Urinary Obstruction
Urinary Obstruction - Related Videos
03:47
Methylene Blue Dye Injection in Mouse Embryonic Urinary Tract: A Method To Assess the Congenital Obstruction in the Urinary Tract
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2025
In this video, we administer methylene blue dye injection into the urinary tract of a perinatal embryonic mouse to assess congenital anomalies related to urinary tract obstruction.
06:05
Assessing Urinary Tract Junction Obstruction Defects by Methylene Blue Dye Injection
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Cited by 1 •
2017
Methylene blue dye injection into the renal pelvis facilitates the assessment of urinary tract junction obstruction defects during mouse embryonic urinary tract development. Here, a protocol for methylene blue dye injection into the renal pelvis is described.
02:19
Unilateral Ureteral Obstruction Murine Model: A Surgical Procedure to Obstruct the Urinary Flow from a Kidney in Mouse Models
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2023
This video demonstrates the procedure to generate a unilateral ureteral obstruction mouse model. The procedure involves cutting one of the ureters of the mouse to obstruct urine flow.
14:05
A Murine Model of Irreversible and Reversible Unilateral Ureteric Obstruction
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Cited by 47 •
2014
The murine model of irreversible unilateral ureteric obstruction (UUO) is presented together with the model of reversible UUO in which the ureteric obstruction is relieved by anastomosis of the severed ureter into the bladder. These models enable the study of renal inflammation and scarring as well as tissue remodeling.
05:05
A Modified Precipitation Method to Isolate Urinary Exosomes
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Cited by 32 •
2015
This manuscript describes a protocol for isolating exosomes from human urine using a modified precipitation technique.
FAQs
Accumulated urine raises pressure upstream from the blockage. That pressure can dilate the ureter and renal collecting system, producing hydronephrosis. As pressure persists, filtration may fall, so kidney function becomes impaired even when the obstruction is not described by symptoms alone. These linked changes explain why identifying and relieving the blockage matters clinically.
Several structural problems can produce the blockage, including stones, strictures, prostate enlargement, and masses. These causes may affect different parts of the urinary tract, so clinicians must determine both the obstruction’s location and its severity rather than relying on a single symptom. Identifying the underlying cause also guides treatment aimed at restoring flow.
Persistent accumulation of urine can maintain elevated upstream pressure, contributing to ureteral dilation, hydronephrosis, and reduced filtration. If flow is not restored, impaired kidney function may progress to permanent renal injury. Prompt drainage or treatment of the underlying cause therefore has a protective purpose: it reduces the consequences of pressure and helps preserve renal function.
Clinicians assess urinary obstruction with symptoms, urine studies, blood tests, and imaging. This combination helps identify the blockage’s location and severity while providing clinical information relevant to infection and impaired kidney function. The assessment establishes the basis for choosing a strategy that restores urine flow or treats the underlying cause.
Available measures include catheter drainage, ureteral stents, and nephrostomy. These approaches create a route for urine to drain when normal passage is blocked. Clinicians can also treat the underlying cause, including a stone, stricture, enlarged prostate, or mass. The overall objective is to restore urine flow and reduce the risk of lasting renal injury.
Successful treatment can restore urine flow and help prevent permanent renal injury. This outcome matters because obstruction can be associated with reduced filtration, hydronephrosis, infection, pain, and impaired kidney function. In clinical practice, relief therefore serves both an immediate purpose, addressing the blocked drainage pathway, and a longer-term purpose, protecting renal function.