Wei-Li Wu Department of Physiology National Cheng Kung University Biography Publications Institution JoVE Articles Wei-Li Wu Dr. Wei-Li Wu is an assistant professor in the Department of Physiology at the College of Medicine, National Cheng Kung University. Dr. Wu received his M.S. degree in marine biology with Dr. Hin-Kiu Mok and Dr. Chi-Ying Lee as advisors at National Sun Yat-sen University. Dr. Wu's master's study investigated neurotransmission during aggressive behavior using a fighting fish model. Then Dr. Wu received his Ph.D. degree in neuroscience with Dr. Chih-Cheng Chen as advisor at the Academia Sinica. In the Ph.D. training, he profiled the alternations of emotion-related behaviors in a mouse model with sensory deficits. After completing the doctoral degree, Dr. Wu joined the late Prof. Paul Patterson laboratory at Caltech as a postdoctoral scholar in neuroimmunology from 2012 to 2014. In Patterson laboratory, Dr. Wu focused on the gene x environment interactions in a preclinical mouse model of autism spectrum disorder (ASD) and schizophrenia, maternal immune activation. In 2014, Dr. Wu joined Prof. Sarkis Mazmanian laboratory at Caltech to carry on his works from the Patterson lab and to explore a brand-new direction: understanding how gut microbiota mediate mental homeostasis and disease. In Mazmanian laboratory, Dr. Wu interrogated the microbiota-based neural circuits underlying the social behavior using germ-free and antibiotics-treated mice, the mice deprived of the gut microbiota. In 2018, Dr. Wu set up his laboratory at National Cheng Kung University and continuously worked to unravel the neural mechanism by which gut microbiota impact brain circuits and host behaviors. Publications Oral Short-chain Fatty Acids Administration Regulates Innate Anxiety in Adult Microbiome-depleted Mice Neuropharmacology. May, 2022 | Pubmed ID: 35613660 A Gut-derived Metabolite Alters Brain Activity and Anxiety Behaviour in Mice Nature. 02, 2022 | Pubmed ID: 35165440 The Effect of ASIC3 Knockout on Corticostriatal Circuit and Mouse Self-grooming Behavior Frontiers in Cellular Neuroscience. Month, 2019 | Pubmed ID: 30930747 The Protective Role of in a Murine Model of Colitis-Associated Colorectal Cancer MSphere. 11, 2018 | Pubmed ID: 30429227 Cre-dependent Selection Yields AAV Variants for Widespread Gene Transfer to the Adult Brain Nature Biotechnology. Feb, 2016 | Pubmed ID: 26829320 Bilaterality Weighs More Than Unilateral Multifocality in Predicting Prognosis in Papillary Thyroid Cancer Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine. Jan, 2016 | Pubmed ID: 26743781 Explanatory Style Differences in Health Literacy: a Survey Among Young Adults in Taiwan Psychology, Health & Medicine. Mar, 2016 | Pubmed ID: 25532063 [The Volume of Residual Urine Correlates with Bladder Outlet Obstruction and Detrusor Contractility in Patients with Benign Prostatic Hyperplasia] Zhonghua Nan Ke Xue = National Journal of Andrology. Aug, 2015 | Pubmed ID: 26442302 EFFECTS OF MEDICAL DISPUTES ON INTERNET COMMUNICATIONS OF NEGATIVE EMOTIONS AND NEGATIVE ONLINE WORD-OF-MOUTH Psychological Reports. Aug, 2015 | Pubmed ID: 26226491 The Interaction Between Maternal Immune Activation and Alpha 7 Nicotinic Acetylcholine Receptor in Regulating Behaviors in the Offspring Brain, Behavior, and Immunity. May, 2015 | Pubmed ID: 25683697 The Effects of Situated Learning and Health Knowledge Involvement on Health Communications Reproductive Health. Month, 2014 | Pubmed ID: 25542070 A Comparative Study of Transulnar and Transradial Artery Access for Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome Journal of Interventional Cardiology. Oct, 2014 | Pubmed ID: 25250862 Randomized Comparison of Radial Versus Femoral Approach for Patients with STEMI Undergoing Early PCI Following Intravenous Thrombolysis The Journal of Invasive Cardiology. Aug, 2012 | Pubmed ID: 22865313 Safety and Efficacy of Anisodamine on Prevention of Contrast Induced Nephropathy in Patients with Acute Coronary Syndrome Chinese Medical Journal. Mar, 2012 | Pubmed ID: 22613532 Equilibrium Radionuclide Angiography for Evaluating the Effect of Facilitated Percutaneous Coronary Intervention on Ventricular Synchrony in Patients with Acute Myocardial Infarction Circulation Journal : Official Journal of the Japanese Circulation Society. Month, 2012 | Pubmed ID: 22313803 Targeting ASIC3 for Pain, Anxiety, and Insulin Resistance Pharmacology & Therapeutics. May, 2012 | Pubmed ID: 22233754 [Mammary Serine Proteinase Inhibitor Subcellular Expression in Oral Squamous Cell Carcinoma and Its Clinical Significance] Zhonghua Kou Qiang Yi Xue Za Zhi = Zhonghua Kouqiang Yixue Zazhi = Chinese Journal of Stomatology. Aug, 2011 | Pubmed ID: 22169751 Prediction of Contrast-induced Nephropathy in Diabetics Undergoing Elective Percutaneous Coronary Intervention: Role of the Ratio of Contrast Medium Volume to Estimated Glomerular Filtration Rate Chinese Medical Journal. Mar, 2011 | Pubmed ID: 21518598 Synergistic Effect of Bortezomib and Valproic Acid Treatment on the Proliferation and Apoptosis of Acute Myeloid Leukemia and Myelodysplastic Syndrome Cells Annals of Hematology. Aug, 2011 | Pubmed ID: 21340723 [Expressions of CD147, MMP-2 and MMP-9 in Laryngeal Carcinoma and Clinical Significance] Zhonghua Yi Xue Za Zhi. May, 2010 | Pubmed ID: 20646600 Histone H3 Lysine 36 Methyltransferase Hypb/Setd2 is Required for Embryonic Vascular Remodeling Proceedings of the National Academy of Sciences of the United States of America. Feb, 2010 | Pubmed ID: 20133625 [Synergistic Effects of Proteasome Inhibitor and Histone Deacetylase Inhibitor on Apoptosis and Aggresome Formation in T Lymphoma Cells] Zhongguo Shi Yan Xue Ye Xue Za Zhi / Zhongguo Bing Li Sheng Li Xue Hui = Journal of Experimental Hematology / Chinese Association of Pathophysiology. Oct, 2009 | Pubmed ID: 19840453 Equilibrium Radionuclide Angiography for Evaluating the Effect of Percutaneous Coronary Intervention on Ventricular Aneurysm Formation and Systolic Synchrony in Patients with Acute Myocardial Infarction The International Journal of Cardiovascular Imaging. Dec, 2009 | Pubmed ID: 19672689 Asic3(-/-) Female Mice with Hearing Deficit Affects Social Development of Pups PloS One. Month, 2009 | Pubmed ID: 19652708 [The Effect of Different Dispersive Methods on Flexural Strength Nano-ZrO(2) Reinforced Denture Polymethyl Methacrylate] Shanghai Kou Qiang Yi Xue = Shanghai Journal of Stomatology. Jun, 2009 | Pubmed ID: 19649533 Intensive Cholesterol Lowering with Statin Improves the Outcomes of Percutaneous Coronary Intervention in Patients with Acute Coronary Syndrome Chinese Medical Journal. Mar, 2009 | Pubmed ID: 19323930 Voltammetric Behavior of O-Nitrophenol and Damage to DNA International Journal of Molecular Sciences. Mar, 2008 | Pubmed ID: 19325751 [The Influence of Self-improving Based Group Psychotherapy in Defense Mechanisms for the Clients with Social Anxiety Disorder] Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition. Nov, 2008 | Pubmed ID: 19253851 An Amperometric Horseradish Peroxidase Inhibition Biosensor for the Determination of Phenylhydrazine Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry. Jul, 2008 | Pubmed ID: 18614832 Effect of Tirofiban Plus Clopidogrel and Aspirin on Primary Percutaneous Coronary Intervention Via Transradial Approach in Patients with Acute Myocardial Infarction Chinese Medical Journal. Mar, 2008 | Pubmed ID: 18364139 Selective Determination of Dopamine in the Presence of High Concentration of Ascorbic Acid Using Nano-Au Self-assembly Glassy Carbon Electrode Colloids and Surfaces. B, Biointerfaces. Apr, 2008 | Pubmed ID: 18006287 [Influence of Intracoronary Administration of Anisodamine on No-reflow, Ventricular Function and Systolic Synchrony in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention] Zhonghua Xin Xue Guan Bing Za Zhi. Oct, 2007 | Pubmed ID: 18206037 Effect of Intracoronary Administration of Anisodamine on Slow Reflow Phenomenon Following Primary Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction Chinese Medical Journal. Jul, 2007 | Pubmed ID: 17697572 Combined Effects of Histone Deacetylase Inhibitor and Rituximab on Non-Hodgkin's B-lymphoma Cells Apoptosis Experimental Hematology. Dec, 2007 | Pubmed ID: 17681667 Preparation of a Novel Composite Particles and Its Application in the Fluorescent Detection of Proteins Analytical and Bioanalytical Chemistry. Aug, 2006 | Pubmed ID: 16807702 No Correlation Between BRAFV600E Mutation and Clinicopathological Features of Papillary Thyroid Carcinomas in Taiwan Clinical Endocrinology. Oct, 2005 | Pubmed ID: 16181240 [Relationship Between the Adult Attachment Styles of Social Anxiety Disorder (SAD) and Its Cognitive Mode and Behavior Mode] Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition. Mar, 2005 | Pubmed ID: 15807286 [The Reliability and Validity of Adult Attachment Scale (AAS-1996 Revised Edition): a Report on Its Application in China] Sichuan Da Xue Xue Bao. Yi Xue Ban = Journal of Sichuan University. Medical Science Edition. Jul, 2004 | Pubmed ID: 15291121 [Effect of TGF-beta1 on Biological Characteristics of Umbilical Cord Blood Hematopoietic Progenitor Cells During Ex-vivo Expansion] Zhongguo Shi Yan Xue Ye Xue Za Zhi / Zhongguo Bing Li Sheng Li Xue Hui = Journal of Experimental Hematology / Chinese Association of Pathophysiology. Feb, 2004 | Pubmed ID: 14989763 [The Effects of Cardiac Pacing with Multisite Combination on Myocardial Mechanics and Cardiac Work in Dogs] Zhongguo Ying Yong Sheng Li Xue Za Zhi = Zhongguo Yingyong Shenglixue Zazhi = Chinese Journal of Applied Physiology. Nov, 2003 | Pubmed ID: 21166231 [Synergism of As2S2 and STI 571 in Inducing Apoptosis of K562 Cells] Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi. Nov, 2003 | Pubmed ID: 14720443 [Studies on the Dynamics of Biological Characteristics of CD133+ Cells from Human Umbilical Cord Blood During Short-term Culture] Zhongguo Shi Yan Xue Ye Xue Za Zhi / Zhongguo Bing Li Sheng Li Xue Hui = Journal of Experimental Hematology / Chinese Association of Pathophysiology. Dec, 2003 | Pubmed ID: 14706136 [Preliminary Study on the Molecular Mechanism of K562 Cell Apoptosis Induced by As2S2] Zhonghua Zhong Liu Za Zhi [Chinese Journal of Oncology]. May, 2003 | Pubmed ID: 12839680 Apoptotic Effect of As2S2 on K562 Cells and Its Mechanism Acta Pharmacologica Sinica. Nov, 2002 | Pubmed ID: 12421474 [New Retinoid SX-116 Induces Apoptosis of Acute Promyelocytic Leukemia Cell Line NB4] Zhongguo Shi Yan Xue Ye Xue Za Zhi / Zhongguo Bing Li Sheng Li Xue Hui = Journal of Experimental Hematology / Chinese Association of Pathophysiology. Mar, 2001 | Pubmed ID: 12578641 Microbiota Regulate Social Behaviour Via Stress Response Neurons in the Brain Nature. Month, | Pubmed ID: 34194038 自由移动小鼠中肠道来源的微生物代谢物的脑室内递送 Chia-Wei Liou*1,2, Tzu-Hsuan Yao*2, Wei-Li Wu1,2 1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 2Department of Physiology, College of Medicine, National Cheng Kung University JoVE 63972 Neurowissenschaften 母体免疫激活诱导小鼠的病毒性模仿聚妊娠中期阶段(I:C) Ke-Huan Chow*1, Zihao Yan*1,2, Wei-Li Wu1 1Division of Biology and Biological Engineering, California Institute of Technology, 2Harvard Medical School Immunologie und Infektion
自由移动小鼠中肠道来源的微生物代谢物的脑室内递送 Chia-Wei Liou*1,2, Tzu-Hsuan Yao*2, Wei-Li Wu1,2 1Institute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, 2Department of Physiology, College of Medicine, National Cheng Kung University JoVE 63972 Neurowissenschaften
母体免疫激活诱导小鼠的病毒性模仿聚妊娠中期阶段(I:C) Ke-Huan Chow*1, Zihao Yan*1,2, Wei-Li Wu1 1Division of Biology and Biological Engineering, California Institute of Technology, 2Harvard Medical School Immunologie und Infektion