Oleylamine

Oleylamine is a long-chain primary amine derived from oleic acid that serves as a coordinating ligand, solvent, and surface-active reagent in chemical synthesis. Its amine group binds metal ions or nanoparticle surfaces, while its hydrophobic C18 chain promotes dispersion and helps control nucleation, growth, and colloidal stability under heated, oxygen-limited conditions. In bioengineering, oleylamine-assisted synthesis supports the preparation of size- and shape-controlled metallic, semiconductor, and magnetic nanomaterials used in imaging, sensing, drug-delivery research, and biomaterials development. Because the ligand remains on particle surfaces, subsequent purification or ligand exchange is often needed to improve aqueous compatibility and biological performance.

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Research

JoVE Journal - Chemistry

Synthesis, Characterization, and Functionalization of Hybrid Au/CdS and Au/ZnS Core/Shell Nanoparticles

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Cited by 3 •

2016

The synthesis of uniform gold nanoparticles coated with semiconductor shells of CdS or ZnS is performed. The semiconductor coating is conducted by first depositing a silver sulfide shell and exchanging the silver cations for zinc or cadmium cations.

Microwave-driven Synthesis of Iron Oxide Nanoparticles for Fast Detection of Atherosclerosis

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Cited by 2 •

2016

Microwave technology enables extremely fast synthesis of iron oxide nanoparticles for atherosclerosis plaque characterization. The use of an aminobisphosphonate in the external side of the nanoparticle provides a fast accumulation in the atherosclerotic area.

Advanced Compositional Analysis of Nanoparticle-polymer Composites Using Direct Fluorescence Imaging

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Cited by 1 •

2016

Here we present a reliable method to monitor the incorporation of nanoparticles into a polymer host matrix via swell encapsulation. We show that the surface concentration of cadmium selenide quantum dots can be accurately visualized through cross-sectional fluorescence imaging.

Synthesis of Cd-free InP/ZnS Quantum Dots Suitable for Biomedical Applications

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Cited by 12 •

2016

In this protocol, the synthesis of Cd-free InP/ZnS quantum dots (QDs) is detailed. InP-based QDs are gaining popularity due to the toxicity of Cd2+ ions that may be released through nanoparticle degradation. After synthesis, QDs are solubilized in water using an amphiphilic polymer for use in biomedical applications.

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