The algorithm combines image intensity with spatial context, shape, and anatomical priors to distinguish structures in a 3D representation. Intensity supplies signal differences, while spatial relationships and shape help interpret neighboring or geometrically organized regions. Anatomical priors add expected structural knowledge, which can guide classification when appearance alone is insufficient.
Manual annotation can establish or refine labeled structures, while thresholding, region growing, and deep neural networks provide alternative ways to generate segmentations. The workflow may therefore combine algorithmic labeling with human annotation and refinement. This supports consistent model preparation while reducing labor in medical imaging workflows.
Voxels and surface elements provide different units for labeling a three-dimensional model. Voxel-based classification assigns regions within the volumetric image, whereas surface-based labeling separates parts represented on the model's surfaces. Both approaches can identify anatomy or pathology for separate analysis, but the relevant representation determines how structures are delineated and measured.
A basic workflow identifies the anatomy or pathology of interest, then labels relevant voxels or surface elements using manual annotation, thresholding, region growing, or deep neural networks. Spatial context, shape, intensity, and anatomical priors can guide classification. The resulting labels may be refined before generating measurements or models for downstream medical use.
Segmented models can support quantitative measurements, surgical planning, radiotherapy targeting, disease assessment, and patient-specific visualization. In research and clinical workflows, separating structures such as organs, tumors, blood vessels, and bones allows each region to be analyzed independently. This makes the model useful for examining anatomy, pathology, and treatment-related planning.
Accurate segmentation can improve reproducibility by applying explicit labeled regions to anatomy and pathology. It can also reduce the labor required for clinical and research workflows, particularly when algorithms assist with producing or refining structures. The benefit depends on obtaining accurate labels, because downstream measurements and assessments rely on the separated regions.