Pubmed ID: 25669986 Immunohistochemical Assessment of NY-ESO-1 Expression in Esophageal Adenocarcinoma Resection Specimens World Journal of Gastroenterology. Apr, 2014 | Pubmed ID: 24744590 Differential Role of Th1 and Th2 Cytokines in Autotoxicity Driven by CD19-specific Second-generation Chimeric Antigen Receptor T Cells in a Mouse Model Journal of Immunology (Baltimore, Md. : 1950). Apr, 2014 | Pubmed ID: 24623129 CAR T Cells: Driving the Road from the Laboratory to the Clinic Immunological Reviews. Jan, 2014 | Pubmed ID: 24329792 Isolation of Tumor Antigen-specific Single-chain Variable Fragments Using a Chimeric Antigen Receptor Bicistronic Retroviral Vector in a Mammalian Screening Protocol Human Gene Therapy Methods. Dec, 2013 | Pubmed ID: 24028672 Potential Limitations of the NSG Humanized Mouse As a Model System to Optimize Engineered Human T Cell Therapy for Cancer Human Gene Therapy Methods. Oct, 2013 | Pubmed ID: 23931270 CAR-T Cells and Solid Tumors: Tuning T Cells to Challenge an Inveterate Foe Trends in Molecular Medicine. Jul, 2012 | Pubmed ID: 22613370 Targeted Immunotherapy of Cancer with CAR T Cells: Achievements and Challenges Cancer Immunology, Immunotherapy : CII. Jul, 2012 | Pubmed ID: 22527245 Tremelimumab (anti-CTLA4) Mediates Immune Responses Mainly by Direct Activation of T Effector Cells Rather Than by Affecting T Regulatory Cells Clinical Immunology (Orlando, Fla.). Jan, 2011 | Pubmed ID: 21056008 Gene Delivery of a Mutant TGFβ3 Reduces Markers of Scar Tissue Formation After Cutaneous Wounding Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2010 | Pubmed ID: 20736928 Functional Expression of Secreted Proteins from a Bicistronic Retroviral Cassette Based on Foot-and-mouth Disease Virus 2A Can Be Position Dependent Human Gene Therapy. Nov, 2010 | Pubmed ID: 20528679 Development of Adoptive Cell Therapy for Cancer: a Clinical Perspective Human Gene Therapy. Jun, 2010 | Pubmed ID: 20408760 Modulation of Lymphocyte Regulation for Cancer Therapy: a Phase II Trial of Tremelimumab in Advanced Gastric and Esophageal Adenocarcinoma Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2010 | Pubmed ID: 20179239 Natural Expression of the CD19 Antigen Impacts the Long-term Engraftment but Not Antitumor Activity of CD19-specific Engineered T Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2010 | Pubmed ID: 20089697 Development of a Flow Cytometric Co-immunoprecipitation Technique for the Study of Multiple Protein-protein Interactions and Its Application to T-cell Receptor Analysis Cytometry. Part A : the Journal of the International Society for Analytical Cytology. Apr, 2010 | Pubmed ID: 20033991 Cytokine Stimulation and the Choice of Promoter Are Critical Factors for the Efficient Transduction of Mouse T Cells with HIV-1 Vectors The Journal of Gene Medicine. Feb, 2010 | Pubmed ID: 20033928 The Second Cellular Therapy of Cancer Symposium, 27-29 March 2009, Milan, Italy Cancer Immunology, Immunotherapy : CII. Jun, 2010 | Pubmed ID: 19669146 T Cell-based Immunotherapy of Metastatic Renal Cell Carcinoma: Modest Success and Future Perspective Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2009 | Pubmed ID: 19843660 Vaccination of Patients with Metastatic Renal Cancer with Modified Vaccinia Ankara Encoding the Tumor Antigen 5T4 (TroVax) Given Alongside Interferon-alpha Journal of Immunotherapy (Hagerstown, Md. : 1997). May, 2009 | Pubmed ID: 19342962 Immune Evasion Mechanisms in Colorectal Cancer Liver Metastasis Patients Vaccinated with TroVax (MVA-5T4) Cancer Immunology, Immunotherapy : CII. Oct, 2009 | Pubmed ID: 19221742 An MVA-based Vaccine Targeting the Oncofetal Antigen 5T4 in Patients Undergoing Surgical Resection of Colorectal Cancer Liver Metastases Journal of Immunotherapy (Hagerstown, Md. : 1997). Nov-Dec, 2008 | Pubmed ID: 18833005 The Combination of Cyclophosphamide and Human T Cells Genetically Engineered to Target CD19 Can Eradicate Established B-cell Lymphoma British Journal of Haematology. Jul, 2008 | Pubmed ID: 18477047 Immunotherapy for Gastrointestinal Cancer: Current Status and Strategies for Improving Efficacy Expert Opinion on Biological Therapy. Apr, 2008 | Pubmed ID: 18352844 CD4+ T-cell Recognition of Human 5T4 Oncofoetal Antigen: Implications for Initial Depletion of CD25+ T Cells Cancer Immunology, Immunotherapy : CII. Jun, 2008 | Pubmed ID: 18004564 Adoptive Transfer of T(reg) Depleted Autologous T Cells in Advanced Renal Cell Carcinoma Cancer Immunology, Immunotherapy : CII. May, 2008 | Pubmed ID: 17899077 Eotaxin-2 and Colorectal Cancer: a Potential Target for Immune Therapy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Oct, 2007 | Pubmed ID: 17908961 Cellular Therapy of Cancer Symposium December 2nd-3rd 2006 Manchester, UK Cancer Immunology, Immunotherapy : CII. Jun, 2007 | Pubmed ID: 17333180 Combination of Vaccination and Chimeric Receptor Expressing T Cells Provides Improved Active Therapy of Tumors Journal of Immunology (Baltimore, Md. : 1950). Oct, 2006 | Pubmed ID: 16982863 Killing of Non-Hodgkin Lymphoma Cells by Autologous CD19 Engineered T Cells British Journal of Haematology. May, 2005 | Pubmed ID: 15842655 The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors: Evaluation of Four Different ScFvs and Antigens Journal of Immunotherapy (Hagerstown, Md. : 1997). May-Jun, 2005 | Pubmed ID: 15838376 Retroviral Transduction with SOX9 Enhances Re-expression of the Chondrocyte Phenotype in Passaged Osteoarthritic Human Articular Chondrocytes Osteoarthritis and Cartilage. Jan, 2005 | Pubmed ID: 15639641 Gene Therapy of Patient-derived T Lymphocytes to Target and Eradicate Colorectal Hepatic Metastases Diseases of the Colon and Rectum. Jun, 2003 | Pubmed ID: 12794582 Cancer Vaccines and Immunotherapy British Medical Bulletin. 2002 | Pubmed ID: 12176857 Primary Polyclonal Human T Lymphocytes Targeted to Carcino-embryonic Antigens and Neural Cell Adhesion Molecule Tumor Antigens by CD3zeta-based Chimeric Immune Receptors Journal of Immunotherapy (Hagerstown, Md. : 1997). Mar-Apr, 2002 | Pubmed ID: 12074044 Un modelo con ratones Syngeneic células B linfoma de evaluación preclínica de las células de T automóvil CD19 Gray Kueberuwa1, Weiming Zheng1, Milena Kalaitsidou1, David E. Gilham1,2, Robert E. Hawkins1 1Manchester Cancer Research Centre Building, Department Cancer Sciences, University of Manchester, 2Celyad JoVE 58492 Krebsforschung
Un modelo con ratones Syngeneic células B linfoma de evaluación preclínica de las células de T automóvil CD19 Gray Kueberuwa1, Weiming Zheng1, Milena Kalaitsidou1, David E. Gilham1,2, Robert E. Hawkins1 1Manchester Cancer Research Centre Building, Department Cancer Sciences, University of Manchester, 2Celyad JoVE 58492 Krebsforschung