Vitamin A Deficiency
Vitamin A Deficiency - Related Videos
12:48
PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
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Cited by 211 •
2013
We describe the production and characterization of nanoparticles and microparticles composed of poly(lactic-co-glycolic acid) using vitamin E-TPGS as an emulsifier. By varying formulation parameters such as the concentration of emulsifier, it is possible to produce nanoparticles with mean diameters ranging from 220 nm to 1.98 µm.
01:30
Vitamins
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2024
Vitamins, derived from the Latin word for life, are essential organic substances required in small quantities for optimal growth and overall well-being. Unlike other organic nutrients, vitamins don't act as sources of energy or building materials but rather facilitate these nutrients' utilization by the body. Vitamins are predominantly coenzymes, assisting enzymes in specific chemical actions, like the oxidation of glucose for energy involving B vitamins. Most vitamins are not produced in our...
04:55
A Simple Mechanical Procedure to Create Limbal Stem Cell Deficiency in Mouse
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Cited by 11 •
2016
The following article provides an easy, reproducible technique to effectively create a sustainable mouse model of limbal stem cell deficiency (LSCD). This animal model is useful in testing and comparing the efficacy of treatments for limbal stem cell diseases.
01:30
Capital Deficiency in Liquidation: I
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2026
During the liquidation of a partnership, a capital deficiency occurs when a partner’s capital account becomes negative after accounting for allocated losses and the payment of liabilities. Resolving such deficiencies is a critical step before the remaining assets can be distributed. However, complications arise when a partner is unable or unwilling to contribute additional funds to eliminate their deficiency.In cases where a partner cannot satisfy their capital deficiency, the loss must be...
28:15
Deficient Pms2, ERCC1, Ku86, CcOI in Field Defects During Progression to Colon Cancer
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Cited by 22 •
2010
Reduced/absent expression of Pms2 and/or ERCC1 in entire crypts is a frequent event within 10 cm on each side of colonic adenocarcinomas, likely the basis of a field defect with high mutability and progression to cancer. Deficiency in Ku86 or CcOI is much less frequent in these field defects.
FAQs
Inadequate vitamin A reduces the supply available to form retinal, the light-sensitive component of visual pigments. These pigments support vision in low-light conditions, so impaired retinal availability can interfere with dark adaptation and produce night blindness. This visual effect provides an important biological clue that vitamin A status is affecting photoreceptor function before more severe eye damage develops.
Vitamin A-derived retinoids help regulate gene expression, meaning they influence which cellular instructions are activated. When vitamin A supply is insufficient, this regulatory role can be disrupted in tissues that depend on retinoid signaling. The consequence extends beyond vision, helping explain why deficiency can affect epithelial maintenance and other biological functions.
Vitamin A supports the maintenance of epithelial tissues, which form protective linings and surfaces in the body. Deficiency can impair this maintenance while also weakening immune defense, creating a biological connection between tissue integrity and susceptibility to infection. Studying both effects shows why vitamin A deficiency is relevant to cellular biology as well as public health.
Night blindness and dry eyes can appear early, reflecting disruption of visual function and eye-surface maintenance. More severe deficiency may progress to xerophthalmia, a serious disorder involving the eye. Tracking this progression helps distinguish early functional changes from advanced tissue damage and emphasizes the value of recognizing symptoms before preventable illness becomes more severe.
Dietary assessment examines whether people may be receiving insufficient vitamin A through their food intake. It can help guide decisions about broader nutritional responses, including supplementation or food fortification. In biology and public health, this approach connects individual dietary patterns with physiological effects and helps target strategies intended to reduce preventable illness.
Children and pregnant individuals are specifically identified as important populations when studying strategies to reduce preventable illness related to vitamin A deficiency. Focusing research and public-health planning on these groups helps connect biological consequences, such as impaired vision or immune defense, with interventions such as dietary assessment, supplementation, and food fortification.