Yale E. Goldman Pennsylvania Muscle Institute, Perelman School of Medicine University of Pennsylvania Biography Publications Institution JoVE Articles Yale E. Goldman has not added a biography. If you are Yale E. Goldman and would like to personalize this page please email our Author Liaison for assistance. Publications Processivity and Velocity for Motors Stepping On Periodic Tracks Biophysical Journal. Apr, 2020 | Pubmed ID: 32367805 Straightening Out the Elasticity of Myosin Cross-Bridges Biophysical Journal. Mar, 2020 | Pubmed ID: 31968230 Nanoaperture Fabrication Via Colloidal Lithography for Single Molecule Fluorescence Analysis PloS One. 2019 | Pubmed ID: 31600217 Single Molecule Mechanics Resolves the Earliest Events in Force Generation by Cardiac Myosin ELife. 09, 2019 | Pubmed ID: 31526481 New Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery ACS Medicinal Chemistry Letters. Dec, 2018 | Pubmed ID: 30613341 Positive Cardiac Inotrope Omecamtiv Mecarbil Activates Muscle Despite Suppressing the Myosin Working Stroke Nature Communications. 09, 2018 | Pubmed ID: 30242219 E. Coli Elongation Factor Tu Bound to a GTP Analogue Displays an Open Conformation Equivalent to the GDP-bound Form Nucleic Acids Research. 09, 2018 | Pubmed ID: 30107565 Structural Dynamics of Translation Elongation Factor Tu During Aa-tRNA Delivery to the Ribosome Nucleic Acids Research. Sep, 2018 | Pubmed ID: 30107527 Translocation Kinetics and Structural Dynamics of Ribosomes Are Modulated by the Conformational Plasticity of Downstream Pseudoknots Nucleic Acids Research. 10, 2018 | Pubmed ID: 30011005 Electro-optic Deflectors Deliver Advantages over Acousto-optical Deflectors in a High Resolution, Ultra-fast Force-clamp Optical Trap Optics Express. Apr, 2018 | Pubmed ID: 29716042 The Antiparallel Dimerization of Myosin X Imparts Bundle Selectivity for Processive Motility Biophysical Journal. 03, 2018 | Pubmed ID: 29590597 TRNA Fluctuations Observed on Stalled Ribosomes Are Suppressed During Ongoing Protein Synthesis Biophysical Journal. Dec, 2017 | Pubmed ID: 29211986 Angular Measurements of the Dynein Ring Reveal a Stepping Mechanism Dependent on a Flexible Stalk Proceedings of the National Academy of Sciences of the United States of America. 06, 2017 | Pubmed ID: 28533393 Deconvolution of Camera Instrument Response Functions Biophysical Journal. Mar, 2017 | Pubmed ID: 28355548 Measuring Molecular Forces Using Calibrated Optical Tweezers in Living Cells Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27844443 Single Molecule Optical Measurements of Orientation and Rotations of Biological Macromolecules Methods and Applications in Fluorescence. 11, 2016 | Pubmed ID: 28192292 MEMLET: An Easy-to-Use Tool for Data Fitting and Model Comparison Using Maximum-Likelihood Estimation Biophysical Journal. Jul, 2016 | Pubmed ID: 27463130 Elongation Factor G Initiates Translocation Through a Power Stroke Proceedings of the National Academy of Sciences of the United States of America. 07, 2016 | Pubmed ID: 27313204 NeutrAvidin Functionalization of CdSe/CdS Quantum Nanorods and Quantification of Biotin Binding Sites Using Biotin-4-Fluorescein Fluorescence Quenching Bioconjugate Chemistry. Mar, 2016 | Pubmed ID: 26722835 EF-Tu Dynamics During Pre-translocation Complex Formation: EF-Tu·GDP Exits the Ribosome Via Two Different Pathways Nucleic Acids Research. Oct, 2015 | Pubmed ID: 26338772 Labeled EF-Tus for Rapid Kinetic Studies of Pretranslocation Complex Formation ACS Chemical Biology. Oct, 2014 | Pubmed ID: 25126896 Reconstituting the Motility of Isolated Intracellular Cargoes Methods in Enzymology. 2014 | Pubmed ID: 24630111 Quantifying Elongation Rhythm During Full-Length Protein Synthesis Journal of the American Chemical Society. Jul, 2013 | Pubmed ID: 23822614 Local Cytoskeletal and Organelle Interactions Impact Molecular-motor- Driven Early Endosomal Trafficking Current Biology : CB. Jul, 2013 | Pubmed ID: 23770188 Tb(3+)-tRNA for LRET Studies of Protein Synthesis Bioconjugate Chemistry. Jul, 2013 | Pubmed ID: 23734598 Dynamics of Translation by Single Ribosomes Through MRNA Secondary Structures Nature Structural & Molecular Biology. May, 2013 | Pubmed ID: 23542154 Tilting and Wobble of Myosin V by High-speed Single-molecule Polarized Fluorescence Microscopy Biophysical Journal. Mar, 2013 | Pubmed ID: 23528086 Orienting Actin Filaments for Directional Motility of Processive Myosin Motors Nano Letters. Jan, 2013 | Pubmed ID: 23240631 Force Measurements on Cargoes in Living Cells Reveal Collective Dynamics of Microtubule Motors Proceedings of the National Academy of Sciences of the United States of America. Nov, 2012 | Pubmed ID: 23091040 Sites of Glucose Transporter-4 Vesicle Fusion with the Plasma Membrane Correlate Spatially with Microtubules PloS One. 2012 | Pubmed ID: 22916292 Myosin IC Generates Power over a Range of Loads Via a New Tension-sensing Mechanism Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22908250 Nanoscale Topography Mediates the Adhesion of F-actin Langmuir : the ACS Journal of Surfaces and Colloids. Aug, 2012 | Pubmed ID: 22839968 Force-dependent Detachment of Kinesin-2 Biases Track Switching at Cytoskeletal Filament Intersections Biophysical Journal. Jul, 2012 | Pubmed ID: 22828331 Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped Following a Mechanical Perturbation PloS One. 2012 | Pubmed ID: 22761792 Exo70 Stimulates the Arp2/3 Complex for Lamellipodia Formation and Directional Cell Migration Current Biology : CB. Aug, 2012 | Pubmed ID: 22748316 Andrew Fielding Huxley (1917-2012) Nature. Jun, 2012 | Pubmed ID: 22739307 FRET-based Identification of MRNAs Undergoing Translation PloS One. 2012 | Pubmed ID: 22693619 Kinetic Schemes for Post-synchronized Single Molecule Dynamics Biophysical Journal. Mar, 2012 | Pubmed ID: 22455931 Dynein Tethers and Stabilizes Dynamic Microtubule Plus Ends Current Biology : CB. Apr, 2012 | Pubmed ID: 22445300 Real-time Assay for Testing Components of Protein Synthesis Nucleic Acids Research. Jul, 2012 | Pubmed ID: 22422844 The Azimuthal Path of Myosin V and Its Dependence on Lever-arm Length The Journal of General Physiology. Feb, 2012 | Pubmed ID: 22291144 Allosteric Vs. Spontaneous Exit-site (E-site) TRNA Dissociation Early in Protein Synthesis Proceedings of the National Academy of Sciences of the United States of America. Oct, 2011 | Pubmed ID: 21969541 The Conserved Protein EF4 (LepA) Modulates the Elongation Cycle of Protein Synthesis Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011 | Pubmed ID: 21930951 Lever-arm Mechanics of Processive Myosins Biophysical Journal. Jul, 2011 | Pubmed ID: 21723809 Single-molecule Fluorescence Measurements of Ribosomal Translocation Dynamics Molecular Cell. May, 2011 | Pubmed ID: 21549313 Changepoint Analysis for Single-molecule Polarized Total Internal Reflection Fluorescence Microscopy Experiments Methods in Enzymology. 2011 | Pubmed ID: 21187234 Enhancement of Single-molecule Fluorescence Signals by Colloidal Silver Nanoparticles in Studies of Protein Translation ACS Nano. Jan, 2011 | Pubmed ID: 21158483 Comparison of Brownian-dynamics-based Estimates of Polymer Tension with Direct Force Measurements Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics. Nov, 2010 | Pubmed ID: 21230516 Electron Tomography of Cryofixed, Isometrically Contracting Insect Flight Muscle Reveals Novel Actin-myosin Interactions PloS One. Sep, 2010 | Pubmed ID: 20844746 Tunable Nanoscale Channels in Diblock Copolymer Films for Biomolecule Organization Langmuir : the ACS Journal of Surfaces and Colloids. Jul, 2010 | Pubmed ID: 20459081 Motor Number Controls Cargo Switching at Actin-microtubule Intersections in Vitro Current Biology : CB. Apr, 2010 | Pubmed ID: 20399098 Myosin VI Lever Arm Rotation: Fixed or Variable? Proceedings of the National Academy of Sciences of the United States of America. Apr, 2010 | Pubmed ID: 20393121 Single-molecule Stepping and Structural Dynamics of Myosin X Nature Structural & Molecular Biology. Apr, 2010 | Pubmed ID: 20364131 Coordination of Molecular Motors: from in Vitro Assays to Intracellular Dynamics Current Opinion in Cell Biology. Feb, 2010 | Pubmed ID: 20102789 Drunk or Sober? Myosin V Walks the (quantum) Dotted Line in Cells Biophysical Journal. Jul, 2009 | Pubmed ID: 19619454 Using Electrical and Optical Tweezers to Facilitate Studies of Molecular Motors Physical Chemistry Chemical Physics : PCCP. Jun, 2009 | Pubmed ID: 19506758 Parallax: High Accuracy Three-dimensional Single Molecule Tracking Using Split Images Nano Letters. Jul, 2009 | Pubmed ID: 19496608 Cross-correlated TIRF/AFM Reveals Asymmetric Distribution of Force-generating Heads Along Self-assembled, "synthetic" Myosin Filaments Biophysical Journal. Mar, 2009 | Pubmed ID: 19254555 Microtubule Plus-end Tracking by CLIP-170 Requires EB1 Proceedings of the National Academy of Sciences of the United States of America. Jan, 2009 | Pubmed ID: 19126680 Twirling of Actin by Myosins II and V Observed Via Polarized TIRF in a Modified Gliding Assay Biophysical Journal. Dec, 2008 | Pubmed ID: 18931255 Effect of Inorganic Phosphate on the Force and Number of Myosin Cross-bridges During the Isometric Contraction of Permeabilized Muscle Fibers from Rabbit Psoas Biophysical Journal. Dec, 2008 | Pubmed ID: 18835889 Kinesin and Dynein-dynactin at Intersecting Microtubules: Motor Density Affects Dynein Function Biophysical Journal. Apr, 2008 | Pubmed ID: 18227130 Differential Regulation of Dynein and Kinesin Motor Proteins by Tau Science (New York, N.Y.). Feb, 2008 | Pubmed ID: 18202255 Myosin VI Walks "wiggly" on Actin with Large and Variable Tilting Molecular Cell. Dec, 2007 | Pubmed ID: 18158894 Calcium Regulation of Calmodulin Binding to and Dissociation from the Myo1c Regulatory Domain Biochemistry. Oct, 2007 | Pubmed ID: 17910470 Single-molecule Structural Dynamics of EF-G--ribosome Interaction During Translocation Biochemistry. Sep, 2007 | Pubmed ID: 17727272 Confinement and Manipulation of Actin Filaments by Electric Fields Biophysical Journal. Oct, 2007 | Pubmed ID: 17693465 Functional Studies of Individual Myosin Molecules Annals of the New York Academy of Sciences. Oct, 2006 | Pubmed ID: 17132771 Processive Bidirectional Motion of Dynein-dynactin Complexes in Vitro Nature Cell Biology. Jun, 2006 | Pubmed ID: 16715075 Defocused Orientation and Position Imaging (DOPI) of Myosin V Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006 | Pubmed ID: 16614073 Adaptability of Myosin V Studied by Simultaneous Detection of Position and Orientation The EMBO Journal. May, 2006 | Pubmed ID: 16601691 Force Generation in Single Conventional Actomyosin Complexes Under High Dynamic Load Biophysical Journal. Feb, 2006 | Pubmed ID: 16326899 Rotational Motions of Macro-molecules by Single-molecule Fluorescence Microscopy Accounts of Chemical Research. Jul, 2005 | Pubmed ID: 16028893 Mechanical Studies of Single Ribosome/mRNA Complexes Biophysical Journal. Sep, 2005 | Pubmed ID: 15951374 Measurement of Single Macromolecule Orientation by Total Internal Reflection Fluorescence Polarization Microscopy Biophysical Journal. Aug, 2005 | Pubmed ID: 15894632 Orientation of the Myosin Light Chain Region by Single Molecule Total Internal Reflection Fluorescence Polarization Microscopy Biophysical Journal. Aug, 2005 | Pubmed ID: 15894631 Cross-bridge Number, Position, and Angle in Target Zones of Cryofixed Isometrically Active Insect Flight Muscle Biophysical Journal. May, 2004 | Pubmed ID: 15111415 Protein Synthesis by Single Ribosomes RNA (New York, N.Y.). Oct, 2003 | Pubmed ID: 13130131 Mechanism of Inhibition of Skeletal Muscle Actomyosin by N-benzyl-p-toluenesulfonamide Biochemistry. May, 2003 | Pubmed ID: 12755615 Three-dimensional Structural Dynamics of Myosin V by Single-molecule Fluorescence Polarization Nature. Mar, 2003 | Pubmed ID: 12660775 Polarized Fluorescence Depletion Reports Orientation Distribution and Rotational Dynamics of Muscle Cross-bridges Biophysical Journal. Aug, 2002 | Pubmed ID: 12124286 Orientation Changes of the Myosin Light Chain Domain During Filament Sliding in Active and Rigor Muscle Journal of Molecular Biology. May, 2002 | Pubmed ID: 12083517 Trading Force for Speed: Why Superfast Crossbridge Kinetics Leads to Superlow Forces Proceedings of the National Academy of Sciences of the United States of America. May, 1999 | Pubmed ID: 10318969 ייצור של מגלי גל במצב אפס למיקרוסקופיה של מולקולה בודדת בריכוז גבוה Kevin Y. Chen1, Ryan M. Jamiolkowski1, Alyssa M. Tate1, Shane A. Fiorenza2, Shawn H. Pfeil2, Yale E. Goldman1 1Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, 2Department of Physics, West Chester University JoVE 61154 Biotechnik
ייצור של מגלי גל במצב אפס למיקרוסקופיה של מולקולה בודדת בריכוז גבוה Kevin Y. Chen1, Ryan M. Jamiolkowski1, Alyssa M. Tate1, Shane A. Fiorenza2, Shawn H. Pfeil2, Yale E. Goldman1 1Pennsylvania Muscle Institute, Perelman School of Medicine, University of Pennsylvania, 2Department of Physics, West Chester University JoVE 61154 Biotechnik