Rolf Kaiser Institute of Virology University of Cologne Biography Publications Institution JoVE Articles Rolf Kaiser has not added a biography. If you are Rolf Kaiser and would like to personalize this page please email our Author Liaison for assistance. Publications How Individual Can Personalized Antiretroviral Treatment Be? Deep Salvage in an HIV-1-Infected Patient Intervirology. 2012 | Pubmed ID: 22286888 Efficacy of Antiretroviral Therapy Switch in HIV-Infected Patients: A 10-Year Analysis of the EuResist Cohort Intervirology. 2012 | Pubmed ID: 22286887 Epidemiology of Transmitted Drug Resistance in Chronically HIV-Infected Patients in Germany: The RESINA Study 2001-2009 Intervirology. 2012 | Pubmed ID: 22286886 Risk Factors Associated with Older Age in Treatment-Naive HIV-Positive Patients Intervirology. 2012 | Pubmed ID: 22286885 Predicting Response to Antiretroviral Treatment by Machine Learning: The EuResist Project Intervirology. 2012 | Pubmed ID: 22286881 HIV-GRADE: A Publicly Available, Rules-Based Drug Resistance Interpretation Algorithm Integrating Bioinformatic Knowledge Intervirology. 2012 | Pubmed ID: 22286877 Endogenous or Exogenous Spreading of HIV-1 in Nordrhein-Westfalen, Germany, Investigated by Phylodynamic Analysis of the RESINA Study Cohort Medical Microbiology and Immunology. Jan, 2012 | Pubmed ID: 22262052 APOBEC3G/F As One Possible Driving Force for Co-receptor Switch of the Human Immunodeficiency Virus-1 Medical Microbiology and Immunology. Feb, 2012 | Pubmed ID: 21573951 Mutational Patterns in the Frameshift-regulating Site of HIV-1 Selected by Protease Inhibitors Medical Microbiology and Immunology. Dec, 2011 | Pubmed ID: 22200908 Severe Human Bocavirus Infection, Germany Emerging Infectious Diseases. Dec, 2011 | Pubmed ID: 22172367 Detection of Drug Resistance Mutations at Low Plasma HIV-1 RNA Load in a European Multicentre Cohort Study The Journal of Antimicrobial Chemotherapy. Aug, 2011 | Pubmed ID: 21624929 Genotypic Tropism Testing by Massively Parallel Sequencing: Qualitative and Quantitative Analysis BMC Medical Informatics and Decision Making. 2011 | Pubmed ID: 21569501 The SnoB Study: Frequency of Baseline Raltegravir Resistance Mutations Prevalence in Different Non-B Subtypes Medical Microbiology and Immunology. Nov, 2011 | Pubmed ID: 21475993 HIV Prevalence and Route of Transmission in Turkish Immigrants Living in North-Rhine Westphalia, Germany Medical Microbiology and Immunology. Nov, 2011 | Pubmed ID: 21461764 Treatment of Lung Cancer Patients and Concomitant Use of Drugs Interacting with Cytochrome P450 Isoenzymes Lung Cancer (Amsterdam, Netherlands). Oct, 2011 | Pubmed ID: 21382644 The L76V Mutation in HIV-1 Protease is Potentially Associated with Hypersusceptibility to Protease Inhibitors Atazanavir and Saquinavir: is There a Clinical Advantage? AIDS Research and Therapy. 2011 | Pubmed ID: 21314993 Pharmacokinetics and Metabolism of BIBF 1120 After Oral Dosing to Healthy Male Volunteers Xenobiotica; the Fate of Foreign Compounds in Biological Systems. Apr, 2011 | Pubmed ID: 21204634 Changes in the HIV-1 Mutational Profile Before First-line HAART in the RESINA Cohort Journal of Medical Virology. Feb, 2011 | Pubmed ID: 21181911 Influence of Major HIV-1 Protease Inhibitor Resistance Mutations on CTL Recognition Journal of Acquired Immune Deficiency Syndromes (1999). Feb, 2011 | Pubmed ID: 21107269 Prevalence of Key Resistance Mutations K65R, K103N, and M184V As Minority HIV-1 Variants in Chronically HIV-1 Infected, Treatment-naïve Patients Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Feb, 2011 | Pubmed ID: 21056001 Characterisation of the Epitope for a Herpes Simplex Virus Glycoprotein B-specific Monoclonal Antibody with High Protective Capacity Medical Microbiology and Immunology. May, 2011 | Pubmed ID: 20931340 Prevalence and Characteristics of Hepatitis B and C Virus Infections in Treatment-naïve HIV-infected Patients Medical Microbiology and Immunology. Feb, 2011 | Pubmed ID: 20853118 Antiretroviral Therapy Optimisation Without Genotype Resistance Testing: a Perspective on Treatment History Based Models PloS One. 2010 | Pubmed ID: 21060792 Hepatitis B Virus Reverse Transcriptase Sequence Variant Database for Sequence Analysis and Mutation Discovery Antiviral Research. Dec, 2010 | Pubmed ID: 20875460 Improved Prediction of HIVâ€1 Coreceptor Usage with Sequence Information from the Second Hypervariable Loop of Gp120 The Journal of Infectious Diseases. Nov, 2010 | Pubmed ID: 20874088 Analysis of Immune Selection As a Potential Cause for the Presence of Cleavage Site Mutation 431V in Treatment-naive HIV Type-1 Isolates Antiviral Therapy. 2010 | Pubmed ID: 20834103 Phase I Safety, Pharmacokinetic, and Biomarker Study of BIBF 1120, an Oral Triple Tyrosine Kinase Inhibitor in Patients with Advanced Solid Tumors Molecular Cancer Therapeutics. Oct, 2010 | Pubmed ID: 20688946 Phase I Open-label Study of Continuous Treatment with BIBF 1120, a Triple Angiokinase Inhibitor, and Pemetrexed in Pretreated Non-small Cell Lung Cancer Patients Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2010 | Pubmed ID: 20460487 Evolution of Protease Inhibitor Resistance in the Gag and Pol Genes of HIV Subtype G Isolates The Journal of Antimicrobial Chemotherapy. Jul, 2010 | Pubmed ID: 20430786 Short Communication: Selection of Thymidine Analogue Resistance Mutational Patterns in Children Infected from a Common HIV Type 1 Subtype G Source AIDS Research and Human Retroviruses. Mar, 2010 | Pubmed ID: 20334563 Only Slight Impact of Predicted Replicative Capacity for Therapy Response Prediction PloS One. 2010 | Pubmed ID: 20140263 The Evolution of Protease Mutation 76V is Associated with Protease Mutation 46I and Gag Mutation 431V AIDS (London, England). Mar, 2010 | Pubmed ID: 20139751 Phase I Study of the Angiogenesis Inhibitor BIBF 1120 in Patients with Advanced Solid Tumors Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2010 | Pubmed ID: 20028771 High Prevalence of Bevirimat Resistance Mutations in Protease Inhibitor-resistant HIV Isolates AIDS (London, England). Mar, 2010 | Pubmed ID: 19926962 When and How to Use Maraviroc in HIV-infected Patients AIDS (London, England). Nov, 2009 | Pubmed ID: 19834318 V3 Loop Sequence Space Analysis Suggests Different Evolutionary Patterns of CCR5- and CXCR4-tropic HIV PloS One. 2009 | Pubmed ID: 19816596 Seasonal Influenza Virus Species in Patient Swab Samples Analyzed for the Presence of the Pandemic (H1N1) 2009 Influenza Virus Journal of Clinical Microbiology. Dec, 2009 | Pubmed ID: 19794039 [Resistance Screening] MMW Fortschritte Der Medizin. Apr, 2009 | Pubmed ID: 19769083 Kinetic Binding Analysis of Aptamers Targeting HIV-1 Proteins by a Combination of a Microbalance Array and Mass Spectrometry (MAMS) Journal of Proteome Research. Jul, 2009 | Pubmed ID: 19469583 Evolution of Raltegravir Resistance During Therapy The Journal of Antimicrobial Chemotherapy. Jul, 2009 | Pubmed ID: 19447792 Advantages of Predicted Phenotypes and Statistical Learning Models in Inferring Virological Response to Antiretroviral Therapy from HIV Genotype Antiviral Therapy. 2009 | Pubmed ID: 19430102 Prevalence of Minor Variants of HIV Strains at Reverse Transcriptase Position 103 in Therapy-naïve Patients and Their Impact on the Virological Failure Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. May, 2009 | Pubmed ID: 19375978 Predicting the Response to Combination Antiretroviral Therapy: Retrospective Validation of Geno2pheno-THEO on a Large Clinical Database The Journal of Infectious Diseases. Apr, 2009 | Pubmed ID: 19239365 Prevalence of C-terminal Gag Cleavage Site Mutations in HIV from Therapy-naïve Patients The Journal of Infection. Jan, 2009 | Pubmed ID: 19110315 Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-like Kinase 1 Inhibitor, in Patients with Advanced Solid Tumors Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2008 | Pubmed ID: 18955456 Genotypic Antiretroviral Resistance Testing for Human Immunodeficiency Virus Type 1 Integrase Inhibitors by Use of the TruGene Sequencing System Journal of Clinical Microbiology. Dec, 2008 | Pubmed ID: 18945845 Comparison of Classifier Fusion Methods for Predicting Response to Anti HIV-1 Therapy PloS One. 2008 | Pubmed ID: 18941628 Selecting Anti-HIV Therapies Based on a Variety of Genomic and Clinical Factors Bioinformatics (Oxford, England). Jul, 2008 | Pubmed ID: 18586740 Serotonin Transporter Gene and Response to Lithium Augmentation in Depression Psychiatric Genetics. Apr, 2008 | Pubmed ID: 18349701 Functional Characterization of a -100_-102delAAG Deletion-insertion Polymorphism in the Promoter Region of the HTR3B Gene Pharmacogenetics and Genomics. Mar, 2008 | Pubmed ID: 18300944 Bioinformatics Prediction of HIV Coreceptor Usage Nature Biotechnology. Dec, 2007 | Pubmed ID: 18066037 Predicting HIV Coreceptor Usage on the Basis of Genetic and Clinical Covariates Antiviral Therapy. 2007 | Pubmed ID: 18018768 Fifteen Years of Env C2V3C3 Evolution in Six Individuals Infected Clonally with Human Immunodeficiency Virus Type 1 Journal of Medical Virology. Nov, 2007 | Pubmed ID: 17854039 Selective Pressures of HLA Genotypes and Antiviral Therapy on Human Immunodeficiency Virus Type 1 Sequence Mutation at a Population Level Clinical and Vaccine Immunology : CVI. Oct, 2007 | Pubmed ID: 17715334 Trends of Prevalence of Primary HIV Drug Resistance in Germany The Journal of Antimicrobial Chemotherapy. Oct, 2007 | Pubmed ID: 17715124 Frequent Detection of Cell-associated HIV-1 RNA in Patients with Plasma Viral Load <50 Copies/ml Journal of Medical Virology. Oct, 2007 | Pubmed ID: 17705170 Genetic Polymorphisms in the Amino Acid Transporters LAT1 and LAT2 in Relation to the Pharmacokinetics and Side Effects of Melphalan Pharmacogenetics and Genomics. Jul, 2007 | Pubmed ID: 17558306 Improved Prediction of Response to Antiretroviral Combination Therapy Using the Genetic Barrier to Drug Resistance Antiviral Therapy. 2007 | Pubmed ID: 17503659 A Novel Internally Controlled Real-time Reverse Transcription-PCR Assay for HIV-1 RNA Targeting the Pol Integrase Genomic Region Journal of Virological Methods. Jun, 2007 | Pubmed ID: 17321607 Reactivation of an Occult Hepatitis B Virus Escape Mutant in an Anti-HBs Positive, Anti-HBc Negative Lymphoma Patient Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Jan, 2007 | Pubmed ID: 17134939 Variations of the Melanocortin-1 Receptor and the Glutathione-S Transferase T1 and M1 Genes in Cutaneous Malignant Melanoma Archives of Dermatological Research. Jan, 2007 | Pubmed ID: 17072629 Detection of Bocavirus DNA in Nasopharyngeal Aspirates of a Child with Bronchiolitis The Journal of Infection. Mar, 2007 | Pubmed ID: 16968654 Variations in the Peroxisome Proliferator-activated Receptor-gamma Gene and Melanoma Risk Cancer Letters. Feb, 2007 | Pubmed ID: 16713673 Compensatory Mutations at the HIV Cleavage Sites P7/p1 and P1/p6-gag in Therapy-naive and Therapy-experienced Patients Antiviral Therapy. 2006 | Pubmed ID: 17302250 Severe Pneumonia and Human Bocavirus in Adult Emerging Infectious Diseases. Oct, 2006 | Pubmed ID: 17176591 Functional Domains of the Human Immunodeficiency Virus Type 1 Nef Protein Are Conserved Among Different Clades in Cameroon AIDS Research and Human Retroviruses. Oct, 2006 | Pubmed ID: 17067262 Stable Coreceptor Usage of HIV in Patients with Ongoing Treatment Failure on HAART Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Dec, 2006 | Pubmed ID: 17005445 Primary HIV Drug Resistance and Efficacy of First-line Antiretroviral Therapy Guided by Resistance Testing Journal of Acquired Immune Deficiency Syndromes (1999). Apr, 2006 | Pubmed ID: 16652031 Bioinformatics Approach to Predicting HIV Drug Resistance Expert Review of Molecular Diagnostics. Mar, 2006 | Pubmed ID: 16512780 Basics of the Virology of HIV-1 and Its Replication Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Dec, 2005 | Pubmed ID: 16198625 Evolution of HIV Resistance During Treatment Interruption in Experienced Patients and After Restarting a New Therapy Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Dec, 2005 | Pubmed ID: 16191482 Computational Methods for the Design of Effective Therapies Against Drug Resistant HIV Strains Bioinformatics (Oxford, England). Nov, 2005 | Pubmed ID: 16144807 Learning Multiple Evolutionary Pathways from Cross-sectional Data Journal of Computational Biology : a Journal of Computational Molecular Cell Biology. Jul-Aug, 2005 | Pubmed ID: 16108705 Comparison of GB Virus C, HIV, and HCV Infection Markers in Hemophiliacs Exposed to Non-inactivated or Inactivated Factor Concentrates Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology. Sep, 2005 | Pubmed ID: 16087123 Antiemetic Guidelines: Are They Being Used? The Lancet Oncology. Aug, 2005 | Pubmed ID: 16054573 Estimating HIV Evolutionary Pathways and the Genetic Barrier to Drug Resistance The Journal of Infectious Diseases. Jun, 2005 | Pubmed ID: 15871130 Mtreemix: a Software Package for Learning and Using Mixture Models of Mutagenetic Trees Bioinformatics (Oxford, England). May, 2005 | Pubmed ID: 15657098 Successful Therapy of Hepatitis B with Tenofovir in HIV-infected Patients Failing Previous Adefovir and Lamivudine Treatment AIDS (London, England). Nov, 2004 | Pubmed ID: 15577546 Pharmacogenetics-based New Therapeutic Concepts Drug Metabolism Reviews. Oct, 2004 | Pubmed ID: 15554239 Investigation of the Association Between 5-HT3A Receptor Gene Polymorphisms and Efficiency of Antiemetic Treatment with 5-HT3 Receptor Antagonists Pharmacogenetics. May, 2004 | Pubmed ID: 15115912 Meta-analysis of the Dopamine D3 Receptor Gene (DRD3) Ser9Gly Variant and Schizophrenia Psychiatric Genetics. Mar, 2004 | Pubmed ID: 15091310 Variations in the Genes Encoding the Peroxisome Proliferator-activated Receptors Alpha and Gamma in Psoriasis Archives of Dermatological Research. Jun, 2004 | Pubmed ID: 15083308 Tenofovir Resistance and Resensitization Antimicrobial Agents and Chemotherapy. Nov, 2003 | Pubmed ID: 14576105 Methods for Optimizing Antiviral Combination Therapies Bioinformatics (Oxford, England). 2003 | Pubmed ID: 12855433 Geno2pheno: Estimating Phenotypic Drug Resistance from HIV-1 Genotypes Nucleic Acids Research. Jul, 2003 | Pubmed ID: 12824435 Variations in the 5-hydroxytryptamine Type 3B Receptor Gene As Predictors of the Efficacy of Antiemetic Treatment in Cancer Patients Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2003 | Pubmed ID: 12775740 Frequency of the 17-bp Variable Number of Tandem Repeat Polymorphism in Turkish Schizophrenic Patients Schizophrenia Research. Nov, 2002 | Pubmed ID: 12363397 Risk of Hepatitis C After Immunoadsorption Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America. Jun, 2002 | Pubmed ID: 12083240 Patient-tailored Antiemetic Treatment with 5-hydroxytryptamine Type 3 Receptor Antagonists According to Cytochrome P-450 2D6 Genotypes Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2002 | Pubmed ID: 12065557 Diversity and Complexity of HIV-1 Drug Resistance: a Bioinformatics Approach to Predicting Phenotype from Genotype Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12060770 Efficacy and Safety of Abacavir Plus Efavirenz As a Salvage Regimen in HIV-infected Individuals After 48 Weeks AIDS (London, England). May, 2002 | Pubmed ID: 11953478 Validity of PCR with Emphasis on Variable Number of Tandem Repeat Analysis Clinical Biochemistry. Feb, 2002 | Pubmed ID: 11937078 Simultaneous Determination of Ondansetron and Tropisetron in Human Plasma Using HPLC with UV Detection Biomedical Chromatography : BMC. May, 2002 | Pubmed ID: 11920943 Correlation Between Serotonin Uptake in Human Blood Platelets with the 44-bp Polymorphism and the 17-bp Variable Number of Tandem Repeat of the Serotonin Transporter American Journal of Medical Genetics. Apr, 2002 | Pubmed ID: 11920857 Bir Genotipik Yöntemi'ne Dizi Analizi ile HIV-1 coreceptor Kullanımı (tropizm) Tahmin Saleta Sierra1, Rolf Kaiser1, Nadine Lübke1, Alexander Thielen2, Eugen Schuelter1, Eva Heger1, Martin Däumer3, Stefan Reuter4, Stefan Esser5, Gerd Fätkenheuer6, Herbert Pfister1, Mark Oette7, Thomas Lengauer2 1Institute of Virology, University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology, University of Duesseldorf, 5Department of Dermatology, University of Essen, 6Department of Internal Medicine, University of Cologne, 7Augustinerinnen Hospital JoVE 3264 Immunologie und Infektion
Bir Genotipik Yöntemi'ne Dizi Analizi ile HIV-1 coreceptor Kullanımı (tropizm) Tahmin Saleta Sierra1, Rolf Kaiser1, Nadine Lübke1, Alexander Thielen2, Eugen Schuelter1, Eva Heger1, Martin Däumer3, Stefan Reuter4, Stefan Esser5, Gerd Fätkenheuer6, Herbert Pfister1, Mark Oette7, Thomas Lengauer2 1Institute of Virology, University of Cologne, 2Max Planck Institute for Informatics, 3Institute for Immune genetics, 4Department of Gastroenterology, Hepatology and Infectiology, University of Duesseldorf, 5Department of Dermatology, University of Essen, 6Department of Internal Medicine, University of Cologne, 7Augustinerinnen Hospital JoVE 3264 Immunologie und Infektion