Lumbosacral Enlargement
Lumbosacral Enlargement - Related Videos
01:22
Enlargement of the Plasma Membrane
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2023
Cell division and enlargement are processes that require precise control. The control ensures that cell division cannot proceed unless the cell has grown to a specific size. A spherical, dividing cell requires an approximately 1.6X increase in its surface area to double its volume. The secretory pathway also has a significant role in cell membrane enlargement. Secretory vesicles that bud off from the Golgi apparatus and later fuse with the plasma membrane during exocytosis are a major source of...
09:11
Using Expansion Microscopy to Physically Enlarge Whole-Mount Drosophila Embryos for Super-Resolution Imaging
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Cited by 5 •
2023
Here, a protocol for the implementation of expansion microscopy in early Drosophila embryos to achieve super-resolution imaging using a conventional laser-scanning confocal microscope is presented.
07:41
Quantification of Levator Ani Hiatus Enlargement by Magnetic Resonance Imaging in Males and Females with Pelvic Organ Prolapse
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Cited by 2 •
2019
Here we present a protocol to standardize the measurement of the levator ani hiatus size by magnetic resonance imaging. The purpose is to extract biomechanical inferences from image analysis by comparing resting and straining values in patients of both sexes with pelvic prolapse, using consistent anatomical bony landmarks.
06:56
Isolation of Macrophages from Mouse Dorsal Root Ganglion Using Mechanical Dissociation
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2025
This video demonstrates an enzyme-free protocol to isolate macrophages from mouse dorsal root ganglion (DRG) using a mechanical dissociation technique. Upon homogenization of the freshly collected DRG tissue, antibodies against the cell-surface receptors on the macrophages are used to label the cells fluorescently, followed by performing flow cytometry to confirm the presence of macrophages in the sample.
07:25
Ovine Lumbar Intervertebral Disc Degeneration Model Utilizing a Lateral Retroperitoneal Drill Bit Injury
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Cited by 18 •
2017
Intervertebral disc degeneration is a significant contributor to back pain and a leading cause of disability worldwide. Numerous animal models of intervertebral disc degeneration exist. We demonstrate an ovine model of intervertebral disc degeneration, utilizing a drill bit, which achieves a consistent disc injury and reproducible level of disc degeneration.
FAQs
Its increased width reflects the concentration of neuronal cell bodies, interneurons, and nerve fibers required for lower-limb control. These elements support the processing of sensory information and the coordination of motor commands carried through lumbar and sacral spinal nerves. The enlargement therefore corresponds to the functional demands of locomotion, posture, and lower-limb reflexes.
The lumbosacral circuits combine commands arriving from the brain with local reflex pathways within the spinal cord. This arrangement allows incoming sensory information to influence lower-limb responses while brain-derived motor instructions are coordinated with spinal activity. Studying this integration helps explain how movement and posture depend on both descending control and local circuit processing.
Neuronal cell bodies provide the cellular basis for processing and transmitting signals, while interneurons connect and organize activity within spinal circuits. Nerve fibers carry sensory input and motor commands through the lumbar and sacral spinal nerves. Their concentration creates an anatomical organization suited to coordinating the complex signaling required by the lower limbs.
Lower-limb reflexes depend on local spinal pathways that can integrate sensory signals and produce coordinated responses. The enlargement provides a concentrated anatomical setting in which these pathways can be examined alongside signals from the brain. Its organization therefore helps connect spinal cord structure with reflex function, rather than treating reflexes as isolated muscle responses.
Researchers can use its organization to relate spinal cord anatomy to locomotion, posture, and lower-limb reflexes. It also provides a reference for examining spinal cord development and comparing vertebrate nervous systems. In neurological research, the same anatomical framework supports interpretation of how injury or disease may affect circuits serving the lower limbs.
Its location and concentrated neural organization identify a spinal region closely associated with lower-limb function. Interpreting changes in this area can therefore help relate anatomical disruption to effects on locomotion, posture, sensory processing, or reflexes. The enlargement serves as a structural reference, while the observed functional consequences indicate which lower-limb pathways may be affected.