Chronisch obstruktive Lungenerkrankung I: Einführung

COPD encompasses emphysema and chronic bronchitis. Emphysema damages air sacs called alveoli, reducing their elasticity and trapping air in the lungs. Chronic bronchitis involves persistent coughing and mucus secretion due to inflammation of the bronchial tubes and airways. Both conditions lead to progressive lung deterioration and airflow obstruction.

Healthcare providers diagnose COPD by measuring FEV1, the amount of air a patient can force from their lungs in one second, and FVC, the total air they can force out. If the FEV1 to FVC ratio is less than 70%, it confirms COPD diagnosis. Spirometry is the primary test used to measure lung function and assess disease severity.

Cigarette smoking is the most significant environmental risk factor for COPD. Other exposures include secondhand smoke, occupational dust and chemicals, and air pollution from both indoor and outdoor sources. Long-term exposure to these harmful particles and gases damages airways and alveoli, contributing to disease development.

Host factors influencing COPD include genetic abnormalities like alpha-1 antitrypsin deficiency and advancing age. Frequent respiratory infections during childhood and adulthood also increase risk. Lower socioeconomic status is associated with higher exposure to COPD risk factors. These factors combine with environmental exposures to determine individual disease susceptibility.

COPD is classified into four stages based on FEV1 and FVC ratios. Mild COPD has FEV1 ≥ 80% predicted with minimal breathlessness. Moderate COPD ranges from 50-80% predicted with increased breathlessness during exertion. Severe COPD is 30-50% predicted with significant airflow limitations. Very severe COPD is below 30% predicted or below 50% with chronic respiratory failure.

COPD is a progressive respiratory illness that causes airflow obstruction affecting the bronchioles, bronchi, blood vessels, and alveoli. These structures deteriorate due to long-term exposure to harmful particles or gases. The damage results in persistent respiratory symptoms and restricted airflow, progressively worsening breathing challenges.

Smoking cessation is the most vital step in managing COPD. Medications including bronchodilators and inhaled steroids reduce inflammation and open airways. Pulmonary rehabilitation programs combine exercise, education, and support. Oxygen therapy is used for severe COPD with low blood oxygen levels. Surgical options like lung volume reduction surgery may be considered in select cases.