Electrospraying Technique
Electrospraying Technique - Related Videos
04:13
Bioscaffold Fabrication by Electrospraying: A Technique to Generate Microcarrier Scaffolds Derived from Extracellular Matrix of Decellularized Tissue
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2023
This video demonstrates the procedure of extracellular matrix-derived microcarrier fabrication by electrospraying. These microcarriers simulate the native tissue-specific microenvironment and are stable in long-term 3D in vitro cell culture models.
08:38
Electrospray Deposition of Uniform Thickness Ge23Sb7S70 and As40S60 Chalcogenide Glass Films
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Cited by 8 •
2016
A method of uniform thickness solution-derived chalcogenide glass film deposition is demonstrated using computer numerical controlled motion of a single-nozzle electrospray.
10:47
Whole-body Mass Spectrometry Imaging by Infrared Matrix-assisted Laser Desorption Electrospray Ionization (IR-MALDESI)
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Cited by 19 •
2016
A mass spectrometry imaging (MSI) source operated at atmospheric pressure was developed by coupling mid-infrared laser desorption and electrospray post-ionization. Exogenous ice matrix was used as the energy-absorbing matrix to facilitate resonant desorption of tissue-related material. This manuscript provides a step-by-step protocol for performing IR-MALDESI MSI of whole-body neonatal mouse.
12:59
A Study of the Complexation of Mercury(II) with Dicysteinyl Tetrapeptides by Electrospray Ionization Mass Spectrometry
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2016
The characterization of complexes formed in different relative ratios of mercury(II) to dicysteinyl tetrapeptides by electrospray ionization orbitrap mass spectrometry is presented.
08:43
A Quantitative Assessment of The Yeast Lipidome using Electrospray Ionization Mass Spectrometry
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Cited by 39 •
2009
We describe a new quantitative lipidomics method for identifying numerous lipid species in yeast using survey-scan electrospray ionization mass spectrometry (ESI/MS). This method exceeds currently available methods for lipid identification and quantification in the ability to resolve various molecular forms of lipids, sensitivity, and speed.
FAQs
The applied voltage creates an electrostatic force at the liquid meniscus. As this force overcomes surface tension, the meniscus extends into a Taylor cone and emits a jet toward the collector. This sequence is important because it converts the feed liquid into a stream that can fragment into charged droplets, establishing the physical basis for particle fabrication.
Solvent evaporation determines whether droplets remain liquid or leave solid particles during flight to the collector. As solvent leaves, material carried by each droplet becomes concentrated and solidifies. In electrospraying, this transition is central to producing polymeric micro- or nanoparticles rather than simply collecting an unchanged liquid.
Polymeric formulations can carry chemotherapeutic agents, proteins, and other bioactive compounds. Encapsulation places these cargos within micro- or nanoparticles, which can protect them while the material is prepared for delivery. This is particularly useful when a cancer research formulation must combine a therapeutic payload with a carrier designed to support localized administration or controlled release.
An electrospraying setup requires a liquid feed, a needle, a high-voltage source, and a collector. Researchers apply the voltage between needle and collector, form the Taylor cone at the meniscus, and allow the emitted jet to break into droplets. Solvent evaporation then leaves particles on the collector for drug-delivery material or coating fabrication.
Encapsulated cargo can be incorporated into polymeric particles or coatings intended to support localized delivery. Keeping therapeutic material within a fabricated carrier may also protect the cargo and enable controlled release. These features make the technique relevant to cancer research focused on localized treatment strategies.
The technique can accommodate chemotherapeutic agents, proteins, and other bioactive compounds within polymeric micro- or nanoparticles. That flexibility supports research on targeted treatments and combination therapies, where a fabricated carrier may be designed around more than one therapeutic objective. The resulting materials can support cargo protection, localized delivery, and controlled-release behavior.