Ultrasound Triggered Release
Ultrasound Triggered Release - Related Videos
06:02
Multi-timescale Microscopy Methods for the Characterization of Fluorescently-labeled Microbubbles for Ultrasound-Triggered Drug Release
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Cited by 8 •
2021
The presented protocols can be used to characterize the response of fluorescently-labeled microbubbles designed for ultrasound-triggered drug delivery applications, including their activation mechanisms as well as their bioeffects. This paper covers a range of in vitro and in vivo microscopy techniques performed to capture the relevant length and timescales.
08:39
Magnetic and Thermal-sensitive Poly(N-isopropylacrylamide)-based Microgels for Magnetically Triggered Controlled Release
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Cited by 9 •
2017
This manuscript describes the preparation of magnetic and thermal-sensitive microgels via a temperature-induced emulsion without chemical reaction. These sensitive microgels were synthesized by mixing poly(N-isopropylacrylamide) (PNIPAAm), polyethylenimine (PEI) and Fe3O4-NH2 nanoparticles for the potential use in magnetically and thermally triggered drug-release.
05:18
Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
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2023
The deep branch of the radial nerve can easily be compressed at the arcade of Frohse due to its anatomical features. Ultrasound-guided needle release combined with corticosteroid injection is an effective and safe treatment for deep branch radial nerve adhesion.
07:47
Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
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Cited by 17 •
2015
AN MRI-compatible custom-designed laser-based heating apparatus has been developed to provide local heating of subcutaneous tumors in order to activate release of agents from thermosensitive liposomes specifically at the tumor region.
08:41
Ultrasound Velocity Measurement in a Liquid Metal Electrode
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Cited by 14 •
2015
Ultrasound velocimetry is used to study mixing by fluid flow in liquid metal electrodes. The focus of this manuscript is to illustrate the methods used for making precise, spatially-resolved ultrasound measurements while limiting oxidation and controlling and monitoring temperature, applied current, and the heater power being supplied.
FAQs
Ultrasound can influence release through several physical effects rather than a single mechanism. Acoustic pressure may deform a carrier, induce cavitation, produce localized heating, or alter membrane permeability. The dominant effect depends on the material, carrier architecture, and exposure settings. These mechanisms give engineers multiple ways to connect an external acoustic signal with payload release.
Engineered carriers provide the physical environment that holds the drug, gene, or other cargo until an acoustic stimulus is applied. Liposomes, microbubbles, and hydrogels are relevant because ultrasound can interact with these materials through deformation, cavitation, heating, or permeability changes. Carrier selection therefore links the desired payload and release behavior to a material responsive to the chosen exposure.
Frequency, intensity, and exposure duration are the principal adjustable variables identified for controlling release. Changing these settings allows researchers to regulate when and where a payload is released, rather than relying only on passive distribution. This control can help concentrate delivery at a selected site while supporting the broader goal of limiting systemic exposure.
A study begins by placing a drug, gene, or other cargo in an engineered carrier, then selecting an ultrasound exposure and evaluating whether release occurs at the intended location and time. Researchers can vary frequency, intensity, and duration to tune the response. The outcome is considered in relation to localized delivery and the goal of limiting systemic exposure.
Researchers may choose this strategy when treatment requires localized intervention instead of broad distribution throughout the body. The overview identifies targeted drug delivery and applications involving cancer, neurological disorders, and other conditions requiring spatially controlled treatment. External adjustment of the acoustic exposure can support more precise timing and placement of the therapeutic payload.
In bioengineering, ultrasound-controlled release connects engineered materials with externally regulated therapeutic or biological functions. The approach can support tissue engineering as well as minimally invasive therapies by controlling the delivery of drugs, genes, or other cargo near a desired site. Its value lies in combining carrier design with tunable spatial and temporal control.