Rate-programmed Systems

Rate-programmed systems are technologies that control how quickly a substance, energy source, or therapeutic intervention is delivered or changed over time, enabling precise temporal control in clinical settings. They operate by following a defined rate profile, such as a constant, stepped, or gradually increasing and decreasing schedule, while monitoring parameters and adjusting delivery through programmed controls. In clinical practice, these systems support controlled drug infusion, anesthesia administration, hormone delivery, and other time-dependent therapies. By improving dose consistency and coordinating treatment with physiological needs, rate programming can enhance therapeutic outcomes, reduce exposure-related risks, and provide a reproducible framework for clinical research and patient care.

Rate-programmed Systems - Related Videos

Education

JoVE Core - Pharmacokinetics and Pharmacodynamics

Modified-Release Drug Delivery Systems: Rate-Programmed I

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2026

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...

Modified-Release Drug Delivery Systems: Rate-Programmed II

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2026

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...

Research

JoVE Journal - Immunology and Infection
Free Sample

Estimating Virus Production Rates in Aquatic Systems

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Cited by 8 •

2010

The turnover rate of viruses in marine and freshwater systems can be estimated by a reduction and reoccurrence technique. The data allow researchers to infer rates of virus-mediated microbial mortality in aquatic systems.

The Use of Chemostats in Microbial Systems Biology

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Cited by 67 •

2013

Cell growth rate is a regulated process and a primary determinant of cell physiology. Continuous culturing using chemostats enables extrinsic control of cell growth rate by nutrient limitation facilitating the study of molecular networks that control cell growth and how those networks evolve to optimize cell growth.

Programmed Electrical Stimulation in Mice

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Cited by 48 •

2010

Programmed electrical stimulation provides the ability to determine conduction properties of the heart, and the possibility to induce and terminate cardiac arrhythmias using various pacing protocols. Using a transvenous catheter, intracardiac electrogram recordings can be obtained in mice following programmed electrical stimulation protocols to identify arrhythmogenic substrates.

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